Molecular Pathogenesis of Hepatocellular Carcinoma

Long XD, Ma Y, Wei YP, Deng ZL. The polymorphisms of GSTM1, GSTT1, HYL1^*2, and XRCC1, and aflatoxin B1-related hepatocellular carcinoma in Guangxi population, China. Hepatol Res 2006; 36(1): 48-55.10.1016/j.hepres.2006.06.004Search in Google Scholar

McKillop IH, Moran DM, Jin X, Koniaris LG. Molecular pathogenesis of hepatocellular carcinoma. J Surg Res 2006; 136(1): 125-135.10.1016/j.jss.2006.04.013Search in Google Scholar

Nam SW, Park JY, Ramasamy A, Shevade S, Islam A, Long PM, Park CK, Park SE, Kim SY, Lee SH, Park WS, Yoo NJ, Liu ET, Miller LD, Lee JY. Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling. Hepatology 2005; 42(4): 809-818.10.1002/hep.20878Search in Google Scholar

Panga R, Tsea E, Poon RTP. Molecular pathways in hepatocellular carcinoma. Cancer Lett 2006; 240(2): 157-169.10.1016/j.canlet.2005.08.031Search in Google Scholar

Hsiang C-Y, Wu S-L, Chen J-C, Lo H-Y, Li C-C, Chiang S-Y, Wu H-C, Ho T-Y. Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-κB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells: association with the invasive potential. Toxicol Lett 2007; 171(1-2): 78-86.10.1016/j.toxlet.2007.04.009Search in Google Scholar

Djordjević D, Nikolić J, Stefanović V. Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens. Pathol Biol 1998; 46(10): 760-70.Search in Google Scholar

Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000; 10(3):185-200.10.1006/scbi.2000.0319Search in Google Scholar

Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007; 27(1): 55-76.10.1055/s-2006-960171Search in Google Scholar

Nishimura T, Nishida N, Komeda T, Fukuda Y, Ikai I, Yamaoka Y, Nakao K. Genome-wide semiquantitative microsatellite analysis of human hepatocellular carcinoma: discrete mapping of smallest region of overlap of recurrent chromosomal gains and losses. Cancer Genet Cytogenet 2006; 167(1): 57-65.10.1016/j.cancergencyto.2005.09.002Search in Google Scholar

Buendia, MA. Tumor suppressors in hepatocellular carcinoma: many are called, but few are chosen. J Hepatol 2007; 46(4): 546-548.10.1016/j.jhep.2007.01.005Search in Google Scholar

Pogribny IP, James SJ. Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation. Cancer Lett 2002; 176(2): 169-174.10.1016/S0304-3835(01)00748-0Search in Google Scholar

Calvisi DF, Conner EA, Ladu S, Lemmer ER, Factor VM, Thogeirsson SS. Activation of the canonical Wnt/β-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J Hepatol 2005; 42(6):842-849.10.1016/j.jhep.2005.01.029Search in Google Scholar

Nakamoto Y, Guidotti LG, Kuhlen CV, Fowler P, Chisari FV. Immune pathogenesis of hepatocellular carcinoma. J Exp Med 1998; 188(2): 341-350.10.1084/jem.188.2.341Search in Google Scholar

Li B, Gao B, Ye L, Han X, Wang W, Kong L, Fang X, Zeng Y, Zheng H, Li S, Wu Z, Ye L. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res 2007; 124(1-2): 44-49.10.1016/j.virusres.2006.09.011Search in Google Scholar

Cougot D, Neuveut C, Buendia MA. HBV-induced carcinogenesis. J Clin Virol 2005; 34(Suppl 1): S75-S78.10.1016/S1386-6532(05)80014-9Search in Google Scholar

Zhang X, Zhang H, Ye L. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med 2006; 147(2): 58-66.10.1016/j.lab.2005.10.00316459163Search in Google Scholar

Cha C, DeMatteo RP. Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol 2005; 19(1): 25-37.10.1016/j.bpg.2004.11.00515757803Search in Google Scholar

Feitelson MA. Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma. Cancer Lett 2006; 239(1): 10-20.10.1016/j.canlet.2005.07.00916154256Search in Google Scholar

