<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A pharmacokinetic comparison and conformational stability study of <italic>S</italic>-oxiracetam (<italic>S</italic>-ORT) and <italic>R</italic>-oxiracetam (<italic>R</italic>-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of <italic>S</italic>-ORT were significantly higher than <italic>R</italic>-ORT 1.5 and 2 h after administration; the <italic>AUC</italic><sub>0-∞</sub> of <italic>S</italic>-ORT after oral administration tended to be higher than that of <italic>R</italic>-ORT, which showed that the different effects between <italic>S</italic>-ORT and <italic>R</italic>-ORT may be partly associated with their distinctive absorption at least.</p></abstract>

A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the possible mechanism of different effects of two oxiracetam enantiomers through a random crossover design. After drug administration to beagle dogs, blood samples were collected at different time points for pharmacokinetic analysis using the UPLC-ESI-MS/MS method. Parts of plasma samples were used for conformation transformation studies using a normal phase high performance liquid chromatographic (NP HPLC) method. The study showed that oxiracetam enantiomers maintained their original conformation when administered orally to beagle dogs. Concentrations of S-ORT were significantly higher than R-ORT 1.5 and 2 h after administration; the AUC0-∞ of S-ORT after oral administration tended to be higher than that of R-ORT, which showed that the different effects between S-ORT and R-ORT may be partly associated with their distinctive absorption at least.

Pharmacokinetic comparisons of <italic>S</italic>-oxiracetam and <italic>R</italic>-oxiracetam in beagle dogs

Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210000, China

Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui Province, China

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Pharmacokinetic comparisons of -oxiracetam and -oxiracetam in beagle dogs

A pharmacokinetic comparison and conformational stability study of S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT) in beagle dogs was used to investigate the...

Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs

Online veröffentlicht: 28. Mai 2016

Seitenbereich: 279 - 287

Akzeptiert: 27. Okt. 2015

DOI: https://doi.org/10.1515/acph-2016-0013

Schlüsselwörter
-oxiracetam, -oxiracetam, conformation, pharmacokinetics, beagle dogs

© 2016 Wusan Wang et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs

Online veröffentlicht: 28. Mai 2016

Seitenbereich: 279 - 287

Akzeptiert: 27. Okt. 2015

DOI: https://doi.org/10.1515/acph-2016-0013

Schlüsselwörter-oxiracetam, -oxiracetam, conformation, pharmacokinetics, beagle dogs

© 2016 Wusan Wang et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
-oxiracetam, -oxiracetam, conformation, pharmacokinetics, beagle dogs