<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Piperine (PIP) is an alkaloid present in several species of piper, mainly <italic>Piper nigrum</italic> Linn. and <italic>P. longum</italic>, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different <italic>in vitro</italic> and <italic>in vivo</italic> studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.</p></abstract>

Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. However, its low solubility and absorption make its application challenging. This review also includes advances in the development of nanosystems containing PIP, including liposomes, micelles, metal nanoparticles, nanofibers, polymeric nanoparticles, and solid-lipid nanoparticles. Finally, we discuss different in vitro and in vivo studies to evaluate the biological activity of this drug, as well as some methods for the synthesis of nanosystems and their physical characteristics.

Piperine: Chemical, biological and nanotechnological applications

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Piperine: Chemical, biological and nanotechnological applications"}

Piperine (PIP) is an alkaloid present in several species of piper, mainly Piper nigrum Linn. and P. longum, among other species. The present article provides a...

Piperine: Chemical, biological and nanotechnological applications

Online veröffentlicht: 04. Nov. 2020

Seitenbereich: 185 - 213

Akzeptiert: 31. Mai 2020

DOI: https://doi.org/10.2478/acph-2021-0015

Schlüsselwörter
absorption, metabolism, pharmacological activity, nanosystems

© 2021 Christian Rafael Quijia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Piperine: Chemical, biological and nanotechnological applications

Online veröffentlicht: 04. Nov. 2020

Seitenbereich: 185 - 213

Akzeptiert: 31. Mai 2020

DOI: https://doi.org/10.2478/acph-2021-0015

Schlüsselwörterabsorption, metabolism, pharmacological activity, nanosystems

© 2021 Christian Rafael Quijia et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
absorption, metabolism, pharmacological activity, nanosystems