Perfluoroalkylated substances – an endocrine disruptor with reprotoxic effects

1 European Commission. European semester-thematic factsheet. Women in the labour market. Accessed November 19, 2024. Available from: https://commission.europa.eu/document/download/b90d3b1f-870d-461c-9352-fec4bdf7e0cc_ro?filename=european-semester_thematic-factsheet_labour-force-participation-women_ro.pdf Search in Google Scholar

2 ORDIN 5707 01/08/2024 - Portal Legislativ. Accessed November 19, 2024. https://legislatie.just.ro/Public/DetaliiDocument/286827 Search in Google Scholar

3 OUG 96 14/10/2003 - Portal Legislativ. Accessed November 18, 2024. https://legislatie.just.ro/Public/DetaliiDocument/47216 Search in Google Scholar

4 Substanțe per- și polifluoroalchilice (PFAS) - ECHA. Accessed November 19, 2024. https://poisoncentres.echa.europa.eu/ro/web/guest/hot-topics/perfluoroalkyl-chemicals-pfas Search in Google Scholar

5 OECD Global Forum on the Environment dedicated to Per- and Polyfluoroalkyl Substances (PFAS). Accessed November 19, 2024. Available from: https://www.oecd.org/content/dam/oecd/en/topics/policy-sub-issues/risk-management-risk-reduction-and-sustainable-chemistry2/events/pfas-gfe-2024/global-forum-on-environment-work-on-pfass.pdf Search in Google Scholar

6 Jurnalul Oficial al Uniunii Europene. Regulamentul delegat (UE) 2020/784 al Comisiei din 8 aprilie 2020 de modificare a anexei I la Regulamentul (UE) 2019/1021 al Parlamentului European și al Consiliului în ceea ce privește includerea acidului perfluorooctanoic (PFOA), a sărurilor acestuia și a compușilor înrudiți cu acesta. Accessed November 19, 2024. Available from: https://eur-lex.europa.eu/legal-content/RO/TXT/PDF/?uri=CELEX:32020R0784&from=EN Search in Google Scholar

7 IARC Monographs evaluate the carcinogenicity of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). Accessed November 19, 2024. Available from: https://www.iarc.who.int/news-events/iarc-monographs-evaluate-the-carcinogenicity-of-perfluorooctanoic-acid-pfoa-and-perfluorooctanesulfonic-acid-pfos Search in Google Scholar

8 Substanțe per- și polifluoroalchilice (PFAS) - ECHA. Accessed November 19, 2024. https://echa.europa.eu/ro/hot-topics/perfluoroalkyl-chemicals-pfas Search in Google Scholar

9 Jurnalul Oficial al Uniunii Europene. Recomandarea (UE) 2022/1431 a Comisiei din 24 august 2022 privind monitorizarea substanțelor perfluoroalchilate din alimente. Accessed November 19, 2024. Available from: https://eur-lex.europa.eu/legal-content/RO/TXT/HTML/?uri=CELEX%3A32022H1431 Search in Google Scholar

10 Andersen ME, Butenhoff JL, Chang SC, et al. Perfluoroalkyl Acids and Related Chemistries—Toxicokinetics and Modes of Action. Toxicol Sci. 2008;102(1):3–14. doi:10.1093/toxsci/kfm270 Search in Google Scholar

11 Stein CR, Wolff MS, Calafat AM, Kato K, Engel SM. Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: A pilot study. Reprod Toxicol. 2012;34(3):312–316. doi:10.1016/j.reprotox.2012.05.039 Search in Google Scholar

12 Southern Research Institute. Protein Binding of Perfluorohexane Sulfonate, Perfiuorooctane Sulfonate and Perfluorooctanoate to Plasma (Human, Rat, and Monkey), and Various Human-Derived Plasma Protein Fractions. Study ID : 9921.7. Accessed November 20, 2024. Available from: https://cdn.toxicdocs.org/b5/b5GdBBdrX7baRpmeapLREKOq6/b5GdBBdrX7baRpmeapLREKOq6.pdf Search in Google Scholar

13 Zhang X, Chen L, Fei XC, Ma YS, Gao HW. Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals. BMC Mol Biol. 2009;10:16. doi:10.1186/1471-2199-10-16 Search in Google Scholar

14 Chen YM, Guo LH. Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin. Arch Toxicol. 2009;83(3):255–261. doi:10.1007/s00204-008-0359-x Search in Google Scholar

