<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Bone tissue engineering is a multidisciplinary concept that combines biological and engineering principles to repair bone defects. Three elements that have a fundamental role in bone tissue engineering are scaffolds, stem cells, and bioactive components. Scaffolds mimic extracellular matrix functions and provide mechanical support for the new tissue formation. They are made of different natural and synthetic materials that can be categorized into three main groups: ceramics, metals, and polymers. Among them, synthetic polyesters and their combination with bioceramics, have been the most frequently used for scaffold fabrication. They could be potentially applied in clinical practice in the future as an alternative to the standard use of bone grafts but more studies are needed to assess their performance in the challenging conditions of human bone defects.</p>
</abstract>

Bone tissue engineering is a multidisciplinary concept that combines biological and engineering principles to repair bone defects. Three elements that have a fundamental role in bone tissue engineering are scaffolds, stem cells, and bioactive components. Scaffolds mimic extracellular matrix functions and provide mechanical support for the new tissue formation. They are made of different natural and synthetic materials that can be categorized into three main groups: ceramics, metals, and polymers. Among them, synthetic polyesters and their combination with bioceramics, have been the most frequently used for scaffold fabrication. They could be potentially applied in clinical practice in the future as an alternative to the standard use of bone grafts but more studies are needed to assess their performance in the challenging conditions of human bone defects.

The Use of Newly Synthesized Composite Scaffolds for Bone Regeneration - A Review of Literature

Department of Dentistry, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Bone tissue engineering is a multidisciplinary concept that combines biological and engineering principles to repair bone defects. Three elements that have a...

The Use of Newly Synthesized Composite Scaffolds for Bone Regeneration - A Review of Literature

Published Online: Dec 31, 2022

Page range: -

Received: Nov 25, 2021

Accepted: Dec 10, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0071

Keywords
Bone tissue engineering, scaffold, hydroxyapatite, poly(lactic acid), polyethylenimine

© 2022 Momir Stevanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Use of Newly Synthesized Composite Scaffolds for Bone Regeneration - A Review of Literature

Published Online: Dec 31, 2022

Page range: -

Received: Nov 25, 2021

Accepted: Dec 10, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0071

KeywordsBone tissue engineering, scaffold, hydroxyapatite, poly(lactic acid), polyethylenimine

© 2022 Momir Stevanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Bone tissue engineering, scaffold, hydroxyapatite, poly(lactic acid), polyethylenimine