Association of C5a/C5aR pathway to activate ERK1/2 and p38 MAPK in acute kidney injury – a mouse model

1. Gyal A, Daneshpajouhnejad P, Hashmi M. F, Bashir K. Acute Kidney Injury. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan; PMID: 28722925.Search in Google Scholar

2. Ostermann M, Liu K. Pathophysiology of AKI. Best Pract Res Clin Anaesthesiol. 2017 Sep; 31(3):305-14. DOI: 10.1016/j.bpa.2017.09.00110.1016/j.bpa.2017.09.001Search in Google Scholar

3. Lande R. E, Blackburn R. Evaluating pharmacist training. Popul Rep J. 1989 Nov;(37):26-8.Search in Google Scholar

4. Pei G, Zhang Z. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020 Jun; 31(6):1157-65. DOI: 10.1681/ASN.202003027610.1681/ASN.2020030276Search in Google Scholar

5. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020 Mar; 31(368):m1091. DOI: 10.1136/bmj.m109110.1136/bmj.m1091Search in Google Scholar

6. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020 Mar; 395(10229):1054-62. DOI: 10.1016/S0140-6736(20)30566-310.1016/S0140-6736(20)30566-3Search in Google Scholar

7. Cao J, Tu WJ, Cheng W, Yu L, Liu YK, Hu X, et al. Clinical Features and Short-term Outcomes of 102 Patients with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis. 2020 Jul; 71(15):748-55. DOI: 10.1093/cid/ciaa24310.1093/cid/ciaa243718447932239127Search in Google Scholar

8. Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, Barnett RL, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020 Jul; 98(1):209-18. DOI: 10.1016/j.kint.2020.05.00610.1016/j.kint.2020.05.006722946332416116Search in Google Scholar

9. Nishida K, Watanabe H, Miyahisa M, Hiramoto Y, Nosaki H, Fujimura R, et al. Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice. Sci Rep. 2020 Nov; 10(1):20635. DOI: 10.1038/s41598-020-75025-510.1038/s41598-020-75025-5769134333244034Search in Google Scholar

10. Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, et al. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 Dec,16(12):747-74. DOI: 10.1038/s41581-020-00356-510.1038/s41581-020-00356-5756124633060844Search in Google Scholar

11. Markiewski MM, Lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol. 2007 Sep;171(3):715-27. DOI: 10.2353/ajpath.2007.07016610.2353/ajpath.2007.070166195948417640961Search in Google Scholar

12. Jeon H, Han SR, Lee S, Park SJ, Kim JH, Yoo SM, et al. Activation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors. Sci Rep. 2018 April; 8:5415. DOI: 10.1038/s41598-018-23851-z10.1038/s41598-018-23851-z588303329615744Search in Google Scholar

13. Liu XY, Wang XY, Li RY, Jia SC, Sun P, Zhao M, et al. Recent progress in the understanding of complement activation and its role in tumor growth and anti-tumor therapy. Biomed Pharmacother. 2017Jul; 91:446-56. DOI: 10.1016/j.biopha.2017.04.10110.1016/j.biopha.2017.04.10128477461Search in Google Scholar

14. Afshar-Kharghan V. The role of the complement system in cancer. J Clin Invest. 2017 Mar; 127(3):780-9. DOI: 10.1172/JCI9096210.1172/JCI90962533075828248200Search in Google Scholar

15. Schraufstatter IU, Trieu K, Sikora L, Sriramarao P, DiScipio R. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol. 2002 Aug; 169(10):2102-10. DOI: 10.4049/jimmunol.169.4.210210.4049/jimmunol.169.4.210212165538Search in Google Scholar

16. Monsinjon T, Gasque P, Chan P, Ischenko A, Brady JJ, Fontaine MC. Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells. Faseb j. 2003 Jun;17(9):1003-14. DOI: 10.1096/fj.02-0737com10.1096/fj.02-0737com12773483Search in Google Scholar

17. Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, et al. CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP- K2-HSP27 pathway. Cell Signal. 2006 Nov; 18(11):1897-905. DOI: 10.1016/j.cellsig.2006.02.00610.1016/j.cellsig.2006.02.00616574378Search in Google Scholar

18. Markiewski MM, DeAngelis RA, Strey CW, Foukas PG, Gerard C, Gerard N, et al. The regulation of liver cell survival by complement. J Immunol. 2009 May; 182(9):5412-8. DOI: 10.4049/jimmunol.080417910.4049/jimmunol.0804179273212819380788Search in Google Scholar

19. Albert-Gascó H, Ros-Bernal F. MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes. Int J Mol Sci. 2020 Jun; 21(12):4471. DOI: 10.3390/ijms2112447110.3390/ijms21124471735286032586047Search in Google Scholar

20. El Rawas R, Amaral IM. Is p38 MAPK Associated to Drugs of Abuse-Induced Abnormal Behaviors? Int J Mol Sci. 2020 Jul; 21(14):4833. DOI:10.3390/ijms 21144833. DOI: 10.3390/ijms10.3390/ijmsSearch in Google Scholar

21. Sun Y, Liu WZ, Liu T, Feng X, Yang N, Zhou HF. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015 Jun; 35(6):600-4. DOI: 10.3109/10799893.2015.103041210.3109/10799893.2015.103041226096166Search in Google Scholar

22. Davidson SM, Arjun S, Basalay MV, Bell RM, Bromage DI, Bøtker HE, et al. The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocar-dial infarction, ischaemic stroke, and cardio-oncology. Basic Res Cardiol 2018 Oct; 113(6):43. DOI: 10.1007/s00395-018-0704-z10.1007/s00395-018-0704-z618268430310998Search in Google Scholar

23. Dong Q, Jie Y, Ma J, Li C, Xin T, Yang D. Renal tubular cell death and inflammation response are regulated by the MAPK-ERK-CREB signaling pathway under hypoxia-reoxygenation injury. J Recept Signal Transduct Res. 2019 Oct-Dec; 39(5-6):383-91. DOI: 10.1080/10799893.2019.169805010.1080/10799893.2019.1698050Search in Google Scholar

24. Levey AS, James MT. Acute Kidney Injury. Ann Intern Med. 2017 Nov; 167(9):ITC66-80. DOI: 10.7326/AITC20171107010.7326/AITC201711070Search in Google Scholar

25. Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G. Rationale for targeting complement in COVID-19. EMBO Mol Med. 2020 Aug; 12(8):e12642. DOI: 10.15252/emmm.20201264210.15252/emmm.202012642Search in Google Scholar

26. Hammerschmidt DE, Weaver LJ, Hudson LD, Crad-dock PR, Jacob HS. Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value. Lancet 1980 May; 1(8175):947-9. DOI: 10.1016/S0140-6736(80)91403-810.1016/S0140-6736(80)91403-8Search in Google Scholar

27. Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, et al. Functional roles for C5a receptors in sepsis. Nat Med. 2008 May; 14(5):551-7. DOI: 10.1038/nm175310.1038/nm1753275385818454156Search in Google Scholar

28. Skausig O. B, Lversen O. Severe paresis caused by electrolyte disturbances following end-to-side jejunoileostomy for morbid obesity. Dan Med Bull. 1979 Nov;26(7):344-5.Search in Google Scholar

29. Tsai JP, Lee CJ, Subeq YM, Lee RP, Hsu BG. Acute Alcohol Intoxication Exacerbates Rhabdomyolysis-Induced Acute Renal Failure in Rats. Int J Med Sci. 2017 Jun 23;14(7):680-9. DOI: 10.7150/ijms.19479.10.7150/ijms.19479556212028824301Search in Google Scholar