<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Intraoperative fluid management is a crucial aspect of cancer surgery, including colorectal surgery and pancreatoduodenectomy. The study tests if intraoperative multimodal monitoring reduces postoperative morbidity and duration of hospitalisation in patients undergoing major abdominal surgery treated by the same anaesthetic protocols with epidural analgesia.</p></sec>
<sec><h3>Patients and methods</h3><p>A prospective study was conducted in 2 parallel groups. High-risk surgical patients undergoing major abdominal surgery were randomly selected in the control group (CG), where standard monitoring was applied (44 patients), and the protocol group (PG), where cerebral oxygenation and extended hemodynamic monitoring were used with the protocol for intraoperative interventions (44 patients).</p></sec>
<sec><h3>Results</h3><p>There were no differences in the median length of hospital stay, CG 9 days (interquartile range [IQR] 8 days), PG 9 (5.5), p = 0.851. There was no difference in postoperative renal of cardiac impairment. Procalcitonin was significantly higher (highest postoperative value in the first 3 days) in CG, 0.75 mcg/L (IQR 3.19 mcg/L), than in PG, 0.3 mcg/L (0.88 mcg/L), p = 0.001. PG patients received a larger volume of intraoperative fluid; median intraoperative fluid balance +1300 ml (IQR 1063 ml) than CG; +375 ml (IQR 438 ml), p &lt; 0.001.</p></sec>
<sec><h3>Conclusions</h3><p>There were significant differences in intraoperative fluid management and vasopressor use. The median postoperative value of procalcitonin was significantly higher in CG, suggesting differences in immune response to tissue trauma in different intraoperative fluid status, but there was no difference in postoperative morbidity or hospital stay.</p></sec>
</abstract>

BackgroundIntraoperative fluid management is a crucial aspect of cancer surgery, including colorectal surgery and pancreatoduodenectomy. The study tests if intraoperative multimodal monitoring reduces postoperative morbidity and duration of hospitalisation in patients undergoing major abdominal surgery treated by the same anaesthetic protocols with epidural analgesia.
Patients and methodsA prospective study was conducted in 2 parallel groups. High-risk surgical patients undergoing major abdominal surgery were randomly selected in the control group (CG), where standard monitoring was applied (44 patients), and the protocol group (PG), where cerebral oxygenation and extended hemodynamic monitoring were used with the protocol for intraoperative interventions (44 patients).
ResultsThere were no differences in the median length of hospital stay, CG 9 days (interquartile range [IQR] 8 days), PG 9 (5.5), p = 0.851. There was no difference in postoperative renal of cardiac impairment. Procalcitonin was significantly higher (highest postoperative value in the first 3 days) in CG, 0.75 mcg/L (IQR 3.19 mcg/L), than in PG, 0.3 mcg/L (0.88 mcg/L), p = 0.001. PG patients received a larger volume of intraoperative fluid; median intraoperative fluid balance +1300 ml (IQR 1063 ml) than CG; +375 ml (IQR 438 ml), p < 0.001.
ConclusionsThere were significant differences in intraoperative fluid management and vasopressor use. The median postoperative value of procalcitonin was significantly higher in CG, suggesting differences in immune response to tissue trauma in different intraoperative fluid status, but there was no difference in postoperative morbidity or hospital stay.

Influence of different intraoperative fluid management on postoperative outcome after abdominal tumours resection

Department of Anesthesiology and Surgical Intensive Care

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

BackgroundIntraoperative fluid management is a crucial aspect of cancer surgery, including colorectal surgery and pancreatoduodenectomy. The study tests if...

Influence of different intraoperative fluid management on postoperative outcome after abdominal tumours resection

Article Category: Research Article

Published Online: Mar 07, 2024

Page range: 279 - 288

Received: Aug 31, 2023

Accepted: Dec 10, 2023

DOI: https://doi.org/10.2478/raon-2024-0015

Keywords
postoperative complications, intraoperative monitoring, multimodal monitoring, hemodynamic monitoring, cerebral tissue oxygenation, abdominal surgery

© 2024 Matej Jenko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Influence of different intraoperative fluid management on postoperative outcome after abdominal tumours resection

Article Category: Research Article

Published Online: Mar 07, 2024

Page range: 279 - 288

Received: Aug 31, 2023

Accepted: Dec 10, 2023

DOI: https://doi.org/10.2478/raon-2024-0015

Keywordspostoperative complications, intraoperative monitoring, multimodal monitoring, hemodynamic monitoring, cerebral tissue oxygenation, abdominal surgery

© 2024 Matej Jenko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
postoperative complications, intraoperative monitoring, multimodal monitoring, hemodynamic monitoring, cerebral tissue oxygenation, abdominal surgery