15 Weiss JM, Andersson PL, Lamoree MH, Leonards PEG, van Leeuwen SPJ, Hamers T. Competitive Binding of Poly- and Perfluorinated Compounds to the Thyroid Hormone Transport Protein Transthyretin. Toxicol Sci. 2009;109(2):206–216. doi:10.1093/toxsci/kfp055 Search in Google Scholar

16 EPA. Health Effects Support Document for Perfluorooctane Sulfonate (PFOS). Available from: https://epa.gov/sites/default/files/2016-05/documents/pfos_hesd_final_508.pdf Search in Google Scholar

17 Olsen GW, Burris JM, Ehresman DJ, et al. Half-Life of Serum Elimination of Perfluorooctanesulfonate, Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers. Environ Health Perspect. 2007;115(9):1298–1305. doi:10.1289/ehp.10009 Search in Google Scholar

18 Li Y, Fletcher T, Mucs D, et al. Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water. Occup Environ Med. 2018;75(1):46–51. doi:10.1136/oemed-2017-104651 Search in Google Scholar

19 Zhou W, Zhang L, Tong C, et al. Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women. Environ Health Perspect. 2017;125(6):067012. doi:10.1289/EHP1203 Search in Google Scholar

20 Ding N, Harlow SD, John F Randolph J, et al. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. J Clin Endocrinol Metab. 2020;105(9):e3169. doi:10.1210/clinem/dgaa303 Search in Google Scholar

21 Han X, Snow TA, Kemper RA, Jepson GW. Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem Res Toxicol. 2003;16(6):775–781. doi:10.1021/tx034005w Search in Google Scholar

22 Park SK, Peng Q, Ding N, Mukherjee B, Harlow SD. Determinants of per- and polyfluoroalkyl substances (PFAS) in midlife women: Evidence of racial/ethnic and geographic differences in PFAS exposure. Environ Res. 2019;175:186–199. doi:10.1016/j.envres.2019.05.028 Search in Google Scholar

23 Rickard BP, Rizvi I, Fenton SE. Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease. Toxicology. 2022;465:153031. doi:10.1016/j.tox.2021.153031 Search in Google Scholar

24 Sagiv SK, Rifas-Shiman SL, Webster TF, et al. Sociodemographic and Perinatal Predictors of Early Pregnancy Per- and Polyfluoroalkyl Substance (PFAS) Concentrations. Environ Sci Technol. 2015;49(19):11849. doi:10.1021/acs.est.5b02489 Search in Google Scholar

25 Fromme H, Mosch C, Morovitz M, et al. Pre- and postnatal exposure to perfluorinated compounds (PFCs). Environ Sci Technol. 2010;44(18):7123–7129. doi:10.1021/es101184f Search in Google Scholar

26 Caban-Martinez AJ, Solle NS, Feliciano PL, et al. Use of Aqueous Film-Forming Foams and Knowledge of Perfluorinated Compounds among Florida Firefighters. J Occup Environ Med. 2019;61(5):e227. doi:10.1097/JOM.0000000000001566 Search in Google Scholar

27 Freberg BI, Haug LS, Olsen R, et al. Occupational exposure to airborne perfluorinated compounds during professional ski waxing. Environ Sci Technol. 2010;44(19):7723–7728. doi:10.1021/es102033k Search in Google Scholar

28 Lundin JI, Alexander BH, Olsen GW, Church TR. Ammonium perfluorooctanoate production and occupational mortality. Epidemiol Camb Mass. 2009;20(6):921–928. doi:10.1097/EDE.0b013e3181b5f395 Search in Google Scholar

29 Heydebreck F, Tang J, Xie Z, Ebinghaus R. Emissions of Per- and Polyfluoroalkyl Substances in a Textile Manufacturing Plant in China and Their Relevance for Workers’ Exposure. Environ Sci Technol. 2016;50(19):10386–10396. doi:10.1021/acs.est.6b03213 Search in Google Scholar

30 PFAS Health Study Systematic Review_1.pdf. Accessed November 19, 2024. https://nceph.anu.edu.au/files/PFAS%20Health%20Study%20Systematic%20Review_1.pdf Search in Google Scholar

31 Panieri E, Baralic K, Djukic-Cosic D, Djordjevic AB, Saso L. PFAS Molecules: A Major Concern for the Human Health and the Environment. Toxics. 2022;10(2):44. doi:10.3390/toxics10020044 Search in Google Scholar

