<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L<sup>-1</sup> HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.</p></abstract>

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.

In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets

Shenyang Pharmaceutical University Shenyang 110016, Liaoning Province China

The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China

Acta Pharmaceutica

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro...

In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets

Online veröffentlicht: 31. Dez. 2013

Seitenbereich: 545 - 551

DOI: https://doi.org/10.2478/acph-2013-0035

Schlüsselwörter
salbutamol sulfate, press-coated tablet, PEG 6000-Eudragit S100 blends, dissolution, gamma scintigraphy

This content is open access.

In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets

Online veröffentlicht: 31. Dez. 2013

Seitenbereich: 545 - 551

DOI: https://doi.org/10.2478/acph-2013-0035

Schlüsselwörtersalbutamol sulfate, press-coated tablet, PEG 6000-Eudragit S100 blends, dissolution, gamma scintigraphy

This content is open access.

Schlüsselwörter
salbutamol sulfate, press-coated tablet, PEG 6000-Eudragit S100 blends, dissolution, gamma scintigraphy