Recent highlights of research on androgen receptors in women

1Azziz R, Sanchez LA, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, Taylor K, Boots LR. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab. 2004;89:453-462.Azziz R Sanchez LA Knochenhauer ES Moran C Lazenby J Stephens KC Taylor K Boots LR Androgen excess in women: experience with over 1000 consecutive patients J Clin Endocrinol Metab 200489453 46210.1210/jc.2003-031122Search in Google Scholar

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8Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C. Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J Endocrinol. 1990;126:17-26.Takeda H Chodak G Mutchnik S Nakamoto T Chang C Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor J Endocrinol 199012617 2610.1677/joe.0.1260017Search in Google Scholar

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10Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol. 2002;20:3001-3015.Gelmann EP Molecular biology of the androgen receptor J Clin Oncol 2002203001 301510.1200/JCO.2002.10.01812089231Search in Google Scholar

11Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001;1:34-45.Feldman BJ Feldman D The development of androgen-independent prostate cancer Nat Rev Cancer 2001134 4510.1038/3509400911900250Search in Google Scholar

12Graham L, Schweizer MT. Targeting persistent androgen receptor signaling in castration-resistant prostate cancer. Med Oncol. 2016;33:44.Graham L Schweizer MT Targeting persistent androgen receptor signaling in castration-resistant prostate cancer Med Oncol 2016334410.1007/s12032-016-0759-327042852Search in Google Scholar

13Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, Chen H, Kong X, Melamed J, Tepper CG, Kung H-J, Brodie AMH, Edwards J, Qiu Y. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res. 2009;69:2305-2313.Guo Z Yang X Sun F Jiang R Linn DE Chen H Chen H Kong X Melamed J Tepper CG Kung H-J Brodie AMH Edwards J Qiu Y A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth Cancer Res 2009692305 231310.1158/0008-5472.CAN-08-3795267282219244107Search in Google Scholar

14Nyquist MD, Dehm SM. Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression. Horm Cancer. 2013;4:61-69.Nyquist MD Dehm SM Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression Horm Cancer 2013461 6910.1007/s12672-013-0131-4395709223307762Search in Google Scholar

15Azoitei A, Merseburger AS, Godau B, Hoda MR, Schmid E, Cronauer MV. C-terminally truncated constitutively active androgen receptor variants and their biologic and clinical significance in castration-resistant prostate cancer. J Steroid Biochem Mol Biol. 2017;166:38-44.Azoitei A Merseburger AS Godau B Hoda MR Schmid E Cronauer MV C-terminally truncated constitutively active androgen receptor variants and their biologic and clinical significance in castration-resistant prostate cancer J Steroid Biochem Mol Biol 201716638 4410.1016/j.jsbmb.2016.06.00827345700Search in Google Scholar

16Sprenger CCT, Plymate SR. The link between androgen receptor splice variants and castration-resistant prostate cancer. Horm Cancer. 2014;5:207-217.Sprenger CCT Plymate SR The link between androgen receptor splice variants and castration-resistant prostate cancer Horm Cancer 20145207 21710.1007/s12672-014-0177-y430803524798453Search in Google Scholar

17Xu J, Qiu Y. Role of androgen receptor splice variants in prostate cancer metastasis. Asian J Urol. 2016;3:177-184.Xu J Qiu Y Role of androgen receptor splice variants in prostate cancer metastasis Asian J Urol 20163177 18410.1016/j.ajur.2016.08.003532517928239558Search in Google Scholar

18Xu D, Zhan Y, Qi Y, Cao B, Bai S, Xu W, Gambhir SS, Lee P, Sartor O, Flemington EK, Zhang H, Hu C-D, Dong Y. Androgen receptor splice variants dimerize to transactivate target genes. Cancer Res. 2015;75:3663-3671.Xu D Zhan Y Qi Y Cao B Bai S Xu W Gambhir SS Lee P Sartor O Flemington EK Zhang H Hu C-D Dong Y Androgen receptor splice variants dimerize to transactivate target genes Cancer Res 2015753663 367110.1158/0008-5472.CAN-15-0381455837626060018Search in Google Scholar

19McCrea E, Sissung TM, Price DK, Chau CH, Figg WD. Androgen receptor variation affects prostate cancer progression and drug resistance. Pharmacol Res. 2016;114:152-162.McCrea E Sissung TM Price DK Chau CH Figg WD Androgen receptor variation affects prostate cancer progression and drug resistance Pharmacol Res 2016114152 16210.1016/j.phrs.2016.10.001515481127725309Search in Google Scholar

