<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.</p></abstract>

The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.

A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride

Department of Pharmaceutical Technology Charles University in Prague Faculty of Pharmacy in Hradec Králové Czech Republic

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel...

A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride

Online veröffentlicht: 29. Juni 2016

Seitenbereich: 433 - 441

Akzeptiert: 11. Jan. 2016

DOI: https://doi.org/10.1515/acph-2016-0034

Schlüsselwörter
tramadol hydrochloride, hydrophilic matrix tablets, coprocessed dry binder, hypromellose, energy profile of compression, tensile strength of tablets

© by Jitka Mužíková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride

Online veröffentlicht: 29. Juni 2016

Seitenbereich: 433 - 441

Akzeptiert: 11. Jan. 2016

DOI: https://doi.org/10.1515/acph-2016-0034

Schlüsselwörtertramadol hydrochloride, hydrophilic matrix tablets, coprocessed dry binder, hypromellose, energy profile of compression, tensile strength of tablets

© by Jitka Mužíková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
tramadol hydrochloride, hydrophilic matrix tablets, coprocessed dry binder, hypromellose, energy profile of compression, tensile strength of tablets