Open Access

Editorial: Precision medicine in rhinology: Redefining diagnosis and treatment in the era of molecular individualization

  
May 26, 2025

Cite
Download Cover

Bachert C, Zhang N, Hellings PW, Bousquet J. Endotype-driven care pathways in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2018;141(5):1543-51. DOI: 10.1016/j.jaci.2018.03.004. Search in Google Scholar

Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(Suppl S29):1-464. DOI: 10.4193/Rhin20.600. Search in Google Scholar

Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, et al. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicenter, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet. 2019;394(10209):1638-50. DOI: 10.1016/S0140-6736(19)31881-1. Search in Google Scholar

Gevaert P, Omachi TA, Corren J, Mullol J, Han J, Lee SE, et al. Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials. J Allergy Clin Immunol. 2020;146(3):595-605. DOI: 10.1016/j. jaci.2020.05.032. Search in Google Scholar

Han JK, Bachert C, Fokkens WJ, Desrosiers M, Wagenmann M, Lee SE, et al. Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021;9(10):1141-53. DOI: 10.1016/S2213-2600(21)00097-7.. Search in Google Scholar

Dzaman K, Rudnicka L, Rykowska A, et al. Challenges in implementing personalized medicine in Central and Eastern Europe. Front Genet. 2020;11:550. Search in Google Scholar

Tait Wojno ED, Monticelli LA. The dynamic nasal immune landscape in chronic rhinosinusitis. Curr Opin Immunol. 2022;74:47-54. Search in Google Scholar

Topol EJ. High-performance medicine: the convergence of human and artificial intelligence. Nat Med. 2019;25(1):44-56. DOI: 10.1038/s41591-018-0300-7. Search in Google Scholar