Predictors of survival and functioning of arteriovenous fistula in patients on hemodialysis during a one-year follow-up

Differences in sociodemographic and clinical characteristics of patients

Variables		All patients	Survive	Exitus	p-value
		(N=120)	(N=101)	(N=19)
Age		66.0 (59.0–71.8)	66.0 (59.0–71.0)	68.0 (51.0–70.0)	0.863
Gender N (%)	male	70(58)	57 (56.4)	13 (68.4)	0.448
	female	50(42)	44 (43.6)	6 (31.6)
AVF positioning N (%)	distal	46(38)	43 (42.6)	3 (15.8)	0.038*
	proximal	74(62)	58 (57.4)	16 (84.2)
	AVF	97(81)	89 (88.2)	8 (42.1)
Type of VA N (%)	AVG	1(1)	1 (0.9)	0 (0)	0.001*
	Hickman catheter	22(18)	11 (10.9)	11 (57.9)
Length of HD (months)		51.0 (29.0–82.8)	56.0 (32.5–85.0)	14.0 (6.0–43.0)	0.001*
Type HD N (%)	bicarbonate	101(84)	85 (84.2)	16 (84.2)	1.000
	hemodiafiltration	19(16)	16 (15.8)	3 (15.8)
SBP (mmHg)		30.0 (120.0–140.0)	130.0 (120.0–140.0)	120.0 (120.0–140.0)	0.701
DBP (mmHg)		80.0 (70.0–80.0)	80.0 (70.0–80.0)	80.00 (70.0–80.0)	0.409
BMI (kg/m2)		24.8 (22.0–27.5)	24.3 (21.9–27.5)	25.3 (23.5–27.4)	0.361
WBC		6.4 (5.4–8.0)	6.2 (5.4–7.9)	7.2 (5.4–8.5)	0.411
HGB		104.0 (96.3–110.8)	105.0 (97.5–112.5)	97.0 (84.0–104.0)	0.008*
PLT		94.5 (154.3–244.0)	191.0 (153.0–237.0)	225.0 (158.0–280.0)	0.146
Urea		19.7 (17.6–22.8)	19.6 (17.7–22.8)	19.7 (17.5–23.0)	0.776
Creatinine		799.5 (683.3–914.0)	822.0 (687.5–940.5)	704.0 (637.0–811.0)	0.042*
Kt/V		1.1 (0.9–1.2)	1.1 (1.0–1.2)	0.9 (0.7–1.2)	0.010*
Albumin		40.0 (38.0–42.0)	40.0 (38.0–42.0)	39.0 (34.0–42.0)	0.366
Prealbumin		0.3 (0.3–0.4)	0.3 (0.3–0.4)	0.3 (0.3–0.4)	0.729
Na		139.0 (137.0–140.3)	139.0 (138.5–140.5)	137.0 (136.0–141.0)	0.404
K		5.3 (4.7–5.7)	5.3 (4.8–5.7)	4.9 (4.4–5.6)	0.142
Ca		2.3 (2.2–2.4)	2.3 (2.2–2.4)	2.2 (2.1–2.4)	0.212
P		1.5 (1.2–1.8)	1.5 (1.2–1.8)	1.6 (1.2–2.0)	0.527
CRP		4.1 (1.9–7.6)	4.2 (1.9–7.6)	2.9 (2.2–14.1)	0.404
β microglobulin		22.9 (19.2–28.3)	22.9 (19.4–27.6)	23.1 (12.6–33.5)	0.746
IL-6		7.7 (4.6–18.3)	7.3 (4.6–17.1)	13.7 (6.9–33.7)	0.163
Who created AVF	nephrologist	29(24)	25 (24.8)	4 (21.1)	1.000
	vascular surgeon	91(76)	76 (75.2)	15 (78.9)

Results of univariable and multivariable regression of predictors of length of functional vascular access in hemodialysis patients who survived during one-year follow-up

