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New molecular markers involved in immune system homeostasis and hemopoietic organ development are differentially regulated during oocytes in vitro maturation

Lisa Moncrieff
Lisa Moncrieff
, 
Ievgeniia Kocherova
Ievgeniia Kocherova
, 
Artur Bryja
Artur Bryja
, 
Wiesława Kranc
Wiesława Kranc
, 
Joanna Perek
Joanna Perek
, 
Piotr Celichowski
Piotr Celichowski
, 
Magdalena Kulus
Magdalena Kulus
, 
Bartosz Kempisty
Bartosz Kempisty
, 
Paul Mozdziak
Paul Mozdziak
 und 
Michal Jeseta
Michal Jeseta
   | 29. Apr. 2020
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Online veröffentlicht: 29. Apr. 2020
Seitenbereich: 35 - 43
Eingereicht: 17. Feb. 2020
Akzeptiert: 02. Apr. 2020
DOI: https://doi.org/10.2478/acb-2020-0004
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© 2020 Lisa Moncrieff, Ievgeniia Kocherova, Artur Bryja, Wiesława Kranc, Joanna Perek, Piotr Celichowski, Magdalena Kulus, Bartosz Kempisty, Paul Mozdziak, Michal Jeseta, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Heat map representations of differentially expressed genes belonging to the “hemopoietic or lymphoid organ development” and “immune system development” GO BP terms. Arbitrary signal intensity acquired from microarray analysis is represented by colours (green, higher; red, lower expression). Log2 signal intensity values for any single gene were resized to Row Z-Score scale (from -2, the lowest expression to +2, the highest expression for single gene)
Heat map representations of differentially expressed genes belonging to the “hemopoietic or lymphoid organ development” and “immune system development” GO BP terms. Arbitrary signal intensity acquired from microarray analysis is represented by colours (green, higher; red, lower expression). Log2 signal intensity values for any single gene were resized to Row Z-Score scale (from -2, the lowest expression to +2, the highest expression for single gene)

Figure 2

The circle plot showing the differently expressed genes and z-score “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The outer circle shows a scatter plot for each term of the fold change of the assigned genes. Red circles display down- regulation and green ones up- regulation. The inner circle shows the z-score of each GO BP term. The width of each bar corresponds to the number of genes within GO BP term and the color corresponds to the z-score
The circle plot showing the differently expressed genes and z-score “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The outer circle shows a scatter plot for each term of the fold change of the assigned genes. Red circles display down- regulation and green ones up- regulation. The inner circle shows the z-score of each GO BP term. The width of each bar corresponds to the number of genes within GO BP term and the color corresponds to the z-score

Figure 3

The representation of the mutual relationship between differently expressed genes that belongs to “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The ribbons indicate which gene belongs to which categories. The middle circle represents logarithm from fold change (LogFC) between before IVM and after IVM respectively. The genes were sorted by logFC from most to least changed gene
The representation of the mutual relationship between differently expressed genes that belongs to “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The ribbons indicate which gene belongs to which categories. The middle circle represents logarithm from fold change (LogFC) between before IVM and after IVM respectively. The genes were sorted by logFC from most to least changed gene

Figure 4

STRING-generated interaction network between genes that belongs to the “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The intensity of the edges reflects the strength of interaction score
STRING-generated interaction network between genes that belongs to the “hemopoietic or lymphoid organ development” and “immune system development” GO BP Terms. The intensity of the edges reflects the strength of interaction score
eISSN:
2544-3577
Sprache:
Englisch
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Fachgebiete der Zeitschrift:
Biologie, Molekularbiologie, Biochemie
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