<abstract xmlns="http://www.w3.org/1999/xhtml">A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.</abstract>

A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.

Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module

Heavy Ion Laboratory, University of Warsaw, 5a Pasteura Str., 02-093 Warsaw, Poland, Tel.: +48 22 554 6214

Faculty of Physics, University of Warsaw, 69 Hoża Str., 02-093 Warsaw, Poland

Nukleonika

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis of C-methionine through gas phase iodination using Synthra MeI synthesis module

A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2...

Synthesis of ¹¹C-methionine through gas phase iodination using Synthra MeI_Plus synthesis module

Online veröffentlicht: 17. März 2016

Seitenbereich: 29 - 33

Eingereicht: 07. Aug. 2014

Akzeptiert: 28. Juli 2015

DOI: https://doi.org/10.1515/nuka-2016-0007

Schlüsselwörter
C-methionine, C-radiopharmaceuticals, gas phase iodination

© 2016 Krzysztof Kilian et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module

Online veröffentlicht: 17. März 2016

Seitenbereich: 29 - 33

Eingereicht: 07. Aug. 2014

Akzeptiert: 28. Juli 2015

DOI: https://doi.org/10.1515/nuka-2016-0007

SchlüsselwörterC-methionine, C-radiopharmaceuticals, gas phase iodination

© 2016 Krzysztof Kilian et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis of ¹¹C-methionine through gas phase iodination using Synthra MeI_Plus synthesis module

Schlüsselwörter
C-methionine, C-radiopharmaceuticals, gas phase iodination