<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against <italic>Borrelia burgdorferi</italic> in suspension (<italic>in vitro</italic>) and in cell line cultures (<italic>in vivo</italic>). In the suspension method, 0.01% octenidine at 20°C and 35°C was bactericidal to <italic>Borrelia afzeli</italic>; <italic>Borrelia garini</italic>, <italic>B. burgdorferi</italic> sensu stricto after 5 minutes treatment. Increase of the temperature to 35°C speed up the bactericidal effect to 1 minute. The bactericidal action of octenidine towards <italic>B. burgdorferi</italic> spirochetes growing in fibroblasts was less effective and needed a longer time to kill them than in the suspension.</p>
</abstract>

The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against Borrelia burgdorferi in suspension (in vitro) and in cell line cultures (in vivo). In the suspension method, 0.01% octenidine at 20°C and 35°C was bactericidal to Borrelia afzeli; Borrelia garini, B. burgdorferi sensu stricto after 5 minutes treatment. Increase of the temperature to 35°C speed up the bactericidal effect to 1 minute. The bactericidal action of octenidine towards B. burgdorferi spirochetes growing in fibroblasts was less effective and needed a longer time to kill them than in the suspension.

Bactericidal Activity of Octenidine to Various Genospecies of <italic>Borrelia burgdorferi</italic>, Sensu Lato Spirochetes <italic>in Vitro</italic> and <italic>in Vivo</italic>

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Bactericidal Activity of Octenidine to Various Genospecies of , Sensu Lato Spirochetes  and 

The aim of our studies was to invent a reliable method for detection of the bactericidal activity of disinfectants against Borrelia burgdorferi in suspension...

Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitro and in Vivo

Published Online: Jun 28, 2017

Page range: 259 - 263

Received: Aug 11, 2016

Accepted: Jan 27, 2017

DOI: https://doi.org/10.5604/01.3001.0010.7874

Keywords
octenidine hydrochloride, bactericidal activity

© 2017 STANISŁAWA TYLEWSKA-WIERZBANOWSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Bactericidal Activity of Octenidine to Various Genospecies of Borrelia burgdorferi, Sensu Lato Spirochetes in Vitro and in Vivo

Published Online: Jun 28, 2017

Page range: 259 - 263

Received: Aug 11, 2016

Accepted: Jan 27, 2017

DOI: https://doi.org/10.5604/01.3001.0010.7874

Keywordsoctenidine hydrochloride, bactericidal activity

© 2017 STANISŁAWA TYLEWSKA-WIERZBANOWSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
octenidine hydrochloride, bactericidal activity