<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. <italic>Lactobacillus</italic> spp. is the most common bacteria within the reproductive tract. However, the protective role of <italic>Lactobacilli</italic> in the vagina has been well described in the literature, while it is still unknown what function <italic>Lactobacilli</italic> may have in the uterus. Moreover, new research shows that <italic>Lactobacillus</italic> spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-<italic>Lactobacillus</italic> spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of <italic>Lactobacillus</italic> spp. in miscarriage.</p></abstract>

Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. Lactobacillus spp. is the most common bacteria within the reproductive tract. However, the protective role of Lactobacilli in the vagina has been well described in the literature, while it is still unknown what function Lactobacilli may have in the uterus. Moreover, new research shows that Lactobacillus spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-Lactobacillus spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of Lactobacillus spp. in miscarriage.

Can <italic>Lactobacillus</italic> spp. Be a Factor Reducing the Risk of Miscarriage?

Polish Journal of Microbiology

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Can  spp. Be a Factor Reducing the Risk of Miscarriage?

Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and...

Can Lactobacillus spp. Be a Factor Reducing the Risk of Miscarriage?

Article Category: mini-review

Published Online: Dec 06, 2021

Page range: 431 - 446

Received: Sep 17, 2021

Accepted: Oct 30, 2021

DOI: https://doi.org/10.33073/pjm-2021-043

Keywords
miscarriage, pregnancy, uterine microbiota, vaginal microbiota

© 2021 Monika Stasiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Can Lactobacillus spp. Be a Factor Reducing the Risk of Miscarriage?

Article Category: mini-review

Published Online: Dec 06, 2021

Page range: 431 - 446

Received: Sep 17, 2021

Accepted: Oct 30, 2021

DOI: https://doi.org/10.33073/pjm-2021-043

Keywordsmiscarriage, pregnancy, uterine microbiota, vaginal microbiota

© 2021 Monika Stasiak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
miscarriage, pregnancy, uterine microbiota, vaginal microbiota