Perioperative trajectory of haemoglobin, predictors of blood transfusion and tailoring targets for patient blood management interventions: A single-centre, retrospective study of non-emergent cardiac surgery patients

[1]Scolletta S, Simioni P, Campagnolo V, Celiento M, Fontanari P, Guadagnucci A, et al. Patient blood management in cardiac surgery: The “Granducato algorithm.” Int J Cardiol. 2019;289: 37–42. Scolletta S Simioni P Campagnolo V Celiento M Fontanari P Guadagnucci A et al Patient blood management in cardiac surgery: The “Granducato algorithm ” Int J Cardiol 2019289 37 4210.1016/j.ijcard.2019.01.02530711263Search in Google Scholar

[2]Dhir A, Tempe DK. Anemia and Patient Blood Management in Cardiac Surgery—Literature Review and Current Evidence. J Cardiothorac Vasc Anesth. 2017;32(6):2726–42. Dhir A Tempe DK Anemia and Patient Blood Management in Cardiac Surgery—Literature Review and Current Evidence J Cardiothorac Vasc Anesth 20173262726 4210.1053/j.jvca.2017.11.04329307702Search in Google Scholar

[3]Blaudszun G, Butchart A, Klein AA. Blood conservation in cardiac surgery. Transfus Med. 2017;28(2):168–80. Blaudszun G Butchart A Klein AA Blood conservation in cardiac surgery Transfus Med 2017282168 8010.1111/tme.1247528940923Search in Google Scholar

[4]Beattie WS, Karkouti K, Wijeysundera DN, Tait G. Risk Associated with Preoperative Anemia in Noncardiac SurgeryA Single-center Cohort Study. Anesthesiol J Am Soc Anesthesiol. 2009;110(3):574–81. Beattie WS Karkouti K Wijeysundera DN Tait G Risk Associated with Preoperative Anemia in Noncardiac SurgeryA Single-center Cohort Study Anesthesiol J Am Soc Anesthesiol 20091103574 81Search in Google Scholar

[5]Baron DM, Hochrieser H, Posch M, Metnitz B, Rhodes A, Moreno RP, et al. Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients. Br J Anaesth. 2014;113(3):416–23. Baron DM Hochrieser H Posch M Metnitz B Rhodes A Moreno RP et al Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients Br J Anaesth 20141133416 2310.1093/bja/aeu09824829444Search in Google Scholar

[6]Musallam KM, Tamim HM, Richards T, Spahn DR, Rosendaal FR, Habbal A, et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. The Lancet. 2011;378(9800):1396–407. Musallam KM Tamim HM Richards T Spahn DR Rosendaal FR Habbal A et al Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study The Lancet 201137898001396 40710.1016/S0140-6736(11)61381-021982521Search in Google Scholar

[7]Klein AA, Collier TJ, Brar MS, Evans C, Hallward G, Fletcher SN, et al. The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit. Anaesthesia. 2016;71(6):627–35. Klein AA Collier TJ Brar MS Evans C Hallward G Fletcher SN et al The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK - the first Association of Cardiothoracic Anaesthetists national audit Anaesthesia 2016716627 3510.1111/anae.1342326993159Search in Google Scholar

[8]McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12(04):444. McLean E Cogswell M Egli I Wojdyla D de Benoist B Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005 Public Health Nutr 2009120444410.1017/S136898000800240118498676Search in Google Scholar

[9]Hogan M, Klein AA, Richards T. The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery. Eur J Cardiothorac Surg. 2015;47(2):218–26. Hogan M Klein AA Richards T The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery Eur J Cardiothorac Surg 2015472218 2610.1093/ejcts/ezu20024824650Search in Google Scholar

[10]Murphy GJ, Reeves BC, Rogers CA, Rizvi SIA, Culliford L, Angelini GD. Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery. Circulation. 2007 27;116(22):2544–52. Murphy GJ Reeves BC Rogers CA Rizvi SIA Culliford L Angelini GD Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery Circulation 2007 27 116222544 5210.1161/CIRCULATIONAHA.107.69897717998460Search in Google Scholar

[11]Ming Y, Liu J, Zhang F, Chen C, Zhou L, Du L, et al. Transfusion of Red Blood Cells, Fresh Frozen Plasma, or Platelets Is Associated With Mortality and Infection After Cardiac Surgery in a Dose-Dependent Manner: Anesth Analg. 2020;130(2):488– 97. Ming Y Liu J Zhang F Chen C Zhou L Du L et al Transfusion of Red Blood Cells, Fresh Frozen Plasma, or Platelets Is Associated With Mortality and Infection After Cardiac Surgery in a Dose-Dependent Manner Anesth Analg 20201302488–97Search in Google Scholar

