<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Type two diabetes has become a civilization disease in the recent years, and the accompanying obesity, metabolic syndrome and non-alcoholic fatty liver are often the inseparable components of the clinical presentation in patients with diabetes of this type. The treatment of each of these elements is important for optimal metabolic control of the patients, as well as directly affecting their life expectancy. However, The ideal solution would be to take as few drugs as possible, preferably drugs that have a beneficial effect on several coexisting diseases at the same time. In the recent years, there have been more and more reports about the pleiotropic effect of drugs affecting the incretin axis - GLP-1 analogues. The presented paper provides an overview of the latest knowledge on the effect of GLP-1 receptor agonists on weight reduction and reduction of changes in the course of non-alcoholic fatty liver disease.</p>
</abstract>

Type two diabetes has become a civilization disease in the recent years, and the accompanying obesity, metabolic syndrome and non-alcoholic fatty liver are often the inseparable components of the clinical presentation in patients with diabetes of this type. The treatment of each of these elements is important for optimal metabolic control of the patients, as well as directly affecting their life expectancy. However, The ideal solution would be to take as few drugs as possible, preferably drugs that have a beneficial effect on several coexisting diseases at the same time. In the recent years, there have been more and more reports about the pleiotropic effect of drugs affecting the incretin axis - GLP-1 analogues. The presented paper provides an overview of the latest knowledge on the effect of GLP-1 receptor agonists on weight reduction and reduction of changes in the course of non-alcoholic fatty liver disease.

GLP-1 analogues in the treatment of obesity and non-alcoholic fatty liver disease

Medical University of Lodz: Uniwersytet Medyczny w Lodzi

Military Medical Academy Memorial University Teaching Hospital in Łódź

Department of Clinical Pharmacology, 1st Chair of Internal Medicine

Norbert Barlicki Memorial University Teaching Hospital No. 1 in Łódź

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Type two diabetes has become a civilization disease in the recent years, and the accompanying obesity, metabolic syndrome and non-alcoholic fatty liver are...

GLP-1 receptor agonist	Dosing frequency	Registration in monotherapy	Trade name of the product
Exenatide LAR	1 × week	no	Bydureon
Dulaglutide	1 × week	yes	Trulicity
Lixisenatide	1 × day	no	Lyxumia
Liraglutide	1 × day	yes	Victoza
Semaglutide	1 × week	yes	Ozempic

GLP-1 analogues in the treatment of obesity and non-alcoholic fatty liver disease

Article Category: Review

Online veröffentlicht: 28. Feb. 2023

Seitenbereich: 1 - 8

Eingereicht: 05. Apr. 2022

Akzeptiert: 20. Okt. 2022

DOI: https://doi.org/10.2478/ahem-2023-0001

Schlüsselwörter
psoriasis, psoriatic arthritis, lifestyle, diet

© 2022 Kacper Deska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Comparison of the dosage and the possibility of using the individual GLP-1 receptor agonists available on the Polish market as monotherapy, including the trade names of the products. LAR: a form of long-acting release preparation

GLP-1 analogues in the treatment of obesity and non-alcoholic fatty liver disease

Article Category: Review

Online veröffentlicht: 28. Feb. 2023

Seitenbereich: 1 - 8

Eingereicht: 05. Apr. 2022

Akzeptiert: 20. Okt. 2022

DOI: https://doi.org/10.2478/ahem-2023-0001

Schlüsselwörterpsoriasis, psoriatic arthritis, lifestyle, diet

© 2022 Kacper Deska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Comparison of the dosage and the possibility of using the individual GLP-1 receptor agonists available on the Polish market as monotherapy, including the trade names of the products. LAR: a form of long-acting release preparation

Schlüsselwörter
psoriasis, psoriatic arthritis, lifestyle, diet