<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1004.501_s_001_w2aab3b7b9b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Although the pathophysiology and treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are well established, the incidence and outcomes of ALI have not been extensively reported. Variations in healthcare systems, demographics, socioeconomics, and levels of intensive care units (ICU) may explain remarkable differences in outcomes reported.</p></sec><sec id="j_1905-7415.1004.501_s_002_w2aab3b7b9b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To evaluate the incidence and outcomes of ALI/ARDS at the surgical ICU (SICU) at Siriraj Hospital of Mahidol University, Bangkok.</p></sec><sec id="j_1905-7415.1004.501_s_003_w2aab3b7b9b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>We included patients aged ≥18 years admitted to the general SICU between June 1, 2010 and May 31, 2013 in this prospective, cohort observational study. All patients required ≥24 h of ventilatory support. The study outcomes were the incidence of ALI/ARDS, SICU length of stay, and mortality rate.</p></sec><sec id="j_1905-7415.1004.501_s_004_w2aab3b7b9b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Of 2523 patients admitted to the SICU, 495 (20%) required ≥24 h ventilatory support, and 15 (3%) developed ALI/ARDS. ALI/ARDS occurred on day 2 of ventilatory support. ARDS was caused by sepsis and pneumonia. The patients who developed ALI/ARDS had a higher APACHE II score (<italic>P</italic> = 0.001) and end-stage renal disease (<italic>P</italic> = 0.01). Pneumonia and acute kidney injury were more severe in patients with ALI and ARDS (40% vs 9%, <italic>P</italic> = 0.002; 33% vs 10%, <italic>P</italic> = 0.02, respectively). Ventilatory support duration, SICU lengths of stay and hospital mortality were higher in the ALI/ARDS group.</p></sec><sec id="j_1905-7415.1004.501_s_005_w2aab3b7b9b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>The incidence of ALI/ARDS in the SICU was low, but the mortality rate was high. A larger sample size is necessary to identify independent risk factors for ALI/ARDS.</p></sec></abstract>

BackgroundAlthough the pathophysiology and treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are well established, the incidence and outcomes of ALI have not been extensively reported. Variations in healthcare systems, demographics, socioeconomics, and levels of intensive care units (ICU) may explain remarkable differences in outcomes reported.ObjectivesTo evaluate the incidence and outcomes of ALI/ARDS at the surgical ICU (SICU) at Siriraj Hospital of Mahidol University, Bangkok.MethodsWe included patients aged ≥18 years admitted to the general SICU between June 1, 2010 and May 31, 2013 in this prospective, cohort observational study. All patients required ≥24 h of ventilatory support. The study outcomes were the incidence of ALI/ARDS, SICU length of stay, and mortality rate.ResultsOf 2523 patients admitted to the SICU, 495 (20%) required ≥24 h ventilatory support, and 15 (3%) developed ALI/ARDS. ALI/ARDS occurred on day 2 of ventilatory support. ARDS was caused by sepsis and pneumonia. The patients who developed ALI/ARDS had a higher APACHE II score (P = 0.001) and end-stage renal disease (P = 0.01). Pneumonia and acute kidney injury were more severe in patients with ALI and ARDS (40% vs 9%, P = 0.002; 33% vs 10%, P = 0.02, respectively). Ventilatory support duration, SICU lengths of stay and hospital mortality were higher in the ALI/ARDS group.ConclusionsThe incidence of ALI/ARDS in the SICU was low, but the mortality rate was high. A larger sample size is necessary to identify independent risk factors for ALI/ARDS.

Incidence and outcomes of acute lung injury in the surgical intensive care unit of a tertiary care hospital in Bangkok, Thailand

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundAlthough the pathophysiology and treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are well established, the...

Incidence and outcomes of acute lung injury in the surgical intensive care unit of a tertiary care hospital in Bangkok, Thailand

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 379 - 385

DOI: https://doi.org/10.5372/1905-7415.1004.501

Keywords
Acute lung injury, acute respiratory distress syndrome, critically illness, incidence, surgical ICU

© 2016 Onuma Chaiwat, Worawan Suwannasri, Jedsadayoot Sak-aroonchai, Sawita Kanavitoon, Annop Piriyapathsom, Chainida Sirisatjawat, Nusara Kulana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Incidence and outcomes of acute lung injury in the surgical intensive care unit of a tertiary care hospital in Bangkok, Thailand

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 379 - 385

DOI: https://doi.org/10.5372/1905-7415.1004.501

KeywordsAcute lung injury, acute respiratory distress syndrome, critically illness, incidence, surgical ICU

© 2016 Onuma Chaiwat, Worawan Suwannasri, Jedsadayoot Sak-aroonchai, Sawita Kanavitoon, Annop Piriyapathsom, Chainida Sirisatjawat, Nusara Kulana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Acute lung injury, acute respiratory distress syndrome, critically illness, incidence, surgical ICU