<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (<bold>1</bold>), (-)-neoliquiritin (<bold>2</bold>), isoliquiritigenin (<bold>3</bold>), isoliquiritin (<bold>4</bold>) and formononetin (<bold>5</bold>) from the twigs of <italic>Jacaranda obtusifolia</italic> H. B. K. ssp. <italic>rhombifolia</italic> (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds <bold>1</bold> and <bold>3</bold> were demonstrated to be inhibitory <italic>in vitro</italic> against NCI-H187 (small cell lung cancer) with <italic>IC</italic>50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).</abstract>

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).

The isolation of bioactive flavonoids from <italic>Jacaranda obtusifolia</italic> H. B. K. ssp. <italic>rhombifolia</italic> (G. F. W. Meijer) Gentry

Faculty of Pharmacy, Department of Pharmaceutical Science, Chiang Mai University, Chiang Mai, 50200 Thailand

Faculty of Science, Department of Chemistry and Center for Innovation in Chemistry, Chiang Mai University Chiang Mai, 50200 Thailand

School of Chemistry, University of Wollongong, Wollongong, NSW 2522 Australia

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072 Australia

Acta Pharmaceutica

The isolation of bioactive flavonoids from  H. B. K. ssp.  (G. F. W. Meijer) Gentry

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin...

The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry

Published Online: Jun 28, 2012

Page range: 181 - 190

DOI: https://doi.org/10.2478/v10007-012-0014-1

Keywords
(), flavonoidi, antitumorsko djelovanje

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