32 Sunderland EM, Hu XC, Dassuncao C, Tokranov AK, Wagner CC, Allen JG. A Review of the Pathways of Human Exposure to Poly- and Perfluoroalkyl Substances (PFASs) and Present Understanding of Health Effects. J Expo Sci Environ Epidemiol. 2018;29(2):131. doi:10.1038/s41370-018-0094-1 Search in Google Scholar

33 Zoeller RT, Brown TR, Doan LL, et al. Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society. Endocrinology. 2012;153(9):4097. doi:10.1210/en.2012-1422 Search in Google Scholar

34 Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1. doi:10.1210/er.2015-1010 Search in Google Scholar

35 Mattsson K, Nilsson-Condori E, Elmerstig E, et al. Fertility outcomes in women with pre-existing type 2 diabetes—a prospective cohort study. Fertil Steril. 2021;116(2):505–513. doi:10.1016/j.fertnstert.2021.02.009 Search in Google Scholar

36 Thong EP, Codner E, Laven JSE, Teede H. Diabetes: a metabolic and reproductive disorder in women. Lancet Diabetes Endocrinol. 2020;8(2):134–149. doi:10.1016/S2213-8587(19)30345-6 Search in Google Scholar

37 Ding GL, Liu Y, Liu ME, et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Asian J Androl. 2015;17(6):948. doi:10.4103/1008-682X.150844 Search in Google Scholar

38 Alexopoulos AS, Blair R, Peters AL. Management of preexisting diabetes in pregnancy: A Review. JAMA. 2019;321(18):1811. doi:10.1001/jama.2019.4981 Search in Google Scholar

39 Mulder JW, Kusters DM, Lennep JER van, Hutten BA. Lipid metabolism during pregnancy: consequences for mother and child. Curr Opin Lipidol. 2024;35(3):133. doi:10.1097/MOL.0000000000000927 Search in Google Scholar

40 Barrett ES, Chen C, Thurston SW, et al. Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women. Fertil Steril. 2015;103(5):1261–1270.e3. doi:10.1016/j.fertnstert.2015.02.001 Search in Google Scholar

41 Behr AC, Lichtenstein D, Braeuning A, Lampen A, Buhrke T. Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro. Toxicol Lett. 2018;291:51–60. doi:10.1016/j.toxlet.2018.03.029 Search in Google Scholar

42 Feng X, Wang X, Cao X, Xia Y, Zhou R, Chen L. Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation. Toxicol Sci Off J Soc Toxicol. 2015;148(2):368–379. doi:10.1093/toxsci/kfv197 Search in Google Scholar

43 Nian M, Luo K, Luo F, et al. Association between Prenatal Exposure to PFAS and Fetal Sex Hormones: Are the Short-Chain PFAS Safer? Environ Sci Technol. 2020;54(13):8291–8299. doi:10.1021/acs.est.0c02444 Search in Google Scholar

44 Rashtian J, Chavkin DE, Merhi Z. Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility. Reprod Biol Endocrinol RBE. 2019;17:5. doi:10.1186/s12958-018-0448-5 Search in Google Scholar

45 Shi Z, Zhang H, Ding L, Feng Y, Xu M, Dai J. The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats. Reprod Toxicol. 2009;27(3):352–359. doi:10.1016/j.reprotox.2009.02.008 Search in Google Scholar

46 Vélez MP, Arbuckle TE, Fraser WD. Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study. Hum Reprod Oxf Engl. 2015;30(3):701. doi:10.1093/humrep/deu350 Search in Google Scholar

47 Shen J, Mao Y, Zhang H, et al. Exposure of women undergoing in-vitro fertilization to per-and polyfluoroalkyl substances: Evidence on negative effects on fertilization and high-quality embryos. Environ Pollut. 2024;359:124474. doi:10.1016/j.envpol.2024.124474 Search in Google Scholar

48 Du G, Hu J, Huang Z, et al. Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): Advance puberty onset and kisspeptin system disturbance in female rats. Ecotoxicol Environ Saf. 2019;167:412–421. doi:10.1016/j.ecoenv.2018.10.025 Search in Google Scholar

49 Vélez MP, Arbuckle TE, Fraser WD. Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study. Hum Reprod Oxf Engl. 2015;30(3):701. doi:10.1093/humrep/deu350 Search in Google Scholar

50 Zhang S, Tan R, Pan R, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Premature Ovarian Insufficiency in Chinese Women. J Clin Endocrinol Metab. 2018;103(7):2543–2551. doi:10.1210/jc.2017-02783 Search in Google Scholar

