[1. Nolte O. Antimicrobial resistance in the 21st century: a multifaceted challenge. Protein Pept Lett 2014; 21:330-5. DOI: 10.2174/0929866511320666010610.2174/0929866511320666010624164264]Open DOISearch in Google Scholar
[2. Thabit Ak, Crandon JL, Nicolau DP. Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials. Expert Opin Pharmacother 2015;16(2):159-77. DOI: 10.1517/14656566.2015.99338110.1517/14656566.2015.99338125496207]Open DOISearch in Google Scholar
[3. MacCarthy MW, Kontoyiannis DP, Cornely OA, Perfect JR, Walsh TJ. Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi. J Infect Dis 2017;216:474-83. DOI: 10.1093/infdis/jix13010.1093/infdis/jix13028911042]Open DOISearch in Google Scholar
[4. Rai M, Ingle AP, Pandit R, Paralikar P, Gupta I, Chaud MV, Dos Santos CA. Broadenin the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance. Int J Pharm 2017;532:139-148. DOI: 10.1016/j.ijpharm.2017.08.12710.1016/j.ijpharm.2017.08.12728870767]Open DOISearch in Google Scholar
[5. Ibrahim HM, Behbehani H, Elnagdi MH. Approaches towards the synthesis of a novel class of 2-amino- 5-arylzonicotinate, pyridazinone and pyrido[2,3-d] pyrimidine derivatives as potent antimicrobial agents. Chem Cent J 2013;7(1):123. DOI: 10.1186/1752-153X-7-12310.1186/1752-153X-7-123375145323867062]Open DOISearch in Google Scholar
[6. Singh J, Sharma D, Bansal R. Pyridazinone:an attractive lead for ant-inflamatory and analgesic drug discovery. Future Med Chem 2017;9(1):95-127. DOI: 10.4155/fmc-2016-019410.4155/fmc-2016-019427957866]Open DOISearch in Google Scholar
[7. Jaballah MY, Serya RT, Abouzid K. Pyridazinone Based Scaffods as Privileed Structures in anti-cancer Therapy. Drug Res (Stuttg) 2017;67(3):138-48. DOI: 10.1055/s-0042-11999210.1055/s-0042-11999228073115]Open DOISearch in Google Scholar
[8. Asif M. A mini review on biological activities pf pyridazinone derivatives as antiulcer, antisecretory, antihistamin and particularly against histamine H3R. Mini Rev Med Chem 2015;14(3):1093-103. DOI: 10.2174/1 389557514666141127143133]Search in Google Scholar
[9. Sukuroglu M, Onkol T, Onurdag FK, Akalin G, Sahin MF. Synthesis and in vitro biological activity of new 4,6-disubstituted 3(H)-pyridazinone-acetohydrazide derivatives. Z Naturforsch C 2012;67(5-6):257-65. DOI: 10.5560/ZNC.2012.67c025710.5560/ZNC.2012.67c0257]Open DOISearch in Google Scholar
[10. Bansal R, Sridhar T. Pyridazin-3(2H)-ones: the versatile pharmacophore of medicinal significance. Med Chem Res 2013;22:2539-52. DOI: 10.1007/s00044- 012-0261-1]Search in Google Scholar
[11. Purohit DM, Shah VH. Novel method for synthesis and antimicrobial evaluation of 2-aroyl-6-hydroxy/chloro/ hydrazino/carboxymethoxy-3(2H)-pyridazinones. Heterocycl Commun 1997;3 (3):267-272. DOI: 10.1515/HC.1997.3.3.26710.1515/HC.1997.3.3.267]Open DOISearch in Google Scholar
[12. Islam M, Siddiqui AA, Rajesh R. Synthesis antitubercular, antifungal and antibacterial activities of 6-susbtituted phenyl-2-(3’-substituded phenyl pyridazin- 6’-yl)-2,3,4,5-tetrahydropyridazin-3-one. Acta Pol Pharm 2008;65(3):353-62.]Search in Google Scholar
[13. Ozcelik AB, Gokce M, Orhan I, Kaynak F, Sahin MF. Synthesis and antimicrobial, acetylcholinesterase and butyrycholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(H)-pyridazinone. Arnzeimittelforschung 2010;60(7):452-8.]Search in Google Scholar
[14. Sonmej M, Berber L, Akbas B. Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes. Eur J Med Chem 2005;41:101-5. DOI: 10.1016/j.ejmech.2005.10.00310.1016/j.ejmech.2005.10.00316293349]Open DOISearch in Google Scholar
[15. Akbas E, Berber I. Antibacterial and antifungal activities of new pyrazolo [3,4-d]pyridazin derivatives, Eur J Med Chem 2005;40:401-5. DOI: 10.1016/j.ejmech. 2004.12.00110.1016/j.ejmech.2004.12.00115804539]Open DOISearch in Google Scholar
