Dissociation between Animal and Clinical Studies. Where Do We Go Wrong?

1 Hackam DG, Redelmeier DA. Translation of research evidence from animals to humans. JAMA 2006;296:1731–2. HackamDG RedelmeierDA Translation of research evidence from animals to humans JAMA 2006 296 1731 2 10.1001/jama.296.14.1731 Search in Google Scholar

2 Ledford H. Translational research: 4 ways to fix the clinical trial. Nature 2011;477:526–8. LedfordH Translational research: 4 ways to fix the clinical trial Nature 2011 477 526 8 10.1038/477526a Search in Google Scholar

3 Jüni P, Nartey L, Reichenbach S, et al. Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 2004;364:2021–9. JüniP NarteyL ReichenbachS Risk of cardiovascular events and rofecoxib: cumulative meta-analysis Lancet 2004 364 2021 9 10.1016/S0140-6736(04)17514-4 Search in Google Scholar

4 Stolley PD. Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma. Am Rev Respir Dis 1972;105:883–90. StolleyPD Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma Am Rev Respir Dis 1972 105 883 90 Search in Google Scholar

5 Schardein JL. Drugs as Teratogens 1976; CRC Press, Cleveland, Ohio; p. 49. SchardeinJL Drugs as Teratogens 1976 CRC Press Cleveland, Ohio 49 Search in Google Scholar

6 Van Norman GA. Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach? JACC Basic Transl Sci 2019;4:845–54. Van NormanGA Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach? JACC Basic Transl Sci 2019 4 845 54 10.1016/j.jacbts.2019.10.008697855831998852 Search in Google Scholar

7 Wolpert L. Review of „Animal models in the light of evolution” by Niall Shanks, Ph.D., and C. Ray Greek, M.D. Philos Ethics Humanit Med 2010;5:12. WolpertL Review of „Animal models in the light of evolution” by Niall Shanks, Ph.D., and C. Ray Greek, M.D. Philos Ethics Humanit Med 2010 5 12 10.1186/1747-5341-5-12 Search in Google Scholar

8 Mergenthaler P, Meisel A. Animal models: value and translational potency in Principles of translational science in medicine – from bench to bedside, 2nd Ed.; Academic Press 2015; p. 83–90. MergenthalerP MeiselA Animal models: value and translational potency in Principles of translational science in medicine – from bench to bedside 2nd Ed. Academic Press 2015 83 90 10.1016/B978-0-12-800687-0.00007-4 Search in Google Scholar

9 Shim J, Al-Mashhadi RH, Sørensen CB, et al. Large animal models of atherosclerosis – new tools for persistent problems in cardiovascular medicine. J Pathol 2016;238:257–66. ShimJ Al-MashhadiRH SørensenCB Large animal models of atherosclerosis – new tools for persistent problems in cardiovascular medicine J Pathol 2016 238 257 66 10.1002/path.464626414760 Search in Google Scholar

10 Perrin S. Preclinical research: Make mouse studies work. Nature 2014;507:423–5. PerrinS Preclinical research: Make mouse studies work Nature 2014 507 423 5 10.1038/507423a24678540 Search in Google Scholar

11 Şerban RC, Scridon A. Data linking diabetes mellitus and atrial fibrillation-how strong is the evidence? From epidemiology and pathophysiology to therapeutic implications. Can J Cardiol 2018;34:1492–502. ŞerbanRC ScridonA Data linking diabetes mellitus and atrial fibrillation-how strong is the evidence? From epidemiology and pathophysiology to therapeutic implications Can J Cardiol 2018 34 1492 502 10.1016/j.cjca.2018.08.01830404752 Search in Google Scholar

12 Bebarta B, Luyten D, Heard K. Emergency medicine animal research: does use of randomization and blinding affect the results? Acad Emerg Med 2003;10:684–7. BebartaB LuytenD HeardK Emergency medicine animal research: does use of randomization and blinding affect the results? Acad Emerg Med 2003 10 684 7 10.1111/j.1553-2712.2003.tb00056.x12782533 Search in Google Scholar

13 Perel P, Roberts I, Sena E, W et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ 2007;334:197. PerelP RobertsI SenaEW Comparison of treatment effects between animal experiments and clinical trials: systematic review BMJ 2007 334 197 10.1136/bmj.39048.407928.BE178197017175568 Search in Google Scholar

14 Hausenloy DJ, Erik Bøtker H, Condorelli G, et al. Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res 2013;98:7–27. HausenloyDJ Erik BøtkerH CondorelliG Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology Cardiovasc Res 2013 98 7 27 10.1093/cvr/cvt00423334258 Search in Google Scholar

15 Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 2008;105:11915–20. Frank-KamenetskyM GrefhorstA AndersonNN Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc Natl Acad Sci U S A 2008 105 11915 20 10.1073/pnas.0805434105257531018695239 Search in Google Scholar

16 Ferreira GS, Veening-Griffioen DH, Boon WPC, et al. A standardised framework to identify optimal animal models for efficacy assessment in drug development. PLoS One 2019;14:e0218014. FerreiraGS Veening-GriffioenDH BoonWPC A standardised framework to identify optimal animal models for efficacy assessment in drug development PLoS One 2019 14 e0218014 10.1101/382366 Search in Google Scholar