51 Liew Z, Luo J, Nohr EA, et al. Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case–Control Study in the Danish National Birth Cohort. Environ Health Perspect. 2020;128(4):047007. doi:10.1289/EHP6202 Search in Google Scholar

52 Blake BE, Fenton SE. Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects. Toxicology. 2020;443:152565. doi:10.1016/j.tox.2020.152565 Search in Google Scholar

53 Zhang N, Wang WS, Li WJ, Liu C, Wang Y, Sun K. Reduction of progesterone, estradiol and hCG secretion by perfluorooctane sulfonate via induction of apoptosis in human placental syncytiotrophoblasts. Placenta. 2015;36(5):575–580. doi:10.1016/j.placenta.2015.02.008 Search in Google Scholar

54 Everson TM, Sehgal N, Barr DB, et al. Placental PFAS concentrations are associated with perturbations of placental DNA methylation at loci with important roles on cardiometabolic health. medRxiv. Published online May 7, 2024:2024.05.06.24306905. doi:10.1101/2024.05.06.24306905 Search in Google Scholar

55 Groisman L, Berman T, Quinn A, et al. Levels of PFAS concentrations in the placenta and pregnancy complications. Ecotoxicol Environ Saf. 2023;262:115165. doi:10.1016/j.ecoenv.2023.115165 Search in Google Scholar

56 Aimuzi R, Luo K, Huang R, et al. Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy. Environ Pollut. 2020;264:114557. doi:10.1016/j.envpol.2020.114557 Search in Google Scholar

57 Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK. Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort. Environ Pollut. 2018;242:894–904. doi:10.1016/j.envpol.2018.07.042 Search in Google Scholar

58 Singh R. Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS). Toxicology. Published online January 1, 2008. Accessed November 19, 2024. Available from: https://www.academia.edu/14796429/Thyroid_hormone_status_and_pituitary_function_in_adult_rats_given_oral_doses_of_perfluorooctanesulfonate_PFOS_ Search in Google Scholar

59 Fenton SE, Ducatman A, Boobis A, et al. Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research. Environ Toxicol Chem. 2021;40(3):606–630. doi:10.1002/etc.4890 Search in Google Scholar

60 Jain RB. Association between thyroid profile and perfluoroalkyl acids: Data from NHNAES 2007–2008. Environ Res. 2013;126:51–59. doi:10.1016/j.envres.2013.08.006 Search in Google Scholar

61 Lau C, Thibodeaux JR, Hanson RG, et al. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol Sci Off J Soc Toxicol. 2003;74(2):382–392. doi:10.1093/toxsci/kfg122 Search in Google Scholar

62 Lewis RC, Johns LE, Meeker JD. Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012. Int J Environ Res Public Health. 2015;12(6):6098–6114. doi:10.3390/ijerph120606098 Search in Google Scholar

63 Wang Y, Rogan WJ, Chen PC, et al. Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study. Environ Health Perspect. 2014;122(5):529–534. doi:10.1289/ehp.1306925 Search in Google Scholar

64 Herwig A, Campbell G, Mayer CD, et al. A thyroid hormone challenge in hypothyroid rats identifies T3 regulated genes in the hypothalamus and in models with altered energy balance and glucose homeostasis. Thyroid Off J Am Thyroid Assoc. 2014;24(11):1575–1593. doi:10.1089/thy.2014.0169 Search in Google Scholar

65 Zhang C, Guo L, Zhu B, et al. Effects of 3, 5, 3’-triiodothyronine (t3) and follicle stimulating hormone on apoptosis and proliferation of rat ovarian granulosa cells. Chin J Physiol. 2013;56(5):298–305. doi:10.4077/CJP.2013.BAB186 Search in Google Scholar

66 Kirkland JL, Gardner RM, Mukku VR, Akhtar M, Stancel GM. Hormonal control of uterine growth: the effect of hypothyroidism on estrogen-stimulated cell division. Endocrinology. 1981;108(6):2346–2351. doi:10.1210/endo-108-6-2346 Search in Google Scholar

67 Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol (Oxf). 2007;66(3):309–321. doi:10.1111/j.1365-2265.2007.02752.x Search in Google Scholar

68 Shi W, Zhang Z, Li M, Dong H, Li J. Reproductive toxicity of PFOA, PFOS and their substitutes: A review based on epidemiological and toxicological evidence. Environ Res. 2024;250:118485. doi:10.1016/j.envres.2024.118485 Search in Google Scholar

