<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging.</p></abstract>

Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless, most data from the international registers of childhood cancer survivors (CCS) stress that this population of patients is at high risk for late sequelae and their biologica/ aging starts earlier in life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects the intracellular processes leading to the chronic deterioration of organ function and premature senescence. The present review focuses on the late effects of anticancer treatment on various human organs that may lead to premature aging.

Risk factors for premature aging in childhood cancer survivors

Journal of Mother and Child

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Risk factors for premature aging in childhood cancer survivors"}

Over the last decades, the overall survival rate for childhood cancer has increased from 20% to 80%, which is the result of advances in treatment Nevertheless,...

Risk factors for premature aging in childhood cancer survivors

Article Category: Invited review

Published Online: Jul 08, 2019

Page range: 97 - 103

Received: May 28, 2019

Accepted: Jun 10, 2019

DOI: https://doi.org/10.34763/devperiodmed.20192302.97103

© 2019 Maryna Krawczuk-Rybak, Eryk Latoch, published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.