Über diesen Artikel
Artikel-Kategorie: Review
Online veröffentlicht: 09. Juli 2016
Seitenbereich: 5 - 14
DOI: https://doi.org/10.1515/bjmg-2015-0080
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© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
RNA role in several neurological diseases_
| Disease | Cause |
|---|---|
| Alzheimer’s disease | TDP-43, mir-137/181b, BACE1AS |
| Down syndrome | TDP-43 |
| Frontotemporal lobar dementia | TDP-43 |
| Amyotrophic lateral sclerosis | TDP-43, mir-206 |
| Familial British dementia | TDP-43 |
| Parkinson’s disease | TDP-43, BC200, SOX20T, mir-34b/c, mir-153 |
| Huntington’s disease | HAR1, DGCR5, TDP-43, FUS/TLS, TUG1, NEAT 1, toxic RNA, mir-132, mir-7, mir-34b |
| Spinocerebellar ataxia 1, 2, 3, 4 | FUS/TLS |
| Spinocerebellar ataxia 10, 12 | Toxic RNA, RAN (repeat associated non ATG translation), expansion in non coding region |
| Dentatorubral-pallidoluysian atrophy | FUS/TLS |
| Myopathies | TDP-43 |
| Fragile X tremor ataxia syndrome | Antisense transcription, expansion in non coding region |
| X-linked mental retardation | UPF3B mutation |
| Autism | 7q22-q33 (non coding RNA) |
| Spinal muscular atrophy | Mutation in SMN2 |
| Spinocerebellar ataxia | Non coding RNA |
| Myotonic dystrophy type 1 (DM1) | RAN (repeat associated non ATG translation), expansion in non coding region |
| Myotonic dystrophy type 2 (DM2) | Expansion in non coding region |