<abstract xmlns="http://www.w3.org/1999/xhtml">

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in <italic>in vivo</italic> case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against <italic>S. aureus</italic> and <italic>B. subtilis</italic> than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.
</abstract>

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and <italic>in vivo</italic> case report

Department of Pharmaceutical Technology Pharmacognosy and Botany

University of Veterinary Medicine and Pharmacy

Faculty of Science P. J. Šafárik University

Department of Microbiology and Immunology

Clinic of Ruminants of the University of Veterinary Medicine and Pharmacy

Department of Chemistry, Biochemistry and Biophysics

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and  case report

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I)...

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report

Online veröffentlicht: 12. Juni 2023

Seitenbereich: 311 - 323

Akzeptiert: 05. Okt. 2022

DOI: https://doi.org/10.2478/acph-2023-0011

Schlüsselwörter
silver(I) antimicrobial complexes, creams, evaluation, antibacterial activity, pilot case report

© 2023 Simona Sovová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report

Online veröffentlicht: 12. Juni 2023

Seitenbereich: 311 - 323

Akzeptiert: 05. Okt. 2022

DOI: https://doi.org/10.2478/acph-2023-0011

Schlüsselwörtersilver(I) antimicrobial complexes, creams, evaluation, antibacterial activity, pilot case report

© 2023 Simona Sovová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
silver(I) antimicrobial complexes, creams, evaluation, antibacterial activity, pilot case report