[12]Vlot EA, Verwijmeren L, van de Garde EMW, Kloppenburg GTL, van Dongen EPA, Noordzij PG. Intra-operative red blood cell transfusion and mortality after cardiac surgery. BMC Anesthesiol. 2019;19(1):65. Vlot EA Verwijmeren L van de Garde EMW Kloppenburg GTL van Dongen EPA Noordzij PG Intra-operative red blood cell transfusion and mortality after cardiac surgery BMC Anesthesiol 20191916510.1186/s12871-019-0738-2649994731054585Search in Google Scholar

[13]Mariscalco G, Biancari F, Juvonen T, Zanobini M, Cottini M, Banach M, et al. Red blood cell transfusion is a determinant of neurological complications after cardiac surgery. Interact Cardiovasc Thorac Surg. 2015;20(2):166–71. Mariscalco G Biancari F Juvonen T Zanobini M Cottini M Banach M et al Red blood cell transfusion is a determinant of neurological complications after cardiac surgery Interact Cardiovasc Thorac Surg 2015202166 7110.1093/icvts/ivu36025368133Search in Google Scholar

[14]Loor G, Rajeswaran J, Li L, Sabik JF, Blackstone EH, McCrae KR, et al. The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both? J Thorac Cardiovasc Surg. 2013;146(6):1480-1487.e6. Loor G Rajeswaran J Li L Sabik JF Blackstone EH McCrae KR et al The least of 3 evils: Exposure to red blood cell transfusion, anemia, or both? J Thorac Cardiovasc Surg 201314661480 1487 e610.1016/j.jtcvs.2013.06.03323998782Search in Google Scholar

[15]Klein AA, Chau M, Yeates JA, Collier T, Evans C, Agarwal S, et al. Preoperative intravenous iron before cardiac surgery: a prospective multicentre feasibility study. Br J Anaesth. 2020;124(3):243–50. Klein AA Chau M Yeates JA Collier T Evans C Agarwal S et al Preoperative intravenous iron before cardiac surgery: a prospective multicentre feasibility study Br J Anaesth 20201243243 5010.1016/j.bja.2019.11.02331902590Search in Google Scholar

[16]Spahn DR, Schoenrath F, Spahn GH, Seifert B, Stein P, Theusinger OM, et al. Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial. The Lancet. 2019;393(10187):2201–12. Spahn DR Schoenrath F Spahn GH Seifert B Stein P Theusinger OM et al Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial The Lancet 2019393101872201 1210.1016/S0140-6736(18)32555-831036337Search in Google Scholar

[17]Blaudszun G, Munting KE, Butchart A, Gerrard C, Klein AA. The association between borderline pre-operative anaemia in women and outcomes after cardiac surgery: a cohort study. Anaesthesia. 2018;73(5):572–8. Blaudszun G Munting KE Butchart A Gerrard C Klein AA The association between borderline pre-operative anaemia in women and outcomes after cardiac surgery: a cohort study Anaesthesia 2018735572 810.1111/anae.1418529349775Search in Google Scholar

[18]Muñoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the perioperative management of anaemia and iron deficiency. Anaesthesia. 2017;72(2):233–47. Muñoz M Acheson AG Auerbach M Besser M Habler O Kehlet H et al International consensus statement on the perioperative management of anaemia and iron deficiency Anaesthesia 2017722233 4710.1111/anae.1377327996086Search in Google Scholar

[19]Gómez-Ramírez S, Bisbe E, Shander A, Spahn DR, Muñoz M. Management of Perioperative Iron Deficiency Anemia. Acta Haematol. 2019;142(1):21–9. Gómez-Ramírez S Bisbe E Shander A Spahn DR Muñoz M Management of Perioperative Iron Deficiency Anemia Acta Haematol 2019142121 910.1159/00049696530970362Search in Google Scholar

[20]Filipescu D, Banateanu R, Beuran M, Burcos T, Corneci D, Cristian D, et al. Perioperative Patient Blood Management Programme. Multidisciplinary recommendations from the Patient Blood Management Initiative Group. Romanian J Anaesth Intensive Care. 2017;24(2):139–57. Filipescu D Banateanu R Beuran M Burcos T Corneci D Cristian D et al Perioperative Patient Blood Management Programme Multidisciplinary recommendations from the Patient Blood Management Initiative Group. Romanian J Anaesth Intensive Care 2017242139 57Search in Google Scholar