Wei W, Huang W, Pan Y, Zhu F, Wu J. Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras. Cancer Lett 2006; 244(1): 119-128.10.1016/j.canlet.2005.12.00816569476Search in Google Scholar

Kang-Park S, Lee JH, Shin JH, Lee YI. Activation of the IGF-II gene by HBV-X protein requires PKC and p44/p42 map kinase signalings. Biochem Biophys Res Commun 2001; 283(2): 303-307.10.1006/bbrc.2001.476711327698Search in Google Scholar

Kang-Park S, Im JH, Lee JH, Lee YI. PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells. Virus Res 2006; 122(1-2): 53-60.10.1016/j.virusres.2006.06.01016872708Search in Google Scholar

Henkler F, Hoare J, Waseem N, Goldin RD, McGarvey MJ, Koshy R, King IA. Intracellular localization of the hepatitis B virus HBx protein. J Gen Virol 2001; 82: 871-882.10.1099/0022-1317-82-4-871Search in Google Scholar

Kim KM, Kwon S-N, Kang J-I, Lee SH, Jang SK, Ahn B-Y, Kim YK. Hepatitis C virus NS2 protein activates cellular cyclic AMP-dependent pathways. Biochem Biophys Res Commun 2007; 356(4): 948-954.10.1016/j.bbrc.2007.03.070Search in Google Scholar

Baek K-H, Park H-Y, Kang C-M, Kim S-J, Jeong S-J, Hong E-K, Park J-W, Sung Y-C, Suzuki T, Kim C-M, Lee C-W. Overexpression of hepatitis C birus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation. J Mol Biol 2006; 359(1): 22-34.10.1016/j.jmb.2006.03.020Search in Google Scholar

Wang J, Tong W, Zhang X, Chen L, Yi Z, Pan T, Hu Y, Xiang L, Yuan Z. Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. FEBS Lett 2006; 580(18): 4392-4400.10.1016/j.febslet.2006.07.002Search in Google Scholar

Basu A, Meyer K, Lai KK, Saito K, Di Bisceglie AM, Grosso LE, Ray RB, Ray R. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes. Virology 2006; 349(2): 347-358.10.1016/j.virol.2006.02.023Search in Google Scholar

Nguyen H, Sankaran S, Dandekar S. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. Virology 2006; 354(1): 58-68.10.1016/j.virol.2006.04.028Search in Google Scholar

Wang J-S, Groopman JD. DNA damage by mycotoxins. Mutat Res 1999; 424(1-2): 167-181.10.1016/S0027-5107(99)00017-2Search in Google Scholar

Jackson PE, Groopman JD. Aflatoxin and liver cancer. Bailliere's Clin Gastroenterol 1999; 13(4): 545-555.10.1053/bega.1999.004710654919Search in Google Scholar

Ming L, Thorgeirsson SS, Gail MH, Lu P, Harris CC, Wang N, Shao Y, Wu Z, Liu G, Wang X, Sun Z. Dominant Role of Hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology 2002; 36(5): 1214-1220.10.1053/jhep.2002.3636612395332Search in Google Scholar

Asare GA, Bronz M, Naidoo V, Kew MC. Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis. Toxicology 2007; 234(3): 157-166.10.1016/j.tox.2007.02.00917399882Search in Google Scholar

Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology 2004; 127(5): S87-S96.10.1053/j.gastro.2004.09.020Search in Google Scholar

Balasubramaniyan V, Shukla R, Murugaiyan G, Bhonde RR, Nalini N. Mouse recombinant leptin protects human hepatoma HepG2 against apoptosis, TNF-α response and oxidative stress induced by the hepatotoxin-ethanol. Biochim Biophys Acta 2007; 1770(8): 1136-1144.10.1016/j.bbagen.2007.04.009Search in Google Scholar

Loguercio C, Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radic Biol Med 2003; 34(1): 1-10.10.1016/S0891-5849(02)01167-XSearch in Google Scholar

McKillop IH, Schrum LW. Alcohol and liver cancer. Alcohol 2005; 35(3): 195-203.10.1016/j.alcohol.2005.04.00416054981Search in Google Scholar