20Welti J, Rodrigues DN, Sharp A, Sun S, Lorente D, Riisnaes R, Figueiredo I, Zafeiriou Z, Rescigno P, de Bono JS, Plymate SR. Analytical validation and clinical qualification of a new immunohistochemical assay for androgen receptor splice variant-7 protein expression in metastatic castration-resistant prostate cancer. Eur Urol. 2016;70:599-608.Welti J Rodrigues DN Sharp A Sun S Lorente D Riisnaes R Figueiredo I Zafeiriou Z Rescigno P de Bono JS Plymate SR. Analytical validation and clinical qualification of a new immunohistochemical assay for androgen receptor splice variant-7 protein expression in metastatic castration-resistant prostate cancer Eur Urol 201670599 60810.1016/j.eururo.2016.03.049501557527117751Search in Google Scholar

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22Hörnberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, Bergh A, Wikström P. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS ONE. 2011;6:e19059.Hörnberg E Ylitalo EB Crnalic S Antti H Stattin P Widmark A Bergh A Wikström P. Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival PLoS ONE 20116e1905910.1371/journal.pone.0019059Search in Google Scholar

23Guo H, Li Y, Luo M, Lin S, Chen J, Ma Q, Gu Y, Jiang Z, Gui Y. Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells. Mol Reprod Dev. 2015;82:976-985.Guo H Li Y Luo M Lin S Chen J Ma Q Gu Y Jiang Z Gui Y Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells Mol Reprod Dev 201582976 98510.1002/mrd.22576Search in Google Scholar

24Kimura N, Mizokami A, Oonuma T, Sasano H, Nagura H. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. J Histochem Cytochem. 1993;1;41:671-678.Kimura N Mizokami A Oonuma T Sasano H Nagura H Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues J Histochem Cytochem 1993141671 67810.1177/41.5.8468448Search in Google Scholar

25Hodgins MB, Spike RC, Mackie RM, MacLean AB. An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina. Br J Obstet Gynaecol. 1998;105:216-222.Hodgins MB Spike RC Mackie RM MacLean AB An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina Br J Obstet Gynaecol 1998105216 22210.1111/j.1471-0528.1998.tb10056.xSearch in Google Scholar

26Kohlberger PD, Joura EA, Bancher D, Gitsch G, Breitenecker G, Kieback DG. Evidence of androgen receptor expression in lichen sclerosus: an immunohistochemical study. J Soc Gynecol Investig. 1998;5:331-333.Kohlberger PD Joura EA Bancher D Gitsch G Breitenecker G Kieback DG Evidence of androgen receptor expression in lichen sclerosus: an immunohistochemical study J Soc Gynecol Investig 19985331 33310.1016/S1071-5576(98)00033-1Search in Google Scholar

27Hu DG, Hickey TE, Irvine C, Wijayakumara DD, Lu L, Tilley WD, Selth LA, Mackenzie PI. Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues. Horm Cancer. 2014;5:61-71.Hu DG Hickey TE Irvine C Wijayakumara DD Lu L Tilley WD Selth LA Mackenzie PI Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues Horm Cancer 2014561 7110.1007/s12672-014-0171-424570075Search in Google Scholar

28Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;21:1440-1447.Ferriman D Gallwey JD Clinical assessment of body hair growth in women J Clin Endocrinol Metab 1961211440 144710.1210/jcem-21-11-144013892577Search in Google Scholar

29Rachoń D. Differential diagnosis of hyperandrogenism in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2012;120:205-209.Rachoń D. Differential diagnosis of hyperandrogenism in women with polycystic ovary syndrome Exp Clin Endocrinol Diabetes 2012120205 20910.1055/s-0031-129976522421986Search in Google Scholar

30Stanczyk FZ. Diagnosis of hyperandrogenism: Biochemical criteria. Best Pract Res Clin Endocrinol Metab. 2006;20:177-191.Stanczyk FZ Diagnosis of hyperandrogenism: Biochemical criteria Best Pract Res Clin Endocrinol Metab 200620177 19110.1016/j.beem.2006.03.00716772150Search in Google Scholar

31Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91:456-488.Azziz R Carmina E Dewailly D Diamanti-Kandarakis E Escobar-Morreale HF Futterweit W Janssen OE Legro RS Norman RJ Taylor AE Witchel SF The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report Fertil Steril 200991456 48810.1016/j.fertnstert.2008.06.03518950759Search in Google Scholar

