<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Recently, the most significant studies in the field of angiogenesis are related to trials concerning the evaluation of the prognostic significance of endothelial markers. By using an estimation of the expression of endothelial cell markers, immunohistochemical studies can assess for the continuity of the vascular intima, as well as allow for the distinction of early, late and mature forms of endothelial cells. The determination of the endothelial cell phenotype using markers such as CD34, CD31, CD133, e-NOS and von Willebrand factor may provide a valuable tool for the monitoring of both normal physiology as well as neoplastic diseases.</p></abstract>

Recently, the most significant studies in the field of angiogenesis are related to trials concerning the evaluation of the prognostic significance of endothelial markers. By using an estimation of the expression of endothelial cell markers, immunohistochemical studies can assess for the continuity of the vascular intima, as well as allow for the distinction of early, late and mature forms of endothelial cells. The determination of the endothelial cell phenotype using markers such as CD34, CD31, CD133, e-NOS and von Willebrand factor may provide a valuable tool for the monitoring of both normal physiology as well as neoplastic diseases.

The Contribution of Endothelial Marker Proteins in the Determination of Vascular Angiogenic Potential, in Normal Physiological Conditions and in Neoplasia

Department of Histology and Embryology, University of Medical Sciences, Poznan, Poland

Regional Specialized Hospital in Wroclaw, Research and Development Center, Wroclaw, Poland

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Recently, the most significant studies in the field of angiogenesis are related to trials concerning the evaluation of the prognostic significance of...

The Contribution of Endothelial Marker Proteins in the Determination of Vascular Angiogenic Potential, in Normal Physiological Conditions and in Neoplasia

Published Online: Oct 15, 2014

Page range: 69 - 83

DOI: https://doi.org/10.2478/v10052-011-0005-2

Keywords
endothelium, angiogenesis, progenitor cells, endothelial markers (CD31, CD34, CD133, endothelial Nitric Oxide Synthase, von Willebrand factor)

© by Aneta Konwerska

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Contribution of Endothelial Marker Proteins in the Determination of Vascular Angiogenic Potential, in Normal Physiological Conditions and in Neoplasia

Published Online: Oct 15, 2014

Page range: 69 - 83

DOI: https://doi.org/10.2478/v10052-011-0005-2

Keywordsendothelium, angiogenesis, progenitor cells, endothelial markers (CD31, CD34, CD133, endothelial Nitric Oxide Synthase, von Willebrand factor)

© by Aneta Konwerska

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
endothelium, angiogenesis, progenitor cells, endothelial markers (CD31, CD34, CD133, endothelial Nitric Oxide Synthase, von Willebrand factor)