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Synergistic Antiproliferative Effects of Chondroitin Sulfate and Fucoidan in Tumor-derived Spheroids: Insights From a 3D Cell Culture Approach

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20. Jan. 2025

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COVER HERUNTERLADEN

Anisimova N, Ustyuzhanina N, Bilan M, Donenko F, Usov A, Kiselevskiy M, Nifantiev N. Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice. Mar Drugs. 2017;15:301. PMid:28973980. doi: https://doi.org/10.3390/md15100301. AnisimovaN UstyuzhaninaN BilanM DonenkoF UsovA KiselevskiyM NifantievN Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice Mar Drugs 2017 15 301 28973980 doi: https://doi.org/10.3390/md15100301. Search in Google Scholar

Asimakopoulou AP, Theocharis AD, Tzanakakis GN, Karamanos NK. The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents. In Vivo. 2008;22:385–9. PMid:18610752. . AsimakopoulouAP TheocharisAD TzanakakisGN KaramanosNK The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents In Vivo 2008 22 385 9 18610752 Search in Google Scholar

Bai X, Wang Y, Hu B, Cao Q, Xing M, Song S, Ji A. Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway. Marine Drugs. 2020;18:220. doi: https://doi.org/10.3390/md18040220. BaiX WangY HuB CaoQ XingM SongS JiA Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway Marine Drugs 2020 18 220 doi: https://doi.org/10.3390/md18040220. Search in Google Scholar

Bittkau KS, Dörschmann P, Blümel M, Tasdemir D, Roider J, Klettner A, Alban S. Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines. Mar Drugs. 2019;17:441. PMid:31357497. doi: https://doi.org/10.3390/md17080441. BittkauKS DörschmannP BlümelM TasdemirD RoiderJ KlettnerA AlbanS Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines Mar Drugs 2019 17 441 31357497 doi: https://doi.org/10.3390/md17080441. Search in Google Scholar

Chantree P, Na-Bangchang K, Martviset P. Anticancer Activity of Fucoidan via Apoptosis and Cell Cycle Arrest on Cholangiocarcinoma Cell. Asian Pac J Cancer Prev. 2021;22:209–17. PMid:33507701. doi: https://doi.org/10.31557/APJCP.2021.22.1.209. ChantreeP Na-BangchangK MartvisetP Anticancer Activity of Fucoidan via Apoptosis and Cell Cycle Arrest on Cholangiocarcinoma Cell Asian Pac J Cancer Prev 2021 22 209 17 33507701 doi: https://doi.org/10.31557/APJCP.2021.22.1.209. Search in Google Scholar

Duan Y, Li J, Jing X, Ding X, Yu Y, Zhao Q. Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways. Cancer Manag Res. 2020;12:1713–23. PMid:32210612. doi: https://doi.org/10.2147/CMAR.S243495. DuanY LiJ JingX DingX YuY ZhaoQ Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways Cancer Manag Res 2020 12 1713 23 32210612 doi: https://doi.org/10.2147/CMAR.S243495. Search in Google Scholar

Edmondson R, Broglie JJ, Adcock AF, Yang L. Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay Drug Dev Technol. 2014;12:207–18. PMid:24831787. doi: https://doi.org/10.1089/adt.2014.573. EdmondsonR BroglieJJ AdcockAF YangL Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors Assay Drug Dev Technol 2014 12 207 18 24831787 doi: https://doi.org/10.1089/adt.2014.573. Search in Google Scholar

Hayakawa K, Nagamine T. Effect of Fucoidan on the Biotinidase Kinetics in Human Hepatocellular Carcinoma. Anticancer Research. 2009;29:1211–7. PMid:19414366. . HayakawaK NagamineT Effect of Fucoidan on the Biotinidase Kinetics in Human Hepatocellular Carcinoma Anticancer Research 2009 29 1211 7 19414366 Search in Google Scholar

Hayes AJ, Melrose J. Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs. Front Cell Dev Biol. 2021;9:696640. PMid:34409033. doi: https://doi.org/10.3389/fcell.2021.696640. HayesAJ MelroseJ Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs Front Cell Dev Biol 2021 9 696640 34409033 doi: https://doi.org/10.3389/fcell.2021.696640. Search in Google Scholar

Kapałczyńska M, Kolenda T, Przybyła W, Zajączkowska M, Teresiak A, Filas V, Ibbs M, Bliźniak R, Łuczewski Ł, Lamperska K. 2D and 3D cell cultures – a comparison of different types of cancer cell cultures. Arch Med Sci. 2018;14:910–9. PMid:30002710. doi: https://doi.org/10.5114/aoms.2016.63743. KapałczyńskaM KolendaT PrzybyłaW ZajączkowskaM TeresiakA FilasV IbbsM BliźniakR ŁuczewskiŁ LamperskaK 2D and 3D cell cultures – a comparison of different types of cancer cell cultures Arch Med Sci 2018 14 910 9 30002710 doi: https://doi.org/10.5114/aoms.2016.63743. Search in Google Scholar

Kim BS, Kang H-J, Park J-Y, Lee J. Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2–Smad 1/5/8 signaling in human mesenchymal stem cells. Exp Mol Med. 2015;47:e128–e128. doi: https://doi.org/10.1038/emm.2014.95. KimBS KangH-J ParkJ-Y LeeJ Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2–Smad 1/5/8 signaling in human mesenchymal stem cells Exp Mol Med 2015 47 e128 e128 doi: https://doi.org/10.1038/emm.2014.95. Search in Google Scholar