32Apparao KB, Lovely LP, Gui Y, Lininger RA, Lessey BA. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biol Reprod. 2002;66:297-304.Apparao KB Lovely LP Gui Y Lininger RA Lessey BA Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome Biol Reprod 200266297 30410.1095/biolreprod66.2.29711804942Search in Google Scholar

33Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H, Mesquita D, Bueno HB, Chang-Claude J, Clavel-Chapelon F, Fournier A, Gils V, H C, Gonzalez CA, Gurrea AB, Critselis E, Khaw KT, Krogh V, Lahmann PH, Nagel G, Olsen A, Onland-Moret NC, Overvad K, Palli D, Panico S, Peeters P, Quirós JR, Roddam A, Thiebaut A, Tjønneland A, Chirlaque MD, Trichopoulou A, Trichopoulos D, Tumino R, Vineis P, Norat T, Ferrari P, Slimani N, Riboli E. Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer Inst. 2005;97:755-765.Kaaks R Berrino F Key T Rinaldi S Dossus L Biessy C Secreto G Amiano P Bingham S Boeing H Mesquita D Bueno HB Chang-Claude J Clavel-Chapelon F Fournier A Gils V H C Gonzalez CA Gurrea AB Critselis E Khaw KT Krogh V Lahmann PH Nagel G Olsen A Onland-Moret NC Overvad K Palli D Panico S Peeters P Quirós JR Roddam A Thiebaut A Tjønneland A Chirlaque MD Trichopoulou A Trichopoulos D Tumino R Vineis P Norat T Ferrari P Slimani N Riboli E. Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC) J Natl Cancer Inst 200597755 76510.1093/jnci/dji13215900045Search in Google Scholar

34Chia K, O’Brien M, Brown M, Lim E. Targeting the androgen receptor in breast cancer. Curr Oncol Rep. 2015;17:4.Chia K O’Brien M Brown M Lim E Targeting the androgen receptor in breast cancer Curr Oncol Rep 201517410.1007/s11912-014-0427-825665553Search in Google Scholar

35Iacopetta D, Rechoum Y, Fuqua SA. The role of androgen receptor in breast cancer. Drug Discov Today Dis Mech. 2012;9:e19-27.Iacopetta D Rechoum Y Fuqua SA The role of androgen receptor in breast cancer Drug Discov Today Dis Mech 20129e19 2710.1016/j.ddmec.2012.11.003464327926568765Search in Google Scholar

36Mishra AK, Agrawal U, Negi S, Bansal A, Mohil R, Chintamani C, Bhatnagar A, Bhatnagar D, Saxena S. Expression of androgen receptor in breast cancer & its correlation with other steroid receptors & growth factors. Indian J Med Res. 2012;135:843-852.Mishra AK Agrawal U Negi S Bansal A Mohil R Chintamani C Bhatnagar A Bhatnagar D Saxena S Expression of androgen receptor in breast cancer & its correlation with other steroid receptors & growth factors Indian J Med Res 2012135843 852Search in Google Scholar

37Rampurwala M, Wisinski KB, O’Regan R. Role of the androgen receptor in triple-negative breast cancer. Clin Adv Hematol Oncol. 2016;14:186-193.Rampurwala M Wisinski KB O’Regan R. Role of the androgen receptor in triple-negative breast cancer Clin Adv Hematol Oncol 201614186 193Search in Google Scholar

38Wang F, Pan J, Liu Y, Meng Q, Lv P, Qu F, Ding G-L, Klausen C, Leung PCK, Chan HC, Yao W, Zhou C-Y, Shi B, Zhang J, Sheng J, Huang H. Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proc Natl Acad Sci US A. 2015;112:4743-4748.Wang F Pan J Liu Y Meng Q Lv P Qu F Ding G-L Klausen C Leung PCK Chan HC Yao W Zhou C-Y Shi B Zhang J Sheng J Huang H Alternative splicing of the androgen receptor in polycystic ovary syndrome Proc Natl Acad Sci US A 20151124743 474810.1073/pnas.1418216112440315725825716Search in Google Scholar

39Walters KA, Handelsman DJ. Androgen receptor splice variants and polycystic ovary syndrome: cause or effect? Asian J Androl 2016;18:442-443.Walters KA Handelsman DJ Androgen receptor splice variants and polycystic ovary syndrome: cause or effect? Asian J Androl 201618442 44310.4103/1008-682X.161600485410026306851Search in Google Scholar