Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Nuclear Medicine, The Affiliated Hospital of Yunnan UniversityKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Transfusion Medicine, The Affiliated Hospital of Yunnan UniversityKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University; Yunnan Key Laboratory of Laboratory Medicine; Yunnan Province Clinical Research Center for Laboratory MedicineKunming, China
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Abdul Momin MHF, Liakopoulos A, Phee LM, Wareham DW. Emergence and nosocomial spread of carbapenem-resistant OXA-232-producing Klebsiella pneumoniae in Brunei Darussalam. J Glob Antimicrob Resist. 2017 Jun;9:96–99. https://doi.org/10.1016/j.jgar.2017.02.008Abdul MominMHFLiakopoulosAPheeLMWarehamDW.Emergence and nosocomial spread of carbapenem-resistant OXA-232-producing Klebsiella pneumoniae in Brunei Darussalam. J Glob Antimicrob Resist. 2017Jun;9:96–99. https://doi.org/10.1016/j.jgar.2017.02.008Search in Google Scholar
Aslan AT, Kırbaş E, Sancak B, Tanrıverdi ES, Otlu B, Gürsoy NC, Yılmaz YA, Tozluyurt A, Liste Ü, Bıçakcıgil A, et al; Study Group for Carbapenem Resistance (SCARE). A retrospective observational cohort study of the clinical epidemiology of bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae in an OXA-48 endemic setting. Int J Antimicrob Agents. 2022 Apr; 59(4):106554. https://doi.org/10.1016/j.ijantimicag.2022.106554AslanATKırbaşESancakBTanrıverdiESOtluBGürsoyNCYılmazYATozluyurtAListeÜBıçakcıgilAStudy Group for Carbapenem Resistance (SCARE). A retrospective observational cohort study of the clinical epidemiology of bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae in an OXA-48 endemic setting. Int J Antimicrob Agents. 2022Apr; 59(4):106554. https://doi.org/10.1016/j.ijantimicag.2022.106554Search in Google Scholar
Bachman MA, Lenio S, Schmidt L, Oyler JE, Weiser JN. Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia. mBio. 2012 Nov;3(6):e00224-11. https://doi.org/10.1128/mBio.00224-11BachmanMALenioSSchmidtLOylerJEWeiserJN.Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia. mBio. 2012Nov;3(6):e00224-11. https://doi.org/10.1128/mBio.00224-11Search in Google Scholar
Bachman MA, Miller VL, Weiser JN. Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin. PLoS Pathog. 2009 Oct;5(10):e1000622. https://doi.org/10.1371/journal.ppat.1000622BachmanMAMillerVLWeiserJN.Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin. PLoS Pathog. 2009Oct;5(10):e1000622. https://doi.org/10.1371/journal.ppat.1000622Search in Google Scholar
Boyd SE, Holmes A, Peck R, Livermore DM, Hope W. OXA-48-like β-lactamases: Global epidemiology, treatment options, and development pipeline. Antimicrob Agents Chemother. 2022 Aug; 66(8):e0021622. https://doi.org/10.1128/aac.00216-22BoydSEHolmesAPeckRLivermoreDMHopeW.OXA-48-like β-lactamases: Global epidemiology, treatment options, and development pipeline. Antimicrob Agents Chemother. 2022Aug; 66(8):e0021622. https://doi.org/10.1128/aac.00216-22Search in Google Scholar
Cerón S, Salem-Bango Z, Contreras DA, Ranson EL, Yang S. Clinical and genomic characterization of carbapenem-resistant Klebsiella pneumoniae with concurrent production of NDM and OXA-48-like carbapenemases in Southern California, 2016–2022. Microorganisms. 2023 Jun;11(7):1717. https://doi.org/10.3390/microorganisms11071717CerónSSalem-BangoZContrerasDARansonELYangS.Clinical and genomic characterization of carbapenem-resistant Klebsiella pneumoniae with concurrent production of NDM and OXA-48-like carbapenemases in Southern California, 2016–2022. Microorganisms. 2023Jun;11(7):1717. https://doi.org/10.3390/microorganisms11071717Search in Google Scholar
