<abstract xmlns="http://www.w3.org/1999/xhtml">

<p><italic>Sophora japonica</italic> is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus <italic>Sophorae</italic> extract (FSE) was administered orally for three months at a dose of 200 mg kg<sup>–1</sup> in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. The aglycones of the main active compounds of FSE, daidzin, and genistin, were docked into the alpha and beta estrogen receptors and stable complexes were found. The findings of this study provide an insight into the effects of FSE on bone tissue loss and suggest that it could be further developed as a potential candidate for the prevention of postmenopausal osteoporotic complications.</p>
</abstract>

Sophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. The aglycones of the main active compounds of FSE, daidzin, and genistin, were docked into the alpha and beta estrogen receptors and stable complexes were found. The findings of this study provide an insight into the effects of FSE on bone tissue loss and suggest that it could be further developed as a potential candidate for the prevention of postmenopausal osteoporotic complications.

Beneficial effects of the fructus <italic>Sophorae</italic> extract on experimentally induced osteoporosis in New Zealand white rabbits

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy

Department of Pharmacognosy, Faculty of Pharmacy

Department of Internal Non-infectious Diseases Pathology and Pharmacology, Faculty of Veterinary Medicine

Department of Surgery and Radiology, Faculty of Veterinary Medicine

National Diagnostic and Research Veterinary Institute

Department: National Center of Animal Health

Department of Chemistry, Faculty of Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Beneficial effects of the fructus  extract on experimentally induced osteoporosis in New Zealand white rabbits

Sophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including...

Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits

Article Category: Short communication

Online veröffentlicht: 30. Dez. 2021

Seitenbereich: 289 - 302

Akzeptiert: 07. Apr. 2021

DOI: https://doi.org/10.2478/acph-2022-0012

Schlüsselwörter
osteoporosis, fruits, ovariectomized rabbits, molecular docking, estrogen receptors

© 2022 Lidija Chakuleska., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits

Article Category: Short communication

Online veröffentlicht: 30. Dez. 2021

Seitenbereich: 289 - 302

Akzeptiert: 07. Apr. 2021

DOI: https://doi.org/10.2478/acph-2022-0012

Schlüsselwörterosteoporosis, fruits, ovariectomized rabbits, molecular docking, estrogen receptors

© 2022 Lidija Chakuleska., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
osteoporosis, fruits, ovariectomized rabbits, molecular docking, estrogen receptors