<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of the solution and cysteine addition on the size distribution and hydrodynamic size of nanoparticles were studied via TEM and PCS methods, respectively. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. Coating density was calculated using TGA and TEM results. Cytotoxicity assessment performed by incubation of L929 cells, confirmed that ferrofluids are biocompatible. MRI studies conducted on rats demonstrated suitability of synthesized nanoparticles as contrast agents, especially for imaging of the lymph nodes.</p></abstract>

Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of the solution and cysteine addition on the size distribution and hydrodynamic size of nanoparticles were studied via TEM and PCS methods, respectively. The crystal structure and magnetic properties of the nanoparticles were characterized by XRD and VSM techniques, respectively. Coating density was calculated using TGA and TEM results. Cytotoxicity assessment performed by incubation of L929 cells, confirmed that ferrofluids are biocompatible. MRI studies conducted on rats demonstrated suitability of synthesized nanoparticles as contrast agents, especially for imaging of the lymph nodes.

Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution

Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran

Young Researchers Club, East Tehran Branch, Islamic Azad University, Tehran, Iran

Jiangsu Key Laboratory of Biomaterials and Devices, Nanjing, China

Materials Science-Poland

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cysteine capped magnetite nanoparticles (10 to 20 nm) were synthesized via coprecipitation method under ultrasonic irradiation. The influence of pH value of...

Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution

Published Online: Dec 14, 2012

Page range: 382 - 389

DOI: https://doi.org/10.2478/s13536-012-0048-6

Keywords
coprecipitation, nanoparticles, electron microscopy, biocompatibility

© 2012 Wroclaw University of Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesizing cysteine-coated magnetite nanoparticles as MRI contrast agent: Effect of pH and cysteine addition on particles size distribution

Published Online: Dec 14, 2012

Page range: 382 - 389

DOI: https://doi.org/10.2478/s13536-012-0048-6

Keywordscoprecipitation, nanoparticles, electron microscopy, biocompatibility

© 2012 Wroclaw University of Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
coprecipitation, nanoparticles, electron microscopy, biocompatibility