1. bookVolume 10 (2010): Issue 6 (December 2010)
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Format
Journal
eISSN
1335-8871
First Published
07 Mar 2008
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6 times per year
Languages
English
access type Open Access

Model Based Determination of Detection Limits for Proton Transfer Reaction Mass Spectrometer

Published Online: 20 Jan 2011
Volume & Issue: Volume 10 (2010) - Issue 6 (December 2010)
Page range: 180 - 188
Journal Details
License
Format
Journal
eISSN
1335-8871
First Published
07 Mar 2008
Publication timeframe
6 times per year
Languages
English
Model Based Determination of Detection Limits for Proton Transfer Reaction Mass Spectrometer

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a chemical ionization mass spectrometric technique which allows to measure trace gases as, for example, in exhaled human breath. The quantification of compounds at low concentrations is desirable for medical diagnostics. Typically, an increase of measuring accuracy can be achieved if the duration of the measuring process is extended. For real time measurements the time windows for measurement are relatively short, in order to get a good time resolution (e.g. with breath-to-breath resolution during exercise on a stationary bicycle). Determination of statistical detection limits is typically based on calibration measurements, but this approach is limited, especially for very low concentrations. To overcome this problem, a calculation of limit of quantification (LOQ) and limit of detection (LOD), respectively, based on a theoretical model of the measurement process is outlined.

Keywords

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