<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Changes in the body in the presence of a chronic inflammatory process, even of a low intensity, lead to the change in the body’s reactivity, having a negative impact on the development, course and clinical prognosis of newly emerging inflammatory processes. Structural changes in the vascular network in the focus of chronic inflammation and following cellular reactions that occur under the action of chemokines and cytokines are the basis for the maintenance and development of the phlogogenic process, including subsequent structural changes in tissues. The failure to resolve the inflammation leads not only to the persistence of the process in the primary focus, but also to the formation of a multitude of the so-calledpathological circles, included at the system level, causing the imbalance among proinflammatory, anti-inflammatory and pro-resolving factors. As a result, conditions are formed for the emergence of new foci of the inflammation in other organs and tissues and in the case of their realization, new vicious circles are formed that contribute to the maintenance and progression of the inflammation. The complex application of etio-tropic, pathogenetic and sanogenetic principles of the treatment allows intensifying of the formation of specialized pro-resolving factors with the elimination of their relative insufficiency, contributing to the reduction of newly formed vessels and to the restoration of the normal cellular composition of the tissue as well as to the resolution of inflammation.</p></abstract>

Changes in the body in the presence of a chronic inflammatory process, even of a low intensity, lead to the change in the body’s reactivity, having a negative impact on the development, course and clinical prognosis of newly emerging inflammatory processes. Structural changes in the vascular network in the focus of chronic inflammation and following cellular reactions that occur under the action of chemokines and cytokines are the basis for the maintenance and development of the phlogogenic process, including subsequent structural changes in tissues. The failure to resolve the inflammation leads not only to the persistence of the process in the primary focus, but also to the formation of a multitude of the so-calledpathological circles, included at the system level, causing the imbalance among proinflammatory, anti-inflammatory and pro-resolving factors. As a result, conditions are formed for the emergence of new foci of the inflammation in other organs and tissues and in the case of their realization, new vicious circles are formed that contribute to the maintenance and progression of the inflammation. The complex application of etio-tropic, pathogenetic and sanogenetic principles of the treatment allows intensifying of the formation of specialized pro-resolving factors with the elimination of their relative insufficiency, contributing to the reduction of newly formed vessels and to the restoration of the normal cellular composition of the tissue as well as to the resolution of inflammation.

Influence of Systemic Inflammatory Response to Appearance of New Foci of Chronic Inflammation

I.M. Sechenov First Moscow State Medical University

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Changes in the body in the presence of a chronic inflammatory process, even of a low intensity, lead to the change in the body’s reactivity, having a negative...

Influence of Systemic Inflammatory Response to Appearance of New Foci of Chronic Inflammation

Published Online: Jun 05, 2020

Page range: 3 - 10

Received: Feb 17, 2020

Accepted: Feb 23, 2020

DOI: https://doi.org/10.2478/sjecr-2020-0013

Keywords
specialized permissive mediators, chronic cytokine response, imbalance of counter-regulatory factors

© 2020 Denis Dmitrievich Bolotov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Influence of Systemic Inflammatory Response to Appearance of New Foci of Chronic Inflammation

Published Online: Jun 05, 2020

Page range: 3 - 10

Received: Feb 17, 2020

Accepted: Feb 23, 2020

DOI: https://doi.org/10.2478/sjecr-2020-0013

Keywordsspecialized permissive mediators, chronic cytokine response, imbalance of counter-regulatory factors

© 2020 Denis Dmitrievich Bolotov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
specialized permissive mediators, chronic cytokine response, imbalance of counter-regulatory factors