69 Di Nisio A, Sabovic I, Valente U, et al. Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence. J Clin Endocrinol Metab. 2019;104(4):1259–1271. doi:10.1210/jc.2018-01855 Search in Google Scholar

70 Timmermann CAG, Budtz-Jørgensen E, Petersen MS, et al. Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances. Reprod Toxicol. 2017;68:164–170. doi:10.1016/j.reprotox.2016.07.010 Search in Google Scholar

71 Rosen EM, Brantsæter AL, Carroll R, et al. Maternal Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Breastfeeding Duration in the Norwegian Mother and Child Cohort. Environ Epidemiol Phila Pa. 2018;2(3):e027. doi:10.1097/EE9.0000000000000027 Search in Google Scholar

72 Mamsen LS, Björvang RD, Mucs D, et al. Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies. Environ Int. 2019;124:482–492. doi:10.1016/j.envint.2019.01.010 Search in Google Scholar

73 Varsi K, Torsvik IK, Huber S, Averina M, Brox J, Bjørke-Monsen AL. Impaired gross motor development in infants with higher PFAS concentrations. Environ Res. 2022;204:112392. doi:10.1016/j.envres.2021.112392 Search in Google Scholar

74 Fei C, McLaughlin JK, Tarone RE, Olsen J. Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth Cohort. Environ Health Perspect. 2007;115(11):1677–1682. doi:10.1289/ehp.10506 Search in Google Scholar

75 Zheng T, Kelsey K, Zhu C, et al. Adverse birth outcomes related to concentrations of per- and polyfluoroalkyl substances (PFAS) in maternal blood collected from pregnant women in 1960–1966. Environ Res. 2024;241:117010. doi:10.1016/j.envres.2023.117010 Search in Google Scholar

76 Assessment UENC for E. Birth outcomes in relation to prenatal exposure to per- and polyfluoroalkyl substances and stress in the environmental influences on child health outcomes (echo) program. March 15, 2009. Accessed November 19, 2024. https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/10893257 Search in Google Scholar

77 Lamichhane S, Siljander H, Duberg D, et al. Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk. Environ Int. 2021;157:106855. doi:10.1016/j.envint.2021.106855 Search in Google Scholar

78 Varsi K, Torsvik IK, Huber S, Averina M, Brox J, Bjørke-Monsen AL. Impaired gross motor development in infants with higher PFAS concentrations. Environ Res. 2022;204:112392. doi:10.1016/j.envres.2021.112392 Search in Google Scholar

79 Varsi K, Torsvik IK, Huber S, Averina M, Brox J, Bjørke-Monsen AL. Impaired gross motor development in infants with higher PFAS concentrations. Environ Res. 2022;204:112392. doi:10.1016/j.envres.2021.112392 Search in Google Scholar

80 Frangione B, Birk S, Benzouak T, et al. Exposure to perfluoroalkyl and polyfluoroalkyl substances and pediatric obesity: a systematic review and meta-analysis. Int J Obes 2005. 2024;48(2):131–146. doi:10.1038/s41366-023-01401-6 Search in Google Scholar

81 Geiger SD, Yao P, Vaughn MG, Qian Z. PFAS exposure and overweight/obesity among children in a nationally representative sample. Chemosphere. 2021;268:128852. doi:10.1016/j.chemosphere.2020.128852 Search in Google Scholar

82 Lauritzen HB, Larose TL, Øien T, et al. Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study. Environ Health. 2018;17:9. doi:10.1186/s12940-017-0338-x Search in Google Scholar

83 Beck IH, Bilenberg N, Möller S, et al. Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort. Am J Epidemiol. 2023;192(9):1522–1535. doi:10.1093/aje/kwad110 Search in Google Scholar

84 Spratlen MJ, Perera FP, Lederman SA, et al. The association between prenatal exposure to perfluoroalkyl substances and childhood neurodevelopment. Environ Pollut. 2020;263:114444. doi:10.1016/j.envpol.2020.114444 Search in Google Scholar

85 Ernst A, Brix N, Lauridsen LLB, et al. Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort. Environ Health Perspect. 2019;127(1):017004. doi:10.1289/EHP3567 Search in Google Scholar

86 Kristensen SL, Ramlau-Hansen CH, Ernst E, et al. Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction. Hum Reprod Oxf Engl. 2013;28(12):3337–3348. doi:10.1093/humrep/det382 Search in Google Scholar

