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The anti proliferative effect of palm oil γ-tocotrienol involves alterations in MEK-2 and ERK-2 protein expressions in CaSki cells


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1. Robert PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007; 26:3291-310.10.1038/sj.onc.1210422Open DOISearch in Google Scholar

2. Khan TA, Cesario B, Ruel M, Voisine P, Sellke FW. Mitogen-activated protein kinase pathways and cardiac surgery. J Thorac Cardiovasc Surg. 2004; 127: 806-11.10.1016/j.jtcvs.2003.04.001Search in Google Scholar

3. Sundram K, Sambanthamurthi R, Tan YA. Palm oil chemistry and nutrition. Asia Pac J Clin Nutr. 2003; 12: 355-62.Search in Google Scholar

4. Miyazawa T, Shibata A, Sookwong P, Kawakami Y, Eitsuka T, Asai A, Oikawa S, Nakagawa K. Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). J Nutr Biochem. 2009; 20:79-86.10.1016/j.jnutbio.2008.09.003Open DOISearch in Google Scholar

5. Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and? γ-tocotrienol. Free Radic Biol Med. 1991; 10:263-75.10.1016/0891-5849(91)90033-YSearch in Google Scholar

6. Divisi D, Di Tommaso S, Salvemini S, Garramone M, Crisci R. Diet and cancer. Acta Biomed. 2006; 77: 118-23.Search in Google Scholar

7. Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer. 1998; 82:395-402.10.1002/(SICI)1097-0142(19980115)82:2<403::AID-CNCR21>3.0.CO;2-1Search in Google Scholar

8. Weinstein SJ, Wright ME, Pietinen P, King I, Tan C, Taylor PR, Virtamo J, Albanes D. Serum alphatocopherol and gamma-tocopherol in relation to prostate cancer risk in a prospective study. J Nat Cancer Inst. March 2005; 97:396-9.10.1093/jnci/dji045Open DOISearch in Google Scholar

9. Chin SF, Abdul Hamid NA, Mazlan M, Mohd Yusof YA, Wan Ngah WZ. Reduction of DNA damage in older healthy adults by TriE tocotrineol supplementation. Nutrition 2008; 24(1):1-1010.1016/j.nut.2007.08.006Open DOISearch in Google Scholar

10. Lunec J, Halligan E, Mistry N, Karakoula K. Effect of vitamin E on gene expression changes in diet-related carcinogenesis. Ann NY Acad Sci. 2004; 1031:169-83.10.1196/annals.1331.016Search in Google Scholar

11. Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang XD. Combined antioxidant (β-carotene, α-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis. July 2006; 27:1410-9.10.1093/carcin/bgi340Open DOISearch in Google Scholar

12. Agarwal MK, Agarwal ML, Athar M, Gupta S. Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. Cell Cycle. Feb 2004; 3:205-11.Search in Google Scholar

13. Srivastava JK, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. [My paper] Biochem Biophysics Res Commun. 2006; 346:447-53.10.1016/j.bbrc.2006.05.147Search in Google Scholar

14. Kannappan R, Ravindran J, Prasad S, Sung B, Yadav VR, Reuter S, Chaturvedi MM, Aggarwal BB. γ-Tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signalregulated kinase/p53-mediated upregulation of death receptors. Mol Cancer Ther. August 2010; 9: 2196-207.10.1158/1535-7163.MCT-10-027720682650Open DOISearch in Google Scholar

15. Packer L, Weber S, Rimbach G. Molecular aspects of alpha tocotrienol antioxidant action and cell signaling. J Nutr. 2001; 131:369S-73S.10.1093/jn/131.2.369S11160563Search in Google Scholar

16. Donapaty S, Louis S, Horvath E, Kun J, Sebti SM, Malafa MP. RRR-α-tocopherol succinate downregulates oncogenic Ras signaling. Mol Cancer Ther. 2006; 5:309-16.10.1158/1535-7163.MCT-05-033016505104Open DOISearch in Google Scholar

17. Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. γ- Tocopherol or combinations of vitamin E forms induces cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci USA. 2004; 101:17825-30.10.1073/pnas.040834010253558515596715Open DOISearch in Google Scholar

eISSN:
1875-855X
Language:
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Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine