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A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Petr Jabandziev

Petr Jabandziev

  • Department of Pediatrics, University Hospital BrnoBrno, Czech Republic
  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Central European Institute of TechnologyBrno, Czech Republic
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Jabandziev, Petr
, 
Jaroslav Alois Hubacek

Jaroslav Alois Hubacek

  • Experimental Medicine Centre, Institute for Clinical and Experimental MedicinePrague, Czech Republic
  • Third Department of Internal Medicine, First Faculty of Medicine, Charles UniversityPrague, Czech Republic
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Hubacek, Jaroslav Alois
, 
Jaroslav Michalek

Jaroslav Michalek

Department of Quantitative Methods, University of DefenceBrno, Czech Republic
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Michalek, Jaroslav
, 
Martin Jouza

Martin Jouza

  • Department of Pediatrics, University Hospital BrnoBrno, Czech Republic
  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Jouza, Martin
, 
Jan Papez

Jan Papez

  • Department of Pediatrics, University Hospital BrnoBrno, Czech Republic
  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Papez, Jan
, 
Jakub Pecl

Jakub Pecl

  • Department of Pediatrics, University Hospital BrnoBrno, Czech Republic
  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Pecl, Jakub
, 
Katerina Slaba

Katerina Slaba

  • Department of Pediatrics, University Hospital BrnoBrno, Czech Republic
  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Slaba, Katerina
, 
Ondrej Slaby

Ondrej Slaby

  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Central European Institute of TechnologyBrno, Czech Republic
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Slaby, Ondrej
, 
Milan Urik

Milan Urik

Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Urik, Milan
, 
Stefania Aulicka

Stefania Aulicka

Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
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Aulicka, Stefania
, 
Lumir Kunovsky

Lumir Kunovsky

  • Department of Gastroenterology and Internal Medicine, University Hospital BrnoBrno, Czech Republic
  • Department of Surgery, University Hospital BrnoBrno, Czech Republic
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Kunovsky, Lumir
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Jaroslav Michalek

Jaroslav Michalek

Cellthera LtdBrno, Czech Republic
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Michalek, Jaroslav
, 
Petr Dominik

Petr Dominik

  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital BrnoBrno, Czech Republic
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Dominik, Petr
, 
Milan Kratochvil

Milan Kratochvil

  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital BrnoBrno, Czech Republic
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Kratochvil, Milan
, 
Jozef Klucka

Jozef Klucka

  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital BrnoBrno, Czech Republic
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Klucka, Jozef
 and 
Petr Stourac

Petr Stourac

  • Faculty of Medicine, Masaryk UniversityBrno, Czech Republic
  • Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital BrnoBrno, Czech Republic
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Stourac, Petr
  
Mar 12, 2024
A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children's Cover Image
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Published Online: Mar 12, 2024
Page range: 279 - 285
Received: Oct 23, 2024
DOI: https://doi.org/10.2478/rjim-2024-0008
Keywords
© 2024 Petr Jabandziev et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction

Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents.

Methods

We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0–19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults.

Results

We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39–0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62–1.06).

Conclusions

Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Internal Medicine, other, Cardiology, Gastroenterology, Rheumatology
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