Chen T, Xu H, Chen Y, Ji J, Ying C, Liu Z, Xu H, Zhou K, Xiao Y, Shen P. Identification and characterization of OXA-232-producing sequence Type 231 multidrug resistant Klebsiella pneumoniae strains causing bloodstream infections in China. Microbiol Spectr. 2023 Mar;11(2):e0260722. https://doi.org/10.1128/spectrum.02607-22ChenTXuHChenYJiJYingCLiuZXuHZhouKXiaoYShenP.Identification and characterization of OXA-232-producing sequence Type 231 multidrug resistant Klebsiella pneumoniae strains causing bloodstream infections in China. Microbiol Spectr. 2023Mar;11(2):e0260722. https://doi.org/10.1128/spectrum.02607-22Search in Google Scholar
Chen Y, Fang L, Yang Y, Yan R, Fu Y, Shen P, Zhao D, Chen Y, Hua X, Jiang Y, et al. Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring blaOXA-48-like genes in China. J Med Microbiol. 2021 Mar;70(3):001306. https://doi.org/10.1099/jmm.0.001306ChenYFangLYangYYanRFuYShenPZhaoDChenYHuaXJiangYEmergence of carbapenem-resistant Klebsiella pneumoniae harbouring blaOXA-48-like genes in China. J Med Microbiol. 2021Mar;70(3):001306. https://doi.org/10.1099/jmm.0.001306Search in Google Scholar
Holt KE, Wertheim H, Zadoks RN, Baker S, Whitehouse CA, Dance D, Jenney A, Connor TR, Hsu LY, Severin J, et al. Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci USA. 2015 Jul;112(27):E3574-E3581. https://doi.org/10.1073/pnas.1501049112HoltKEWertheimHZadoksRNBakerSWhitehouseCADanceDJenneyAConnorTRHsuLYSeverinJGenomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc Natl Acad Sci USA. 2015Jul;112(27):E3574-E3581. https://doi.org/10.1073/pnas.1501049112Search in Google Scholar
Idriss HT, Naismith JH. TNFα and the TNF receptor superfamily: Structure-function relationship(s). Microsc Res Tech. 2000 Aug; 50(3):184–195. https://doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-HIdrissHTNaismithJH.TNFα and the TNF receptor superfamily: Structure-function relationship(s). Microsc Res Tech. 2000Aug; 50(3):184–195. https://doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-HSearch in Google Scholar
Lan P, Jiang Y, Zhou J, Yu Y. A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae. J Glob Antimicrob Resist. 2021 Jun;25:26–34. https://doi.org/10.1016/j.jgar.2021.02.020LanPJiangYZhouJYuY.A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae. J Glob Antimicrob Resist. 2021Jun;25:26–34. https://doi.org/10.1016/j.jgar.2021.02.020Search in Google Scholar
Lee BE, Seol HY, Kim TK, Seong EY, Song SH, Lee DW, Lee SB, Kwak IS. Recent clinical overview of renal and perirenal abscesses in 56 consecutive cases. Korean J Intern Med. 2008 Sep;23(3):140–148. https://doi.org/10.3904/kjim.2008.23.3.140LeeBESeolHYKimTKSeongEYSongSHLeeDWLeeSBKwakIS.Recent clinical overview of renal and perirenal abscesses in 56 consecutive cases. Korean J Intern Med. 2008Sep;23(3):140–148. https://doi.org/10.3904/kjim.2008.23.3.140Search in Google Scholar
