<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_jmotherandchild.20202403.2032.d-20-00001_s_007">
<h3>Background</h3>
<p>The study investigated the concentration of IgA, IgM and IgG in colostrum, transitional and mature milk and the effect of parity, age, BMI and family income on secreted immunoglobulin contents of human milk.</p>
</sec>
<sec id="j_jmotherandchild.20202403.2032.d-20-00001_s_008">
<h3>Methods</h3>
<p>Sequential samples of colostrum, transitional and mature milk were collected from 38 women. Enzymelinked immunosorbent assay was used to analyse the immunoglobulin concentrations.</p>
</sec>
<sec id="j_jmotherandchild.20202403.2032.d-20-00001_s_009">
<h3>Results</h3>
<p>The study revealed that IgA was the dominant immunoglobulin and mean concentration in colostrum, transitional and mature milk was 5.92 ± 1.50 g/L, 3.85 ± 0.64 g/L and 3.72 ± 0.68 g/L, respectively. Both IgA and IgM levels of colostrum decreased significantly in both transitional (<italic>P</italic> = 0.000) and mature milk (<italic>P</italic> = 0.000), while the concentration of IgG rises significantly in them (colostrum <italic>vs</italic>. transitional milk, <italic>P</italic> = 0.000; and colostrum <italic>vs</italic>. mature milk <italic>P</italic> = 0.011). While maternal age, BMI and family income had no significant influence on the immunoglobulin levels at different stages of lactation, parity showed significant influence on IgG (<italic>P</italic> = 0.03) and IgM (<italic>P</italic> = 0.05) levels of transitional milk and IgA level of colostrum (<italic>P</italic> = 0.05).</p>
</sec>
<sec id="j_jmotherandchild.20202403.2032.d-20-00001_s_010">
<h3>Conclusion</h3>
<p>The findings suggest that immunoglobulin composition in breast milk is strongly associated with stage of lactation and is likely to be more susceptible to parity than BMI and socioeconomic characteristics.</p>
</sec>
</abstract>

Background
The study investigated the concentration of IgA, IgM and IgG in colostrum, transitional and mature milk and the effect of parity, age, BMI and family income on secreted immunoglobulin contents of human milk.


Methods
Sequential samples of colostrum, transitional and mature milk were collected from 38 women. Enzymelinked immunosorbent assay was used to analyse the immunoglobulin concentrations.


Results
The study revealed that IgA was the dominant immunoglobulin and mean concentration in colostrum, transitional and mature milk was 5.92 ± 1.50 g/L, 3.85 ± 0.64 g/L and 3.72 ± 0.68 g/L, respectively. Both IgA and IgM levels of colostrum decreased significantly in both transitional (P = 0.000) and mature milk (P = 0.000), while the concentration of IgG rises significantly in them (colostrum vs. transitional milk, P = 0.000; and colostrum vs. mature milk P = 0.011). While maternal age, BMI and family income had no significant influence on the immunoglobulin levels at different stages of lactation, parity showed significant influence on IgG (P = 0.03) and IgM (P = 0.05) levels of transitional milk and IgA level of colostrum (P = 0.05).


Conclusion
The findings suggest that immunoglobulin composition in breast milk is strongly associated with stage of lactation and is likely to be more susceptible to parity than BMI and socioeconomic characteristics.

Immunoglobulins content in colostrum, transitional and mature milk of Bangladeshi mothers: Influence of parity and sociodemographic characteristics

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
The study investigated the concentration of IgA, IgM and IgG in colostrum, transitional and mature milk and the effect of parity, age, BMI and...

Immunoglobulins content in colostrum, transitional and mature milk of Bangladeshi mothers: Influence of parity and sociodemographic characteristics

Article Category: Original paper

Published Online: Jan 29, 2021

Page range: 8 - 15

DOI: https://doi.org/10.34763/jmotherandchild.20202403.2032.d-20-00001

Keywords
human, immunoglobulins, milk, parity

© 2020 Hashemi Akhter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Immunoglobulins content in colostrum, transitional and mature milk of Bangladeshi mothers: Influence of parity and sociodemographic characteristics

Article Category: Original paper

Published Online: Jan 29, 2021

Page range: 8 - 15

DOI: https://doi.org/10.34763/jmotherandchild.20202403.2032.d-20-00001

Keywordshuman, immunoglobulins, milk, parity

© 2020 Hashemi Akhter et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
human, immunoglobulins, milk, parity