<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction</bold>: Stroke is a disease with high mortality and morbidity. Currently, there are no specific laboratory markers that can replace or improve clinical and radiological diagnosis and prognosis. We evaluated the role of C-reactive protein (CRP), fibrinogen and D-dimer in predicting short-term outcomes in acute ischemic stroke.
<bold>Methods</bold>: We included 118 acute ischemic stroke patients, admitted within 24 h of onset, mean age 72.73±10.08 years. The severity of the stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS), and for poor outcome (PO) we accepted a severe functional deficit at the end of the hospital stay with NIHSS ≥15, and for good outcome (GO) – NIHSS ≤ 14. In all patients, we monitored the dynamics of CRP, fibrinogen and D-dimer and evaluated their predictive value regarding to the PO and GO of the stroke.
<bold>Results</bold>: D-dimer had the strongest poor predictive value at admission (p&lt;0.001). Six hours after admission, CRP, D-dimer or both were higher in PO patients (p=0.046, p=0.022 and p=0.006, respectively). At the 24.h, only CRP could be used to predict PO (p&lt;0.001). Elevated CRP, D-dimer or both have been determined as strong indicators of PO with 72 hours of admission (p&lt;0.001, p=0.032 and p=0.001, respectively). Fibrinogen levels were higher 72 hours after admission without a significant relationship with the NIHSS.
<bold>Conclusion</bold>: Changes in routine biomarkers CRP and D-dimer, but not fibrinogen, can predict short-term stroke prognosis and may be associated with the risk of early neurological deterioration or death during hospital stay.
</abstract>

Introduction: Stroke is a disease with high mortality and morbidity. Currently, there are no specific laboratory markers that can replace or improve clinical and radiological diagnosis and prognosis. We evaluated the role of C-reactive protein (CRP), fibrinogen and D-dimer in predicting short-term outcomes in acute ischemic stroke.
Methods: We included 118 acute ischemic stroke patients, admitted within 24 h of onset, mean age 72.73±10.08 years. The severity of the stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS), and for poor outcome (PO) we accepted a severe functional deficit at the end of the hospital stay with NIHSS ≥15, and for good outcome (GO) – NIHSS ≤ 14. In all patients, we monitored the dynamics of CRP, fibrinogen and D-dimer and evaluated their predictive value regarding to the PO and GO of the stroke.
Results: D-dimer had the strongest poor predictive value at admission (p<0.001). Six hours after admission, CRP, D-dimer or both were higher in PO patients (p=0.046, p=0.022 and p=0.006, respectively). At the 24.h, only CRP could be used to predict PO (p<0.001). Elevated CRP, D-dimer or both have been determined as strong indicators of PO with 72 hours of admission (p<0.001, p=0.032 and p=0.001, respectively). Fibrinogen levels were higher 72 hours after admission without a significant relationship with the NIHSS.
Conclusion: Changes in routine biomarkers CRP and D-dimer, but not fibrinogen, can predict short-term stroke prognosis and may be associated with the risk of early neurological deterioration or death during hospital stay.

Evaluation of routine laboratory markers as short-term outcome indicators in patients with acute ischemic stroke

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction: Stroke is a disease with high mortality and morbidity. Currently, there are no specific laboratory markers that can replace or improve clinical...

Evaluation of routine laboratory markers as short-term outcome indicators in patients with acute ischemic stroke

Published Online: May 02, 2024

Page range: 155 - 162

Received: Feb 05, 2024

Accepted: Mar 06, 2024

DOI: https://doi.org/10.2478/rrlm-2024-0011

Keywords
CRP, D-dimer, fibrinogen, ischemic stroke, laboratory markers

© 2024 Tatyana Popovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Evaluation of routine laboratory markers as short-term outcome indicators in patients with acute ischemic stroke

Published Online: May 02, 2024

Page range: 155 - 162

Received: Feb 05, 2024

Accepted: Mar 06, 2024

DOI: https://doi.org/10.2478/rrlm-2024-0011

KeywordsCRP, D-dimer, fibrinogen, ischemic stroke, laboratory markers

© 2024 Tatyana Popovska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
CRP, D-dimer, fibrinogen, ischemic stroke, laboratory markers