<abstract xmlns="http://www.w3.org/1999/xhtml">A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields. The <italic>in vivo</italic> biodistribution of 99mTc-AEDP has been investigated and compared with two reference compounds Tc-99m methylene diphosphonate (99mTc-MDP) and Tc-99m (1-hydroxyethylidene) diphosphonate (99mTc-HEDP). The biodistribution studies have demonstrated a high uptake of the radiotracer 99mTc-AEDP in the bone and a rapid clearance from the blood (such as the two technetium-labeled bone imaging agents in current use: 99mTc-MDP and 99mTc-HEDP). Additionally, the scintigraphic images of 99mTc-AEDP in normal rats have revealed high selective skeletal uptake.</abstract>

A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields. The in vivo biodistribution of 99mTc-AEDP has been investigated and compared with two reference compounds Tc-99m methylene diphosphonate (99mTc-MDP) and Tc-99m (1-hydroxyethylidene) diphosphonate (99mTc-HEDP). The biodistribution studies have demonstrated a high uptake of the radiotracer 99mTc-AEDP in the bone and a rapid clearance from the blood (such as the two technetium-labeled bone imaging agents in current use: 99mTc-MDP and 99mTc-HEDP). Additionally, the scintigraphic images of 99mTc-AEDP in normal rats have revealed high selective skeletal uptake.

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Radioisotopes Division, Radioisotopes Department, Atomic Energy Commission of Syria (AECS), P. O. Box 6091, Damascus, Syrian Arab Republic, Tel.: +963(11) 213 2580, Fax: +963(11) 611 2289

Nukleonika

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A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling...

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Online veröffentlicht: 17. März 2016

Seitenbereich: 69 - 74

Eingereicht: 10. Aug. 2015

Akzeptiert: 18. Jan. 2016

DOI: https://doi.org/10.1515/nuka-2016-0013

Schlüsselwörter
aminoethylidenediphosphonic acid, biodistribution, bisphosphonates, bone imaging agent, radiolabeling

© 2016 Thaer Assaad, published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)

Online veröffentlicht: 17. März 2016

Seitenbereich: 69 - 74

Eingereicht: 10. Aug. 2015

Akzeptiert: 18. Jan. 2016

DOI: https://doi.org/10.1515/nuka-2016-0013

Schlüsselwörteraminoethylidenediphosphonic acid, biodistribution, bisphosphonates, bone imaging agent, radiolabeling

© 2016 Thaer Assaad, published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
aminoethylidenediphosphonic acid, biodistribution, bisphosphonates, bone imaging agent, radiolabeling