Lutgring JD, Zhu W, de Man TJB, Avillan JJ, Anderson KF, Lonsway DR, Rowe LA, Batra D, Rasheed JK, Limbago BM. Phenotypic and Genotypic characterization of Enterobacteriaceae producing oxacillinase-48-like carbapenemases, United States. Emerg Infect Dis. 2018 Apr;24(4):700–709. https://doi.org/10.3201/eid2404.171377LutgringJDZhuWde ManTJBAvillanJJAndersonKFLonswayDRRoweLABatraDRasheedJKLimbagoBM.Phenotypic and Genotypic characterization of Enterobacteriaceae producing oxacillinase-48-like carbapenemases United States. Emerg Infect Dis. 2018Apr;24(4):700–709. https://doi.org/10.3201/eid2404.171377Search in Google Scholar
Mancini S, Poirel L, Tritten ML, Lienhard R, Bassi C, Nordmann P. Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland. J Antimicrob Chemother. 2018 Mar;73(3):821–823. https://doi.org/10.1093/jac/dkx428ManciniSPoirelLTrittenMLLienhardRBassiCNordmannP.Emergence of an MDR Klebsiella pneumoniae ST231 producing OXA-232 and RmtF in Switzerland. J Antimicrob Chemother. 2018Mar;73(3):821–823. https://doi.org/10.1093/jac/dkx428Search in Google Scholar
Mehrotra T, Konar D, Pragasam AK, Kumar S, Jana P, Babele P, Paul D, Purohit A, Tanwar S, Bakshi S, et al. Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci USA. 2023 Aug;120(33):e2305465120. https://doi.org/10.1073/pnas.2305465120MehrotraTKonarDPragasamAKKumarSJanaPBabelePPaulDPurohitATanwarSBakshiSAntimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis. Proc Natl Acad Sci USA. 2023Aug;120(33):e2305465120. https://doi.org/10.1073/pnas.2305465120Search in Google Scholar
Poirel L, Héritier C, Tolün V, Nordmann P. Emergence of oxacil-linase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004 Jan;48(1):15–22. https://doi.org/10.1128/aac.48.1.15-22.2004PoirelLHéritierCTolünVNordmannP.Emergence of oxacil-linase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004Jan;48(1):15–22. https://doi.org/10.1128/aac.48.1.15-22.2004Search in Google Scholar
Potron A, Rondinaud E, Poirel L, Belmonte O, Boyer S, Camiade S, Nordmann P. Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Entero-bacteriaceae. Int J Antimicrob Agents. 2013 Apr;41(4):325–329. https://doi.org/10.1016/j.ijantimicag.2012.11.007PotronARondinaudEPoirelLBelmonteOBoyerSCamiadeSNordmannP.Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Entero-bacteriaceae. Int J Antimicrob Agents. 2013Apr;41(4):325–329. https://doi.org/10.1016/j.ijantimicag.2012.11.007Search in Google Scholar
Qian C, Zhang S, Xu M, Zeng W, Chen L, Zhao Y, Zhou C, Zhang Y, Cao J, Zhou T. Genetic and phenotypic characterization of multidrug-resistant Klebsiella pneumoniae from liver abscess. Microbiol Spectr. 2023 Feb;11(1):e0224022. https://doi.org/10.1128/spectrum.02240-22QianCZhangSXuMZengWChenLZhaoYZhouCZhangYCaoJZhouT.Genetic and phenotypic characterization of multidrug-resistant Klebsiella pneumoniae from liver abscess. Microbiol Spectr. 2023Feb;11(1):e0224022. https://doi.org/10.1128/spectrum.02240-22Search in Google Scholar
Shankar C, Basu S, Lal B, Shanmugam S, Vasudevan K, Mathur P, Ramaiah S, Anbarasu A, Veeraraghavan B. Aerobactin seems to be a promising marker compared with unstable RmpA2 for the identification of hypervirulent carbapenem-resistant Klebsiella pneumoniae: In silico and in vitro evidence. Front Cell Infect Microbiol. 2021 Sep; 11:709681. https://doi.org/10.3389/fcimb.2021.709681ShankarCBasuSLalBShanmugamSVasudevanKMathurPRamaiahSAnbarasuAVeeraraghavanB.Aerobactin seems to be a promising marker compared with unstable RmpA2 for the identification of hypervirulent carbapenem-resistant Klebsiella pneumoniae: In silico and in vitro evidence. Front Cell Infect Microbiol. 2021Sep; 11:709681. https://doi.org/10.3389/fcimb.2021.709681Search in Google Scholar