Kiselevskiy MV, Anisimova NYu, Ustyuzhanina NE, Vinnitskiy DZ, Tokatly AI, Reshetnikova VV, Chikileva IO, Shubina IZh, Kirgizov KI, Nifantiev NE. Perspectives for the Use of Fucoidans in Clinical Oncology. Int J Mol Sci. 2022;23:11821. PMid:36233121. doi: https://doi.org/10.3390/ijms231911821. KiselevskiyMV AnisimovaNYu UstyuzhaninaNE VinnitskiyDZ TokatlyAI ReshetnikovaVV ChikilevaIO ShubinaIZh KirgizovKI NifantievNE Perspectives for the Use of Fucoidans in Clinical Oncology Int J Mol Sci 2022 23 11821 36233121 doi: https://doi.org/10.3390/ijms231911821. Search in Google Scholar

Li H, Fan X, Houghton J. Tumor microenvironment: The role of the tumor stroma in cancer. Journal of Cellular Biochemistry. 2007;101:805–15. doi: https://doi.org/10.1002/jcb.21159. LiH FanX HoughtonJ Tumor microenvironment: The role of the tumor stroma in cancer Journal of Cellular Biochemistry 2007 101 805 15 doi: https://doi.org/10.1002/jcb.21159. Search in Google Scholar

Liu S, Yang J, Peng X, Li J, Zhu C. The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway. Cancer Manag Res. 2020;12:6195–207. PMid:32884336. doi: https://doi.org/10.2147/CMAR.S254784. LiuS YangJ PengX LiJ ZhuC The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway Cancer Manag Res 2020 12 6195 207 32884336 doi: https://doi.org/10.2147/CMAR.S254784. Search in Google Scholar

Mehta G, Hsiao AY, Ingram M, Luker GD, Takayama S. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. J Control Release. 2012;164:192–204. PMid:22613880. doi: https://doi.org/10.1016/j.jconrel.2012.04.045. MehtaG HsiaoAY IngramM LukerGD TakayamaS Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy J Control Release 2012 164 192 204 22613880 doi: https://doi.org/10.1016/j.jconrel.2012.04.045. Search in Google Scholar

Nováková E, Mikušová V, Šupolíková M. Spheroids as 3D Cell Models for Testing of Drugs. European Pharmaceutical Journal. 2023;70:37–43. doi: https://doi.org/10.2478/afpuc-2023-0008. NovákováE MikušováV ŠupolíkováM Spheroids as 3D Cell Models for Testing of Drugs European Pharmaceutical Journal 2023 70 37 43 doi: https://doi.org/10.2478/afpuc-2023-0008. Search in Google Scholar

Saliba J, Manseur C, Groult H, Akil H, Tannoury M, Troutaud D, Maugard T, Feuillard J, Arnaudin I, Jayat-Vignoles C. Anti-Proliferative and Pro-Apoptotic vLMW Fucoidan Formulas Decrease PD-L1 Surface Expression in EBV Latency III and DLBCL Tumoral B-Cells by Decreasing Actin Network. Marine Drugs. 2023;21:132. doi: https://doi.org/10.3390/md21020132. SalibaJ ManseurC GroultH AkilH TannouryM TroutaudD MaugardT FeuillardJ ArnaudinI Jayat-VignolesC Anti-Proliferative and Pro-Apoptotic vLMW Fucoidan Formulas Decrease PD-L1 Surface Expression in EBV Latency III and DLBCL Tumoral B-Cells by Decreasing Actin Network Marine Drugs 2023 21 132 doi: https://doi.org/10.3390/md21020132. Search in Google Scholar

Sanjeewa KKA, Herath KHINM, Yang H-W, Choi CS, Jeon Y-J. Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Mar Drugs. 2021;19:678. PMid:34940677. doi: https://doi.org/10.3390/md19120678. SanjeewaKKA HerathKHINM YangH-W ChoiCS JeonY-J Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review Mar Drugs 2021 19 678 34940677 doi: https://doi.org/10.3390/md19120678. Search in Google Scholar

Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671–5. doi: https://doi.org/10.1038/nmeth.2089. SchneiderCA RasbandWS EliceiriKW NIH Image to ImageJ: 25 years of image analysis Nat Methods 2012 9 671 5 doi: https://doi.org/10.1038/nmeth.2089. Search in Google Scholar

Vinci M, Gowan S, Boxall F, Patterson L, Zimmermann M, Court W, Lomas C, Mendiola M, Hardisson D, Eccles SA. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biology. 2012;10:29. doi: https://doi.org/10.1186/1741-7007-10-29. VinciM GowanS BoxallF PattersonL ZimmermannM CourtW LomasC MendiolaM HardissonD EcclesSA Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation BMC Biology 2012 10 29 doi: https://doi.org/10.1186/1741-7007-10-29. Search in Google Scholar

Zima J, Nováková E, Mikušová V, Šupolíková M. Štúdium liečivých látok na báze glykozaminoglykánov a sulfátovaných heteropolysacharidov s imunomodulačnými vlastnosťami. Bulletin ČSSM. 2022;4:140–51. ZimaJ NovákováE MikušováV ŠupolíkováM Štúdium liečivých látok na báze glykozaminoglykánov a sulfátovaných heteropolysacharidov s imunomodulačnými vlastnosťami Bulletin ČSSM 2022 4 140 51 Search in Google Scholar

Sprache:
Englisch
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2 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Pharmazie, Pharmazie, andere