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Oral Microbiota and Pharyngeal-Laryngeal Cancer Risk: Evidence from Mendelian Randomization in East Asian Populations

JINGFENG FU

JINGFENG FU

  • School of Pharmacy and Medical Technology, Putian UniversityPutian, China
  • Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine, Putian UniversityPutian, China
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FU, JINGFENG
  
Sep 16, 2025
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Article Category: Original Paper
Published Online: Sep 16, 2025
Page range: 338 - 346
Received: Jun 30, 2025
Accepted: Aug 05, 2025
DOI: https://doi.org/10.33073/pjm-2025-029
Keywords
© 2025 JINGFENG FU, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig.1.

Schematic representation of the MR analysis.
Schematic representation of the MR analysis.

Fig. 2.

IVW MR analysis of the causal association between oral microbiota and PLC.
IVW MR analysis of the causal association between oral microbiota and PLC.

Fig. 3.

Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (risk factors).
Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (risk factors).

Fig. 4.

Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (protective factors).
Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (protective factors).

Sensitivity analysis results of the MR study for PLC_

Exposure Heterogeneity analysis Pleiotropy analysis
Inverse variance weighted MR Egger MR Egger MR PRESSO global test
Q Q_df Q_pval Q Q_df Q_pval Egger_ intercept se pval pval
g__TM7x 14.15 15.00 0.51 14.11 14.00 0.44 –0.20 1.01 0.84 0.50
g__Streptococcus-1 13.55 14.00 0.48 13.54 13.00 0.41 0.05 0.58 0.93 0.56
s__Fusobacterium_periodonticum-1 12.79 21.00 0.92 12.27 20.00 0.91 –0.62 0.86 0.48 0.93
s__Streptococcus_gordonii 17.85 14.00 0.21 17.36 13.00 0.18 –1.19 1.97 0.56 0.29
s__Streptococcus-2 11.94 17.00 0.80 11.65 16.00 0.77 –0.41 0.78 0.60 0.83
g__Solobacterium 14.12 15.00 0.52 14.05 14.00 0.45 –0.22 0.83 0.80 0.56
s__Capnocytophaga_sputigena 8.40 16.00 0.94 8.40 15.00 0.91 –0.04 1.27 0.97 0.96
s__Fusobacterium_periodonticum-2 15.97 20.00 0.72 15.93 19.00 0.66 0.19 0.95 0.85 0.75
s__Streptococcus-3 17.36 20.00 0.63 16.08 19.00 0.65 1.51 1.34 0.27 0.65
s__Haemophilus 8.52 13.00 0.81 7.46 12.00 0.83 0.60 0.58 0.32 0.83
g__Campylobacter 18.33 16.00 0.30 15.32 15.00 0.43 0.76 0.44 0.11 0.36
f__Saccharimonadaceae-1 14.54 16.00 0.56 12.20 15.00 0.66 1.30 0.85 0.15 0.53
f__Saccharimonadaceae-2 31.32 22.00 0.09 31.32 21.00 0.07 –0.01 0.98 0.99 0.10
f__Saccharimonadaceae-3 8.71 15.00 0.89 8.53 14.00 0.86 0.56 1.32 0.68 0.93
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Life Sciences, Microbiology and Virology
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