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Immunoglobulins content in colostrum, transitional and mature milk of Bangladeshi mothers: Influence of parity and sociodemographic characteristics

Hashemi Akhter
Hashemi Akhter
, 
Farina Aziz
Farina Aziz
, 
Fahim R. Ullah
Fahim R. Ullah
, 
Monira Ahsan
Monira Ahsan
 and 
Sheikh N. Islam
Sheikh N. Islam
   | Jan 29, 2021
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Article Category: Original paper
Published Online: Jan 29, 2021
Page range: 8 - 15
DOI: https://doi.org/10.34763/jmotherandchild.20202403.2032.d-20-00001
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© 2020 Hashemi Akhter et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Immunoglobulins (IgA, IgG and IgM) concentration (g/L) in colostrum, transitional and mature milk.

Immunoglobulins (n = 38) Concentration (g/L) of immunoglobulins in human milk Statistics
Mean ± SD 95% CI (lower-upper) Ranges t-statistics Correlation co-efficient
IgA
Colostruma 5.92 ± 1.5 5.45–6.40 3.16–8.97 tab = 7.15 Pab = 0.000** rab = 0.028 Pab = 0.94
Transitional milkb 3.85 ± 0.64 3.64–4.05 1.35–4.69 tbc = 1.02 Pbc = 0.32 rbc = 0.33 Pbc = 0.04*
Mature milkc 3.72 ± 0.68 3.50–3.93 1.79–4.43 tac = 8.28 Pac = 0.000** rac = 0.001 Pac = 0.543
IgG
Colostruma 0.10 ± 0.03 0.09–0.11 0.04–0.17 tab = =4.03 Pab = 0.000** rab = 0.002 Pab = 0.537
Transitional milkb 0.12 ± 0.02 0.11–0.12 0.08–0.15 tbc = 1.00 Pbc = 0.32 rbc = 0.51 Pbc = 0.001**
Mature milkc 0.11 ± 0.02 0.11–0.12 0.07–0.17 tac = 2.66 Pac = 0.011* rac = 0.005 Pac = 0.654
IgM
Colostruma 0.44 ± 0.10 0.41–0.47 0.23–0.59 tab = 21.37 Pab = 0.000** rab = 0.023 Pab = 0.345
Transitional milkb 0.10 ± 0.02 0.09–0.10 0.04–0.14 tbc = 1.28 Pbc = 0.21 rbc = 0.34 Pbc = 0.04*
Mature milkc 0.09 ± 0.02 0.08–0.10 0.06–0.15 tac = 20.71 Pac = 0.000** rac = 0.005 Pac = 0.345

Association of immunoglobulins concentration at different stages of lactation with maternal characteristics and family income.

Maternal characteristics (n = 38) % (n) Colostrum (g/L) Transitional milk (g/L) Mature milk (g/L)
Mean ± SD Mean ± SD Mean ± SD
IgA IgG IgM IgA IgG IgM IgA IgG IgM
Age (years)
18–20 34.0 (13) 6.04 ± 1.3 0.10 ± 0.03 0.42 ± 0.1 3.81 ± 0.5 0.13 ± 0.02 0.10 ± 0.02 3.78 ± 0.8 0.12 ± 0.02 0.09 ± 0.02
21–25 37.0 (14) 6.01 ± 1.4 0.10 ± 0.03 0.42 ± 0.1 3.84 ± 0.8 0.12 ± 0.02 0.10 ± 0.02 3.72 ± 0.7 0.11± 0.02 0.09 ± 0.02
≥26 29.0 (11) 5.9 ± 1.5 0.10 ± 0.02 0.41 ± 0.1 3.82 ± 0.6 0.12 ± 0.02 0.10 ± 0.03 3.80 ± 0.7 0.11 ± 0.02 0.09 ± 0.03
P-value 0.98 0.74 0.19 0.78 0.69 0.94 0.99 0.57 0.39
Parity
Primiparous 34.0 (13) 6.58 ± 1.3 0.10 ± 0.022 0.44 ± 0.1 3.73 ± 0.9 0.13 ± 0.02 0.11 ± 0.02 3.78 ± 0.8 0.12 ± 0.02 0.09 ± 0.03
Multiparous 66.0 (25) 5.58 ± 1.5 0.10 ± 0.03 0.44 ± 0.1 3.91 ± 0.5 0.11 ± 0.02 0.09 ± 0.02 3.69 ± 0.6 0.11 ± 0.02 0.09 ± 0.02
P-value 0.05 0.56 0.94 0.42 *0.03 0.05 0.70 0.76 0.82
BMI (kg/m2)
<18.5 11.0 (04) 4.26 ± 1.2 0.08 ± 0.02 0.43 ± 0.1 3.91 ± 0.3 0.11 ± 0.01 0.08 ± 0.02 3.63 ± 0.9 0.10 ± 0.02 0.09 ± 0.00
18.6–25.0 71.0 (27) 6.09 ± 1.3 0.10 ± 0.03 0.44 ± 0.1 3.83 ± 0.7 0.12 ± 0.02 0.10 ± 0.02 3.67 ± 0.7 0.12 ± 0.02 0.09 ± 0.02
≥25.01 18.0 (07) 6.21 ± 1.9 0.10 ± 0.4 0.44 ± 0.1 3.86 ± 0.6 0.12 ± 0.02 0.11 ± 0.02 3.96 ± 0.4 0.11 ± 0.03 0.09 ± 0.03
P-value 0.08 0.69 0.94 0.99 0.37 0.17 0.74 0.47 0.74
Family Income (BDT)
Up to 4000 29.0 (11) 5.06 ± 1.4 0.10 ± 0.03 0.43 ± 0.1 3.88 ± 0.5 0.12 ± 0.02 0.10 ± 0.02 3.72 ± 0.7 0.11 ± 0.02 0.09 ± 0.02
4001–8000 47.0 (18) 5.94 ± 1.5 0.10 ± 0.02 0.44 ± 0.1 3.83 ± 0.8 0.12 ± 0.02 0.10 ± 0.02 3.80 ± 0.7 0.11 ± 0.02 0.09 ± 0.02
≥8001 24.0 (09) 6.22 ± 1.3 0.10 ± 0.04 0.46 ± 0.1 3.85 ± 0.6 0.12 ± 0.02 0.10 ± 0.03 3.56 ± 0.7 0.12 ± 0.03 0.09 ± 0.03
P-value 0.09 0.90 0.73 0.98 0.74 0.92 0.69 0.37 0.96

Maternal characteristics.

Characteristics % (n) Mean ± SD
Maternal age (years) 22.84 ± 4.8
18–20 34.0 (13)
21–25 37.0 (14)
≥26 29.0 (11)
Parity 1.78 ± 0.9
Primiparous 34.0 (13)
Multiparous 66.0 (25)
BMI (kg/m2) 24.65 ± 0.71
<18.5 11.0 (04)
18.6–25.0 71.0 (27)
≥25.01 18.0 (07)
Family income (BDT ) 6131 ± 287
Up to 4000 29.0 (11)
4001–8000 47.0 (18)
≥8001 24.0 (09)
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