<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of important pathogens in a general hospital in Zhengzhou, China from 2011 to 2016, to control antimicrobial-resistant bacteria in hospital and provide support to clinicians and decision-making departments.</p><p>Five dominant bacteria were enrolled based on the data from the general hospital during 6 years. The results of antimicrobial susceptibility testing were interpreted according to Clinical and Laboratory Standards Institute (CLSI). From 2011 to 2016, a total of 19,260 strains of bacteria were isolated, of which <italic>Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa</italic> and <italic>Acinetobacter baumannii</italic> accounted for 51.98%. The resistance rate of <italic>K. pneumoniae</italic> and <italic>E. coli</italic> to carbapenem was less than 15%, but resistance of <italic>K. pneumoniae</italic> to carbapenems increased with time and resistance of <italic>E. coli</italic> to meropenem increased. The rate of extended-spectrum beta-lactamase (ESBL) production among <italic>K. pneumoniae</italic> and <italic>E. coli</italic> was decreasing. For most antibiotics, the resistance rate of ESBL-positive isolates was higher than that of ESBL-negative isolates, excluding carbapenems and cefoxitin. For <italic>S. aureus</italic>, the rate of methicillin-resistant <italic>S. aureus</italic> (MRSA) was stable. Resistance of <italic>S. aureus</italic> to mostly antibiotics decreased with time. Besides polymyxin B, <italic>P. aeruginosa</italic> and <italic>A. baumannii</italic> showed high resistance to other antibiotics. For <italic>A. baumannii</italic>, the resistance rate to mostly antibiotics was increasing. The bacteria showed high levels of resistance and multiple drug resistance. Continuous surveillance and optimizing the use of antibiotics are essential.</p></abstract>

Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of important pathogens in a general hospital in Zhengzhou, China from 2011 to 2016, to control antimicrobial-resistant bacteria in hospital and provide support to clinicians and decision-making departments.Five dominant bacteria were enrolled based on the data from the general hospital during 6 years. The results of antimicrobial susceptibility testing were interpreted according to Clinical and Laboratory Standards Institute (CLSI). From 2011 to 2016, a total of 19,260 strains of bacteria were isolated, of which Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii accounted for 51.98%. The resistance rate of K. pneumoniae and E. coli to carbapenem was less than 15%, but resistance of K. pneumoniae to carbapenems increased with time and resistance of E. coli to meropenem increased. The rate of extended-spectrum beta-lactamase (ESBL) production among K. pneumoniae and E. coli was decreasing. For most antibiotics, the resistance rate of ESBL-positive isolates was higher than that of ESBL-negative isolates, excluding carbapenems and cefoxitin. For S. aureus, the rate of methicillin-resistant S. aureus (MRSA) was stable. Resistance of S. aureus to mostly antibiotics decreased with time. Besides polymyxin B, P. aeruginosa and A. baumannii showed high resistance to other antibiotics. For A. baumannii, the resistance rate to mostly antibiotics was increasing. The bacteria showed high levels of resistance and multiple drug resistance. Continuous surveillance and optimizing the use of antibiotics are essential.

Patterns of Drug-Resistant Bacteria in a General Hospital, China, 2011–2016

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Patterns of Drug-Resistant Bacteria in a General Hospital, China, 2011\u20132016"}

Drug-resistant bacteria has been a threat to public life and property. We described the trends and changes in antibiotic resistance of important pathogens in a...

Patterns of Drug-Resistant Bacteria in a General Hospital, China, 2011–2016

Article Category: original-paper

Published Online: Jun 28, 2019

Page range: 225 - 232

Received: Nov 28, 2018

Accepted: Mar 06, 2019

DOI: https://doi.org/10.33073/pjm-2019-024

Keywords
antimicrobial resistance, Gram-negative bacteria, ESBL, MRSA, surveillance

© 2019 Tingting Mao et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Supplementary Material Details

Patterns of Drug-Resistant Bacteria in a General Hospital, China, 2011–2016

Article Category: original-paper

Published Online: Jun 28, 2019

Page range: 225 - 232

Received: Nov 28, 2018

Accepted: Mar 06, 2019

DOI: https://doi.org/10.33073/pjm-2019-024

Keywordsantimicrobial resistance, Gram-negative bacteria, ESBL, MRSA, surveillance

© 2019 Tingting Mao et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Supplementary Material Details

Keywords
antimicrobial resistance, Gram-negative bacteria, ESBL, MRSA, surveillance