Shankar C, Mathur P, Venkatesan M, Pragasam AK, Anandan S, Khurana S, Veeraraghavan B. Rapidly disseminating blaOXA-232 carrying Klebsiella pneumoniae belonging to ST231 in India: Multiple and varied mobile genetic elements. BMC Microbiol. 2019 Jun; 19(1):137. https://doi.org/10.1186/s12866-019-1513-8ShankarCMathurPVenkatesanMPragasamAKAnandanSKhuranaSVeeraraghavanB.Rapidly disseminating blaOXA-232 carrying Klebsiella pneumoniae belonging to ST231 in India: Multiple and varied mobile genetic elements. BMC Microbiol. 2019Jun; 19(1):137. https://doi.org/10.1186/s12866-019-1513-8Search in Google Scholar
Shen S, Han R, Yin D, Jiang B, Ding L, Guo Y, Wu S, Wang C, Zhang H, Hu F. A nationwide genomic study of clinical Klebsiella pneumoniae carrying blaOXA-232 and rmtF in China. Microbiol Spectr. 2023 Jun;11(3):e0386322. https://doi.org/10.1128/spectrum.03863-22ShenSHanRYinDJiangBDingLGuoYWuSWangCZhangHHuF.A nationwide genomic study of clinical Klebsiella pneumoniae carrying blaOXA-232 and rmtF in China. Microbiol Spectr. 2023Jun;11(3):e0386322. https://doi.org/10.1128/spectrum.03863-22Search in Google Scholar
Singh S, Anshita D, Ravichandiran V. MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021 Dec; 101(Pt_B):107598. https://doi.org/10.1016/j.intimp.2021.107598SinghSAnshitaDRavichandiranV.MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021Dec; 101(Pt_B):107598. https://doi.org/10.1016/j.intimp.2021.107598Search in Google Scholar
Singh S, Pathak A, Fatima N, Sahu C, Prasad KN. Characterisation of OXA-48-like carbapenemases in Escherichia coli and Klebsiella pneumoniae from North India. 3 Biotech. 2023 May;13(5):134. https://doi.org/10.1007/s13205-023-03537-8SinghSPathakAFatimaNSahuCPrasadKN.Characterisation of OXA-48-like carbapenemases in Escherichia coli and Klebsiella pneumoniae from North India. 3 Biotech. 2023May;13(5):134. https://doi.org/10.1007/s13205-023-03537-8Search in Google Scholar
Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014 Sep;6(10): a016295. https://doi.org/10.1101/cshperspect.a016295TanakaTNarazakiMKishimotoT.IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014Sep;6(10): a016295. https://doi.org/10.1101/cshperspect.a016295Search in Google Scholar
Wu Y, Jiang T, He X, Shao J, Wu C, Mao W, Jia H, He F, Kong Y, Wu J, et al. Global phylogeography and genomic epidemiology of carbapenem-resistant blaOXA-232-carrying Klebsiella pneumoniae sequence type 15 lineage. Emerg Infect Dis. 2023 Nov;29(11):2246– 2256. https://doi.org/10.3201/eid2911.230463WuYJiangTHeXShaoJWuCMaoWJiaHHeFKongYWuJGlobal phylogeography and genomic epidemiology of carbapenem-resistant blaOXA-232-carrying Klebsiella pneumoniae sequence type 15 lineage. Emerg Infect Dis. 2023Nov;29(11):2246–2256. https://doi.org/10.3201/eid2911.230463Search in Google Scholar
Wyres KL, Nguyen TNT, Lam MMC, Judd LM, van Vinh Chau N, Dance DAB, Ip M, Karkey A, Ling CL, Miliya T, et al. Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia. Genome Med. 2020 Jan;12(1):11. https://doi.org/10.1186/s13073-019-0706-yWyresKLNguyenTNTLamMMCJuddLMvan Vinh ChauNDanceDABIpMKarkeyALingCLMiliyaTGenomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia. Genome Med. 2020Jan;12(1):11. https://doi.org/10.1186/s13073-019-0706-ySearch in Google Scholar