[16. Utku S, Gokce M, Aslan G, Bayram G, Ulger M, Emekdaş G et al. Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone- 2-acetyl-2-(substituted/nonsubstituted acetophenone) hydrazine. Turk J Chem 2011;35(2):331-9.]Search in Google Scholar
[17. Gokce M, Utku S, Kupeli E. Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone- 2-acetyl-2-(p-substituted/nonsubstituted benzal) hydrazone derivatives. Eur J Med Chem 2009;44:3760-64. DOI: 10.1016/j.ejmech.2009.04.04810.1016/j.ejmech.2009.04.04819535179]Open DOISearch in Google Scholar
[18. Jorgensen JH, Ferraro MJ. Antimicrobial suspectibility testing: general principles and comtemporary. Clin Infect Dis 1998;26:973-80. DOI: 10.1086/513938 10.1086/5139389564485]Open DOISearch in Google Scholar
[19. Woods GL, Washington JA, Antibacterial susceptibility tests: dilution and disk diffusion methods. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, eds. Manual of clinical microbiology. 6th ed. Washington, DC: American Society for Microbiology; 1995:1327-41.]Search in Google Scholar
[20. Clinical Laboratory Standards Institute. Performance Standards For Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI. M02-A11 and M07-A9, 2012:40-61.]Search in Google Scholar
[21. https://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf. [Last accested 1 August 2017].]Search in Google Scholar
[22. Lob SH, Badal RE, Hackel MA, Sahm DF. Epidemiology and antimicrobial Suspectibility of Gram-Negative Pathogens Causing Intra-abdominal Infections in Pediatrics Patients in Europe-SMART 2011-2014. J Pediatric Infect Dis Soc 2017;6(1):72-79]Search in Google Scholar
[23. Akova M. Epidemiology of antimicrobial resistance in bloodstream infections. Virulence 2016;7(3):252-66. DOI: 10.1080/21505594.2016.115936610.1080/21505594.2016.1159366487163426984779]Open DOISearch in Google Scholar
[24. Karlowksy JA, Hoban DJ, Hackel MA, Lob SH, Sahm DF. Resistance among Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Latin American countries: SMART 2013-2015. Braz J Infect Dis 2017;21(3):343-8. DOI: 10.1016/j.bjid.2017.03.00610.1016/j.bjid.2017.03.00628399424]Search in Google Scholar
[25. Koksal F, Yılmaz G, Unal S, Zarakolu P, Korten V, Mulazzimoglu L et al. Epidemiology and susceptibility of pathogens from SMART 2011-12 Turkey: evaluation of hospital-acquired versus community-acquired urinary tract infections and ICU- versus non-ICU-associated intra-abdominal infections. J Antimicrob Chemother 2017;72: 1364-72. DOI: 10.1093/jac/dkw57410.1093/jac/dkw57428122913]Open DOISearch in Google Scholar
[26. Bernabe KJ, Langendorf C, Ford N, Ronat JB, Murphy RA. Antibiotic resistance in West Africa: a systematic review and meta-analysis. International Journal of Antimicrobial Agent 2017;17: 30274-1.]Search in Google Scholar
[27. Kelly AM, Mathema B, Larson EL. Carbapenem-resistant Enterobacteriaceae in the community: a scoping review. Int J Antimicrob Agents 2017;50:127-134. DOI: 10.1016/j.ijantimicag.2017.03.01210.1016/j.ijantimicag.2017.03.012572625728647532]Open DOISearch in Google Scholar
[28. Srinivasan A, Lopez-Ribot JL, Ramasubramanian AK. Overcoming antifungal resistance. Drug Discov Today Technol 2014:65-71. DOI: 10.1016/j.ddtec.2014.02.00510.1016/j.ddtec.2014.02.005403146224847655]Open DOISearch in Google Scholar
[29. Maubon D, Garnaud C, Calandra T, Sanglard D, Cornet M. Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?. Intensive Care Med 2014;40:1241-55. DOI: 10.1007/s00134-014-3404-710.1007/s00134-014-3404-725091787]Open DOISearch in Google Scholar
[30. Ben-Ami R, Olshtain-Pops K, Krieger M et al. Antibiotic exposure as a risk factor for fluconazole-resistant Candida bloodstream infection. Antimicrob Agents Chemother 2012; 56: 2518-2523. DOI: 10.1128/AAC.05947-1110.1128/AAC.05947-11334666822314534]Open DOISearch in Google Scholar
[31. Arendrup MC. Update on antifungal resistance in Aspergillus and Candida Clin Microbiol Infect 2014; 20 (Suppl. 6): 42-48.10.1111/1469-0691.1251324372701]Open DOISearch in Google Scholar