<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic exposure, and the correction of the detected changes. In the work, the structural and metabolic reorganization of myocardium was studied by way of general histological, histochemical and electron microscopic techniques. Herein, administration of Unithiolum reduces the severity of reactions to toxic effects of mercury salts: decreases the intensity of inflammation in the myocardium, improves microcirculation, connective tissue and mitochondrial membranes status and reduces cardiomyocytes apoptosis. Quercetinum has a normalizing effect on the myocardium structure, reduces energy imbalance in the myocardium, and stabilizes mitochondrial membranes. Both Unithiolum and Quercetinum promote intracellular ultrastructures recovery in cardiac myocytes and in endothelial cells, and enhance the regeneration of myofibrils.</p></abstract>

The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic exposure, and the correction of the detected changes. In the work, the structural and metabolic reorganization of myocardium was studied by way of general histological, histochemical and electron microscopic techniques. Herein, administration of Unithiolum reduces the severity of reactions to toxic effects of mercury salts: decreases the intensity of inflammation in the myocardium, improves microcirculation, connective tissue and mitochondrial membranes status and reduces cardiomyocytes apoptosis. Quercetinum has a normalizing effect on the myocardium structure, reduces energy imbalance in the myocardium, and stabilizes mitochondrial membranes. Both Unithiolum and Quercetinum promote intracellular ultrastructures recovery in cardiac myocytes and in endothelial cells, and enhance the regeneration of myofibrils.

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

О.О. Bogomolets National Medical University, Kyiv,

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic...

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

Online veröffentlicht: 23. Jan. 2017

Seitenbereich: 167 - 170

Eingereicht: 28. Juni 2016

Akzeptiert: 29. Juli 2016

DOI: https://doi.org/10.1515/cipms-2016-0035

Schlüsselwörter
myocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum

© 2016 Kaminsky F. Rostislav et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

Online veröffentlicht: 23. Jan. 2017

Seitenbereich: 167 - 170

Eingereicht: 28. Juni 2016

Akzeptiert: 29. Juli 2016

DOI: https://doi.org/10.1515/cipms-2016-0035

Schlüsselwörtermyocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum

© 2016 Kaminsky F. Rostislav et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
myocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum