Evaluation of cytotoxicity and apoptotic effects of Catharanthus roseus on the human lung cancer cell lines CaLu-6

1 Abizov EA, Tolkachev ON, Mal’tsev SD, Abizova EV. Composition of biologically active substances isolated from the fruits of Russian olive (Elaeagnus angustifolia) introduced in the European part of Russia. Pharm Chem J. (2008) 42:696-8. DOI: 10.1007/s11094-009-0203-5 Search in Google Scholar

2 Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ID, et al. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets. 2006 Feb;10(1):87-118. DOI: 10.1517/14728222.10.1.87 Search in Google Scholar

3 Bannazadeh Amirkhiz M, Rashtchizadeh N, Nazemieh H, Abdolalizadeh J, Mohammadnejad L, Baradaran B. Cytotoxic effects of alcoholic extract of dorema glabrum seed on cancerous cells viability. Adv Pharm Bull. 2013;3(2):403-8. DOI: 10.1155/2013/949871 Search in Google Scholar

4 Chaudhry GE, Md Akim A, Sung YY, Sifzizul TMT. Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Front Pharmacol. 2022 Aug 10;13:842376. DOI: 10.3389/fphar.2022.842376 Search in Google Scholar

5 Chen R, Manochakian R, James L, Azzouqa AG, Shi H, Zhang Y, et al. Emerging therapeutic agents for advanced non-small cell lung cancer. J Hematol Oncol. 2020 May 24;13(1):58. DOI: 10.1186/s13045-020-00881-7 Search in Google Scholar

6 Couraud S, Zalcman G, Milleron B, Morin F, Souquet PJ. Lung cancer in never smokers--a review. Eur J Cancer. 2012 Jun;48(9):1299-311. DOI: 10.1016/j.ejca.2012.03.007 Search in Google Scholar

7 Don G. Catharanthus roseus. In: Ross IA, editor. Medicinal plants of the world: Chemical constituents, traditional and modern uses, vol 1. Totowa, New Jersey, USA: Humana Press; 2003. pp. 175-196. Search in Google Scholar

8 Fouzat A, Hussein OJ, Gupta I, Al-Farsi HF, Khalil A, Al Moustafa AE. Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells. Front Nutr. 2022 Mar 18;9:871667. DOI: 10.3389/fnut.2022.871667 Search in Google Scholar

9 Hao J, Zheng L, Han Y, Zhang H, Hou K, Liang X, et al. Genome-wide identification and expression analysis of TCP family genes in Catharanthus roseus. Front Plant Sci. 2023 Apr 12;14:1161534. DOI: 10.3389/fpls.2023.1161534 Search in Google Scholar

10 Isenberg JS, Klaunig JE. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol Sci. 2000 Feb;53(2):340-51. DOI: 10.1093/toxsci/53.2.340 Search in Google Scholar

11 Kheraldine H, Gupta I, Alhussain H, Jabeen A, Cyprian FS, Akhtar S, et al. Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways. Comput Struct Biotechnol J. 2021 May 7;19:2881-90. DOI: 10.1016/j.csbj.2021.05.011 Search in Google Scholar

12 Sudhakar M, Venkata Raman B. Bactericidal and Anti-biofilm Activity of Tannin Fractions Derived from Azadirachta against Streptococcus mutans. Asian J Appl Sci. 2020;13:132-43. DOI: 10.3923/ajaps.2020.132.143 Search in Google Scholar

13 Orellana EA, Kasinski AL. Sulforhodamine B (SRB) Assay in Cell Culture to Investigate Cell Proliferation. Bio Protoc. 2016 Nov 5;6(21):e1984. DOI: 10.21769/BioProtoc.1984 Search in Google Scholar

14 Patel RM, Patel SK. Cytotoxic activity of methanolic extract of Artocarpus heterophyllus against A549, Hela and MCF-7 cell lines. J App Pharm Sci. 2011;1:167-71. Search in Google Scholar

15 Patel S, Gheewala N, Suthar A, Shah A. In-vitro cytotoxicity activity of Solanum nigrum extract against Hela cell line and Vero cell line. Int J Pharm Pharm Sci. 2009;1:38-46. Search in Google Scholar

16 Pham HNT, Vuong QV, Bowyer MC, Scarlett CJ. Phytochemicals Derived from Catharanthus roseus and Their Health Benefits. Technologies. 2020;8(4):80. DOI: 10.3390/technologies8040080 Search in Google Scholar

17 Rajashekara S, Reena D, Mainavi MV, Sandhya LS, Baro U. Biological isolation and characterization of Catharanthus roseus (L.) G. Don methanolic leaves extracts and their assessment for antimicrobial, cytotoxic, and apoptotic activities. BMC Complement Med Ther. 2022 Dec 9;22(1):328. DOI: 10.1186/s12906-022-03810-y Search in Google Scholar

18 Salam A, Sudhakar M. Cytotoxicity and expression studies of angiogenesis-promoting genes in cancer cell lines under the treatment of cancer candidate drugs, Asian J Pharm Clin Res2019;12(5):130-34. DOI: 10.22159/ajpcr.2019.v12i5.31929 Search in Google Scholar

19 Saleh AI, Mohamed I, Mohamed AA, Abdelkader M, Yalcin HC, Aboulkassim T, et al. Elaeagnus angustifolia Plant Extract Inhibits Angiogenesis and Downgrades Cell Invasion of Human Oral Cancer Cells via Erk1/Erk2 Inactivation. Nutr Cancer. 2018 Feb-Mar;70(2):297-305. DOI: 10.1080/01635581.2018.1412472 Search in Google Scholar

20 Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020 Jan;70(1):7-30. DOI: 10.3322/caac.21590 Search in Google Scholar

21 Škubník J, Pavlíčková VS, Ruml T, Rimpelová S. Vincristine in Combination Therapy of Cancer: Emerging Trends in Clinics. Biology (Basel). 2021 Aug 31;10(9):849. DOI: 10.3390/biology10090849 Search in Google Scholar

22 Sottomayor M, Ros Barceló A. The Vinca alkaloids: From biosynthesis and accumulation in plant cells, to uptake, activity and metabolism in animal cells. In: Rahman A, editor. Studies in natural products chemistry (bioactive natural products) The Netherlands: Elsevier Science Publishers; 2005. pp. 813-857. DOI: 10.1016/S1572-5995(06)80041-4 Search in Google Scholar

23 Vajrabhaya Lo, Korsuwannawong S. Cytotoxicity evaluation of a Thai herb using tetrazolium (MTT) and sulforhodamine B (SRB) assays. J Anal Sci Technol. 2018;9:15. DOI: 10.1186/s40543-018-0146-0 Search in Google Scholar

24 Van der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R. The Catharanthus alkaloids: Pharmacognosy and biotechnology. Current Medicinal Chemistry. 2004;11(5):607-28. DOI: 10.2174/0929867043455846 Search in Google Scholar

25 Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssière JL, Petit PX, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med. 1995 May 1;181(5):1661-72. DOI: 10.1084/jem.181.5.1661 Search in Google Scholar