<abstract xmlns="http://www.w3.org/1999/xhtml">The topic of charge-transfer (CT) complexation of vital drugs has attracted considerable attention in recent years owing to their significant physical and chemical properties. In this study, CT complexes derived from the reaction of the anti-hyperuricemic drug allopurinol (Allop) with organic p-acceptors [(picric acid (PA), dichlorodicyanobenzoquinone (DDQ) and chloranil (CHL)] were prepared, isolated and characterized by a range of physicochemical methods, such as IR, Raman, 1H NMR and 13C NMR spectroscopy. The stoichiometry of the complexes was verified by elemental analysis. The results show that all complexes that were formed were based on a 1:1 stoichiometric ratio. This study suggests that the complexation of Allop with either the DDQ or CHL acceptor leads to a direct p®p* transition, whereas the molecules of Allop and PA are linked by intermolecular hydrogen- bonding interactions.</abstract>

The topic of charge-transfer (CT) complexation of vital drugs has attracted considerable attention in recent years owing to their significant physical and chemical properties. In this study, CT complexes derived from the reaction of the anti-hyperuricemic drug allopurinol (Allop) with organic p-acceptors [(picric acid (PA), dichlorodicyanobenzoquinone (DDQ) and chloranil (CHL)] were prepared, isolated and characterized by a range of physicochemical methods, such as IR, Raman, 1H NMR and 13C NMR spectroscopy. The stoichiometry of the complexes was verified by elemental analysis. The results show that all complexes that were formed were based on a 1:1 stoichiometric ratio. This study suggests that the complexation of Allop with either the DDQ or CHL acceptor leads to a direct p®p* transition, whereas the molecules of Allop and PA are linked by intermolecular hydrogen- bonding interactions.

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies

Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974, Taif, Saudi Arabia

Department of Chemistry, Faculty of Science, Port Said University, Port Said,

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig,

Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974, Taif,

Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451,

Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Peptide Chemistry Department, Chemical Industries Research Division National Research Centre, 12622-Dokki, Cairo,

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, H NMR and C NMR spectroscopies

The topic of charge-transfer (CT) complexation of vital drugs has attracted considerable attention in recent years owing to their significant physical and...

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, ¹H NMR and ¹³C NMR spectroscopies

Online veröffentlicht: 15. Okt. 2016

Seitenbereich: 533 - 542

Akzeptiert: 25. Juli 2016

DOI: https://doi.org/10.1515/acph-2016-0045

Schlüsselwörter
allopurinol, p-acceptor, charge-transfer, proton- transfer

© by Moamen S. Refat

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies

Online veröffentlicht: 15. Okt. 2016

Seitenbereich: 533 - 542

Akzeptiert: 25. Juli 2016

DOI: https://doi.org/10.1515/acph-2016-0045

Schlüsselwörterallopurinol, p-acceptor, charge-transfer, proton- transfer

© by Moamen S. Refat

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, ¹H NMR and ¹³C NMR spectroscopies

Schlüsselwörter
allopurinol, p-acceptor, charge-transfer, proton- transfer