<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic exposure, and the correction of the detected changes. In the work, the structural and metabolic reorganization of myocardium was studied by way of general histological, histochemical and electron microscopic techniques. Herein, administration of Unithiolum reduces the severity of reactions to toxic effects of mercury salts: decreases the intensity of inflammation in the myocardium, improves microcirculation, connective tissue and mitochondrial membranes status and reduces cardiomyocytes apoptosis. Quercetinum has a normalizing effect on the myocardium structure, reduces energy imbalance in the myocardium, and stabilizes mitochondrial membranes. Both Unithiolum and Quercetinum promote intracellular ultrastructures recovery in cardiac myocytes and in endothelial cells, and enhance the regeneration of myofibrils.</p></abstract>

The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic exposure, and the correction of the detected changes. In the work, the structural and metabolic reorganization of myocardium was studied by way of general histological, histochemical and electron microscopic techniques. Herein, administration of Unithiolum reduces the severity of reactions to toxic effects of mercury salts: decreases the intensity of inflammation in the myocardium, improves microcirculation, connective tissue and mitochondrial membranes status and reduces cardiomyocytes apoptosis. Quercetinum has a normalizing effect on the myocardium structure, reduces energy imbalance in the myocardium, and stabilizes mitochondrial membranes. Both Unithiolum and Quercetinum promote intracellular ultrastructures recovery in cardiac myocytes and in endothelial cells, and enhance the regeneration of myofibrils.

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

О.О. Bogomolets National Medical University, Kyiv,

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The article is devoted to the characteristics of the myocardium restructuring under the influence of 0.01 LD50 mercury (II) chloride, in rats, under subchronic...

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

Published Online: Jan 23, 2017

Page range: 167 - 170

Received: Jun 28, 2016

Accepted: Jul 29, 2016

DOI: https://doi.org/10.1515/cipms-2016-0035

Keywords
myocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum

© 2016 Kaminsky F. Rostislav et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Status of rats myocardium under subchronic mercury exposure and its pharmacological correction

Published Online: Jan 23, 2017

Page range: 167 - 170

Received: Jun 28, 2016

Accepted: Jul 29, 2016

DOI: https://doi.org/10.1515/cipms-2016-0035

Keywordsmyocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum

© 2016 Kaminsky F. Rostislav et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
myocardium, morphometry, salts of heavy metals, mercury, mercury (II) chloride, micromercurialism, ultramicroscopy, histochemistry, Unithiolum, Quercetinum