<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Ethanolic extract (50 %) of stems of <italic>Calotropis gigantea</italic> R. Br. (<italic>Asclepiadaceae</italic>) at doses of 250 and 500 mg kg-1 were studied for hepatoprotective activity in male Wistar rats with liver damage induced using carbon tetrachloride, 2 mL kg-1 twice a week. The protective effect of <italic>C. gigantea</italic> extract was compared with the standard drug silymarin. Various biochemical parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), glutathione (GSH), lipid peroxide (LPO), superoxidedismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated. The results revealed that the <italic>C. gigantea</italic> extract significantly decreased AST, ALT (<italic>p</italic> &lt; 0.001) and lipid peroxide (<italic>p</italic> &lt; 0.01) levels. The antioxidant parameters GSH, GPx, SOD and catalase levels were increased considerably compared to their levels in groups not treated with <italic>C. gigantea</italic> extract.</abstract>

Ethanolic extract (50 %) of stems of Calotropis gigantea R. Br. (Asclepiadaceae) at doses of 250 and 500 mg kg-1 were studied for hepatoprotective activity in male Wistar rats with liver damage induced using carbon tetrachloride, 2 mL kg-1 twice a week. The protective effect of C. gigantea extract was compared with the standard drug silymarin. Various biochemical parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), glutathione (GSH), lipid peroxide (LPO), superoxidedismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated. The results revealed that the C. gigantea extract significantly decreased AST, ALT (p < 0.001) and lipid peroxide (p < 0.01) levels. The antioxidant parameters GSH, GPx, SOD and catalase levels were increased considerably compared to their levels in groups not treated with C. gigantea extract.

Hepatoprotective effects of <italic>Calotropis gigantea</italic> extract against carbon tetrachloride induced liver injury in rats

Department of Pharmacology and Therapeutics, Chatrapati Sahuji Maharaj Medical University, Lucknow-226003, India

Hygia Institute of Pharmaceutical, Education and Research, Faizullahganj, Lucknow-226020, India

Acta Pharmaceutica

Hepatoprotective effects of  extract against carbon tetrachloride induced liver injury in rats

Ethanolic extract (50 %) of stems of Calotropis gigantea R. Br. (Asclepiadaceae) at doses of 250 and 500 mg kg-1 were studied for hepatoprotective activity in...

Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats

Published Online: Mar 20, 2009

Page range: 89 - 96

DOI: https://doi.org/10.2478/v10007-009-0002-2

Keywords
(), hepatoprotektivno djelovanje, enzimi seruma, antioksidansi

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