<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3′MBR and 5′mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma.</p>
</sec>
<sec><h3>Patients and methods</h3>
<p>We included patients diagnosed with follicular lymphoma who received at least 1 cycle of systemic treatment and had the t(14;18)(q32;q21) translocation detected by polymerase chain reaction (PCR) at MBR, mcr or 3′MBR prior to first treatment. Among patients with different breakpoints, sex, age, disease grade, stage, B-symptoms, follicular lymphoma international prognostic index (FLIPI), presence of bulky disease, progression free survival and overall survival were compared.</p>
</sec>
<sec><h3>Results</h3>
<p>Of 84 patients, 63 had breakpoint at MBR, 17 at mcr and 4 at 3′MBR. At diagnosis, the MBR group had a significantly lower disease stage than the mcr group. Although not significant, in the MBR group we found a higher progression-free survival (PFS) and overall survival (OS), lower grade, age, FLIPI, and less B-symptoms.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Compared to patients with mcr breakpoint, those with MBR breakpoint seem to be characterised by more favourable clinical characteristics. However, a larger study would be required to support our observation.</p>
</sec>
</abstract>

Background
t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3′MBR and 5′mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma.

Patients and methods
We included patients diagnosed with follicular lymphoma who received at least 1 cycle of systemic treatment and had the t(14;18)(q32;q21) translocation detected by polymerase chain reaction (PCR) at MBR, mcr or 3′MBR prior to first treatment. Among patients with different breakpoints, sex, age, disease grade, stage, B-symptoms, follicular lymphoma international prognostic index (FLIPI), presence of bulky disease, progression free survival and overall survival were compared.

Results
Of 84 patients, 63 had breakpoint at MBR, 17 at mcr and 4 at 3′MBR. At diagnosis, the MBR group had a significantly lower disease stage than the mcr group. Although not significant, in the MBR group we found a higher progression-free survival (PFS) and overall survival (OS), lower grade, age, FLIPI, and less B-symptoms.

Conclusions
Compared to patients with mcr breakpoint, those with MBR breakpoint seem to be characterised by more favourable clinical characteristics. However, a larger study would be required to support our observation.

Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma

Radiology and Oncology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein...

Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma

Article Category: Research Article

Published Online: Jul 13, 2023

Page range: 487 - 492

Received: Apr 04, 2023

Accepted: May 31, 2023

DOI: https://doi.org/10.2478/raon-2023-0030

Keywords
follicular lymphoma, t(14;18) translocation, breakpoint region, clinical characteristics

© 2023 Matej Panjan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma

Article Category: Research Article

Published Online: Jul 13, 2023

Page range: 487 - 492

Received: Apr 04, 2023

Accepted: May 31, 2023

DOI: https://doi.org/10.2478/raon-2023-0030

Keywordsfollicular lymphoma, t(14;18) translocation, breakpoint region, clinical characteristics

© 2023 Matej Panjan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
follicular lymphoma, t(14;18) translocation, breakpoint region, clinical characteristics