[21]ORDIN nr. 1.251 din 28 septembrie 2018 pentru aprobarea Ghidului de gestionare a sângelui pacientului în perioada perioperatorie. Monitorul Oficial al României nr 877; 2018. ORDIN nr 1.251 din 28 septembrie 2018 pentru aprobarea Ghidului de gestionare a sângelui pacientului în perioada perioperatorie Monitorul Oficial al României nr 877 2018Search in Google Scholar

[22]Ristescu I, Pintilie G, Filip D, Jitca M, Fecheta R, Florescu I, et al. Perioperative Anemia and Transfusion in Colorectal Cancer Patients. Chirurgia (Bucur). 2019;114(2):234. Ristescu I Pintilie G Filip D Jitca M Fecheta R Florescu I et al Perioperative Anemia and Transfusion in Colorectal Cancer Patients Chirurgia (Bucur) 2019114223410.21614/chirurgia.114.2.23431060656Search in Google Scholar

[23]Delaforce A, Duff J, Munday J, Hardy J. Overcoming barriers to evidence-based patient blood management: a restricted review. Implement Sci. 2020;15(1):6. Delaforce A Duff J Munday J Hardy J Overcoming barriers to evidence-based patient blood management: a restricted review Implement Sci 2020151610.1186/s13012-020-0965-4696947931952514Search in Google Scholar

[24]Rancati V, Scala E, Ltaief Z, Gunga MZ, Kirsch M, Rosner L, et al. Challenges in Patient Blood Management for Cardiac Surgery: A Narrative Review. J Clin Med. 2021;10(11):2454. Rancati V Scala E Ltaief Z Gunga MZ Kirsch M Rosner L et al Challenges in Patient Blood Management for Cardiac Surgery: A Narrative Review J Clin Med 20211011245410.3390/jcm10112454819848334205971Search in Google Scholar

[25]Hofmann A, Spahn DR, Holtorf A-P, PBM Implementation Group, Isbister J, Hamdorf J, et al. Making patient blood management the new norm(al) as experienced by implementors in diverse countries. BMC Health Serv Res. 2021;21(1):634. Hofmann A Spahn DR Holtorf A-P PBM Implementation Group Isbister J Hamdorf J et al Making patient blood management the new norm(al) as experienced by implementors in diverse countries BMC Health Serv Res 202121163410.1186/s12913-021-06484-3824943934215251Search in Google Scholar

[26]Ranucci M, Conti D, Castelvecchio S, Menicanti L, Frigiola A, Ballotta A, et al. Hematocrit on cardiopulmonary bypass and outcome after coronary surgery in nontransfused patients. Ann Thorac Surg. 2010;89(1):11–7. Ranucci M Conti D Castelvecchio S Menicanti L Frigiola A Ballotta A et al Hematocrit on cardiopulmonary bypass and outcome after coronary surgery in nontransfused patients Ann Thorac Surg 201089111 710.1016/j.athoracsur.2009.07.07820103197Search in Google Scholar

[27]Chant C, Wilson G, Friedrich JO. Anemia, transfusion, and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study. Crit Care. 2006;10(5):R140. Chant C Wilson G Friedrich JO Anemia, transfusion, and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study Crit Care 2006105R14010.1186/cc5054175107517002795Search in Google Scholar

[28]Bodley T, Chan M, Levi O, Clarfield L, Yip D, Smith O, et al. Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study. Serra R, editor. PLOS ONE. 2021;16(1):e0243782. Bodley T Chan M Levi O Clarfield L Yip D Smith O et al Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study Serra R, editor. PLOS ONE 2021161e024378210.1371/journal.pone.0243782780615133439871Search in Google Scholar

[29]Kim C, Connell H, McGeorge A, Hu R. Prevalence of preoperative anaemia in patients having first-time cardiac surgery and its impact on clinical outcome. A retrospective observational study. Perfusion. 2015;30(4):277–83. Kim C Connell H McGeorge A Hu R Prevalence of preoperative anaemia in patients having first-time cardiac surgery and its impact on clinical outcome A retrospective observational study. Perfusion 2015304277 8310.1177/026765911454245724996406Search in Google Scholar

[30]Boer C, Meesters MI, Milojevic M, Benedetto U, Bolliger D, von Heymann C, et al. 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery. J Cardiothorac Vasc Anesth. 2018;32(1):88–120. Boer C Meesters MI Milojevic M Benedetto U Bolliger D von Heymann C et al 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery J Cardiothorac Vasc Anesth 201832188 12010.1053/j.jvca.2017.06.02629029990Search in Google Scholar