Variables	Univariable analysis		Multivariable analysis
	B (95% C.I. for B)	p-value	B (95% C.I. for B)	p-value
Age	0.07 (−0.90;1.04)	0.888
Gender	−1.76 (−22.23;18.71)	0.865
AVF positioning	−11.95 (−32.35;8.43)	0.247
Type of vascular access	−13.27 (−29.24;2.68)	0.102
Length of HD (months)	−0.58 (0.47;0.69)	0.001*	−0.29 (0.14;0.44)	0.001*
Type HD	23.94 (−3.458;51.33)	0.086
SBP (mmHg)	−0.34 (−0.95;0.27)	0.269
DBP mmHg)	−1.48 (−2.80;–0.13)	0.032*	0.30 (−1.08;1.68)	0.662
BMI (kg/m2)	−1.34 (−3.66;0.98)	0.254
WBC	−4.96 (−8.77;–1.15)	0.011*	−0.62 (−4.19;2.94)	0.727
HGB	1.06 (0.23;1.90)	0.013*	−0.17 (−0.93;0.59)	0.654
PLT	−0.22 (−0.37;–0.07)	0.005*	−0.09 (−0.23;0.05)	0.197
Urea	−1.30 (−3.25;0.64)	0.186
Creatinine	0.02 (−0.03;0.07)	0.357
Kt/V	20.92 (−23.70;65.54)	0.355
Albumin	−1.45 (−4.53;1.63)	0.352
Prealbumin	−51.93 (−180.21;76.34)	0.421
Na	−3.31 (−14.95;8.34)	0.554
K	−2.99 (−17.10;11.12)	0.674
Ca	40.87 (−18.27;100.02)	0.172
P	0.16 (−22.94;22.98)	0.999
CRP	−0.31 (−0.90;0.29)	0.304
β microglobulin	0.10 (−0.19;0.39)	0.505
IL-6	0.02 (−0,04; 0.08)	0.514
Who created AVF	−26.24 (−49.03;–3.45)	0.024*	−23.16 (−42.72; −3.60)	0.021*
Did you start HD with CVK	25.42 (5.85;44.98)	0.011*	7.72 (−9.97;25.72)	0.381

Results of univariable and multivariable regression of predictors of survival

Variables	B	Exp(B)	95% C.I.for EXP(B)		p-value	B	Exp(B)	95% C.I.for EXP(B)		p-value
			Lower	Upper				Lower	Upper
Age	0.009	1.009	0.963	1.057	0.712
Gender	0.514	1.673	0.589	4.752	0.334
AVF positioning	1.375	3.954	1.083	14.431	0.037*	−0.283	0.754	0.133	4.269	0.749
Type of VA	1.202	3.327	1.911	5.791	0.001*	0.511	1.667	0.776	3.578	0.190
Length of HD (months)	−0.041	0.960	0.936	0.984	0.001*	−0.035	0.966	0.936	0.996	0.028*
Type HD	−0.004	0.996	0.260	3.819	0.995
SBP (mmHg)	−0.005	0.995	0.966	1.025	0.744
DBP (mmHg)	−0.020	0.980	0.918	1.047	0.552
BMI (kg/m2)	0.048	1.050	0.940	1.171	0.389
WBC	0.073	1.076	0.890	1.301	0.450
HGB	−0.050	0.951	0.913	0.991	0.016*	−0.026	0.975	0.912	1.095	0.312
PLT	0.004	1.006	0.999	1.013	0.115
Urea	−0.027	0.973	0.863	1.098	0.661
Creatinine	−0.003	0.997	0.994	1.000	0.030*	−1.342	0.261	0.927	1.024	0.540
Kt/V	−2.209	0.110	0.012	0.997	0.050*	−0.950	0,387	0.035	4.278	0.438
Albumin	−0.078	0.925	0.803	1.066	0.280
Prealbumin	−1.802	0.165	0.001	478.284	0.658
Na	−0.210	0.811	0.517	1.271	0.360
K	−0.702	0.495	0.203	1.207	0.122
Ca	−1.497	0.224	0.007	7.018	0.394
P	0.200	1.221	0.339	4.392	0.760
CRP	0.016	1.016	0.993	1.039	0.169
β microglobulin	−0.004	0.996	0.970	1.023	0.777
IL-6	−0.001	0.999	0.994	1.005	0.790
Who created AVF	0.210	1.234	0.375	4.063	0.730
Did you start HD with CVC	−0.360	0.697	0.254	1.917	0.484