Uneingeschränkter Zugang

Circumventing vascular barriers for effective immunotherapy in brain tumors – focus on glioblastoma

Janusz Rak

Janusz Rak

McGill University, The Research Institute of the McGill University Health CentreMontreal, Canada
Orcid-Profil
Suche nach diesem Autor auf
Sciendo|Google Scholar
Rak, Janusz
  
06. Aug. 2025
Circumventing vascular barriers for effective immunotherapy in brain tumors – focus on glioblastoma's Cover Image
Über diesen Artikel
Vorheriger Artikel
Nächster Artikel
Zitieren
COVER HERUNTERLADEN
Artikel-Kategorie: Commentary
Online veröffentlicht: 06. Aug. 2025
Seitenbereich: 95 - 105
Eingereicht: 15. Apr. 2025
Akzeptiert: 20. Mai 2025
DOI: https://doi.org/10.2478/ahem-2025-0012
Schlüsselwörter
© 2025 Janusz Rak, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Targeting the immune-vascular interface in glioblastoma. The combined effect of blood-brain barrier (BBB), blood-tumor barrier (BTB), and endothelial anergy contributes to the exclusion of immune cells (T, NK) from the brain tumor microenvironment. Overcoming this scarcity by intracranial delivery of immune cells, modulating vascular wall (para-endothelial gaps), coupled with tumor debulking (to reduce the size of the target cell population) and targeting immunosuppressive mechanisms may collectively improve outcomes of immunotherapy in glioblastoma and other brain tumors (see text)
Targeting the immune-vascular interface in glioblastoma. The combined effect of blood-brain barrier (BBB), blood-tumor barrier (BTB), and endothelial anergy contributes to the exclusion of immune cells (T, NK) from the brain tumor microenvironment. Overcoming this scarcity by intracranial delivery of immune cells, modulating vascular wall (para-endothelial gaps), coupled with tumor debulking (to reduce the size of the target cell population) and targeting immunosuppressive mechanisms may collectively improve outcomes of immunotherapy in glioblastoma and other brain tumors (see text)
Sprache:
Englisch
Zeitrahmen der Veröffentlichung:
1 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Biologie, Molekularbiologie, Mikrobiologie und Virologie, Medizin, Vorklinische Medizin, Grundlagenmedizin, Immunologie
Zeitschrift RSS Feed