Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels
Online veröffentlicht: 04. Nov. 2020
Seitenbereich: 317 - 324
Akzeptiert: 28. Juni 2020
DOI: https://doi.org/10.2478/acph-2021-0017
Schlüsselwörter
© 2021 Mayra Delgado-Ramírez et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Terfenadine is a second-generation H1-antihistamine that despite potentially can produce severe side effects it has recently gained attention due to its anticancer properties. Lately, the subfamily 2 of inward rectifier potassium channels (Kir2) has been implicated in the progression of some tumoral processes. Hence, we characterized the effects of terfenadine on Kir2.x channels expressed in HEK-293 cells. Terfenadine inhibited Kir2.3 channels with a strikingly greater potency (