87 Lopez-Espinosa MJ, Fletcher T, Armstrong B, et al. Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant. Environ Sci Technol. 2011;45(19):8160–8166. doi:10.1021/es1038694 Search in Google Scholar

88 Marks KJ, Howards PP, Smarr MM, et al. Prenatal exposure to mixtures of persistent endocrine disrupting chemicals and early menarche in a population-based cohort of British girls. Environ Pollut. 2021;276:116705. doi:10.1016/j.envpol.2021.116705 Search in Google Scholar

89 Zahm S, Bonde JP, Chiu WA, et al. Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid. Lancet Oncol. 2024;25(1):16–17. doi:10.1016/S1470-2045(23)00622-8 Search in Google Scholar

90 Jones RR, Madrigal JM, Troisi R, et al. Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia. J Natl Cancer Inst. 2024;116(5):728–736. doi:10.1093/jnci/djad261 Search in Google Scholar

91 Hærvig KK, Petersen KU, Hougaard KS, et al. Maternal Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Male Reproductive Function in Young Adulthood: Combined Exposure to Seven PFAS. Environ Health Perspect. 2022;130(10):107001. doi:10.1289/EHP10285 Search in Google Scholar

92 Cohn BA, La Merrill MA, Krigbaum NY, et al. In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer. Reprod Toxicol. 2020;92:112–119. doi:10.1016/j.reprotox.2019.06.012 Search in Google Scholar

93 Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK. Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort. Environ Pollut. 2018;242:894–904. doi:10.1016/j.envpol.2018.07.042 Search in Google Scholar

94 Cardenas A, Hauser R, Gold DR, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. JAMA Netw Open. 2018;1(4):e181493. doi:10.1001/jamanetworkopen.2018.1493 Search in Google Scholar

95 Hölzer J, Midasch O, Rauchfuss K, et al. Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate-Contaminated Drinking Water. Environ Health Perspect. 2008;116(5):651–657. doi:10.1289/ehp.11064 Search in Google Scholar

96 Ding N, Karvonen-Gutierrez CA, Herman WH, Calafat AM, Mukherjee B, Park SK. Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women. Int J Hyg Environ Health. 2021;235:113777. doi:10.1016/j.ijheh.2021.113777 Search in Google Scholar

97 Wu B, Pan Y, Li Z, et al. Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study. Environ Int. 2023;172:107779. doi:10.1016/j.envint.2023.107779 Search in Google Scholar

98 Chen Z, Yang T, Walker DI, et al. Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults. Environ Int. 2020;145:106091. doi:10.1016/j.envint.2020.106091 Search in Google Scholar

99 Jiang L, Liu Y, Zhou Y, et al. Targeted metabolomics unravels altered phenylalanine levels in piglets receiving total parenteral nutrition. FASEB J Off Publ Fed Am Soc Exp Biol. 2023;37(7):e23014. doi:10.1096/fj.202300261RR Search in Google Scholar

100 Rotander A, Ramos MJG, Mueller JF, Toms LM, Hyötyläinen T. Metabolic changes associated with PFAS exposure in firefighters: A pilot study. Sci Total Environ. 2024;953:176004. doi:10.1016/j.scitotenv.2024.176004 Search in Google Scholar

101 Lundin JI, Alexander BH, Olsen GW, Church TR. Ammonium Perfluorooctanoate Production and Occupational Mortality. Epidemiology. 2009;20(6):921. doi:10.1097/EDE.0b013e3181b5f395 Search in Google Scholar

102 Leonard RC, Kreckmann KH, Sakr CJ, Symons JM. Retrospective Cohort Mortality Study of Workers in a Polymer Production Plant Including a Reference Population of Regional Workers. Ann Epidemiol. 2008;18(1):15–22. doi:10.1016/j.annepidem.2007.06.011 Search in Google Scholar

103 Cardenas A, Hivert MF, Gold DR, et al. Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Incident Diabetes and Microvascular Disease. Diabetes Care. 2019;42(9):1824–1832. doi:10.2337/dc18-2254 Search in Google Scholar

104 Domazet SL, Grøntved A, Timmermann AG, Nielsen F, Jensen TK. Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study. Diabetes Care. 2016;39(10):1745–1751. doi:10.2337/dc16-0269 Search in Google Scholar

105 Meyer JD, McDiarmid M, Diaz JH, Baker BA, Hieb M, Toxicology ATF on R. Reproductive and Developmental Hazard Management. J Occup Environ Med. 2016;58(3):e94. doi:10.1097/JOM.0000000000000669 Search in Google Scholar