[31]Loor G, Li L, Sabik JF 3rd, Rajeswaran J, Blackstone EH, Koch CG. Nadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality. J Thorac Cardiovasc Surg. 2012 Sep;144(3):654-662.e4. Loor G Li L Sabik JF 3rd Rajeswaran J Blackstone EH Koch CG Nadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality J Thorac Cardiovasc Surg 2012 Sep1443654 662 e4.10.1016/j.jtcvs.2012.03.05822507841Search in Google Scholar

[32]Mazer CD, Whitlock RP, Fergusson DA, Belley-Cote E, Connolly K, Khanykin B, et al. Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery. N Engl J Med. 2018;379(13):1224–33. Mazer CD Whitlock RP Fergusson DA Belley-Cote E Connolly K Khanykin B et al Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery N Engl J Med 2018379131224 3310.1056/NEJMoa180856130146969Search in Google Scholar

[33]Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, et al. Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis. Br J Anaesth. 2021;126(1):149–56. Roman MA Abbasciano RG Pathak S Oo S Yusoff S Wozniak M et al Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis Br J Anaesth 20211261149 5610.1016/j.bja.2020.04.087784434832620259Search in Google Scholar

[34]Cataife G, Pagano MB. How much does a blood transfusion cost?: EDITORIAL. Transfusion (Paris). 2018 Apr;58(4):833–5. Cataife G Pagano MB How much does a blood transfusion cost?: EDITORIAL Transfusion (Paris) 2018 Apr584833 510.1111/trf.1454329633314Search in Google Scholar

[35]Gupta S, Panchal P, Gilotra K, Wilfred AM, Hou W, Siegal D, et al. Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis. Interact Cardiovasc Thorac Surg. 2020;31(2):141–51. Gupta S Panchal P Gilotra K Wilfred AM Hou W Siegal D et al Intravenous iron therapy for patients with preoperative iron deficiency or anaemia undergoing cardiac surgery reduces blood transfusions: a systematic review and meta-analysis Interact Cardiovasc Thorac Surg 2020312141 5110.1093/icvts/ivaa09432642775Search in Google Scholar

[36]COVID-19 continues to disrupt essential health services in 90% of countries [Internet]. Available from: https://www.who.int/news/item/23-04-2021-covid-19-continues-to-disrupt-essential-health-services-in-90-of-countries COVID-19 continues to disrupt essential health services in 90% of countries [Internet] Available from: https://www.who.int/news/item/23-04-2021-covid-19-continues-to-disrupt-essential-health-services-in-90-of-countriesSearch in Google Scholar

[37]Meco M, Montisci A, Giustiniano E, Greco M, Pappalardo F, Mammana L, et al. Viscoelastic Blood Tests Use in Adult Cardiac Surgery: Meta-Analysis, Meta-Regression, and Trial Sequential Analysis. J Cardiothorac Vasc Anesth. 2020;34(1):119–27. Meco M Montisci A Giustiniano E Greco M Pappalardo F Mammana L et al Viscoelastic Blood Tests Use in Adult Cardiac Surgery: Meta-Analysis, Meta-Regression, and Trial Sequential Analysis J Cardiothorac Vasc Anesth 2020341119 2710.1053/j.jvca.2019.06.03031445833Search in Google Scholar

[38]Calcaterra D, Ricci M, Shander A. “Permissive anemia.” J Card Surg. 2019;34(11):1147–9. Calcaterra D Ricci M Shander A “Permissive anemia ” J Card Surg 201934111147 910.1111/jocs.1422131441554Search in Google Scholar

[39]Shander A, Kim T-Y, Goodnough LT. Thresholds, triggers or requirements—time to look beyond the transfusion trials. J Thorac Dis. 2018;10(3):1152–7. Shander A Kim T-Y Goodnough LT Thresholds, triggers or requirements—time to look beyond the transfusion trials J Thorac Dis 20181031152 710.21037/jtd.2018.02.15590628529708142Search in Google Scholar

[40]Zeroual N, Blin C, Saour M, David H, Aouinti S, Picot M-C, et al. Restrictive Transfusion Strategy after Cardiac Surgery: Role of Central Venous Oxygen Saturation Trigger: A Randomized Controlled Trial. Anesthesiology. 2021;134(3):370–80. Zeroual N Blin C Saour M David H Aouinti S Picot M-C et al Restrictive Transfusion Strategy after Cardiac Surgery: Role of Central Venous Oxygen Saturation Trigger: A Randomized Controlled Trial Anesthesiology 20211343370 8010.1097/ALN.000000000000368233475735Search in Google Scholar