Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy
, , , , , , , and | Jun 21, 2023
About this article
Article Category: Research Article
Published Online: Jun 21, 2023
Page range: 220 - 228
Received: Feb 13, 2023
Accepted: May 18, 2023
DOI: https://doi.org/10.2478/raon-2023-0027
Keywords
© 2023 Domen Ribnikar et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
FIGURE 1.
FIGURE 2.
FIGURE 3.
Simple Cox proportional hazards model for DMFS in the PIK3CA mutated patient cohort
| 0.99 | 0.96–1.02 | 1.0 | |
| 0.92 | 0.75–1.14 | 1.0 | |
| 1.07 | 0.90–1.28 | 1.0 |
Distribution of systemic therapy in all patients and according to PIK3CA mutation status
| 12 (3) | 5 (3) | 7 (3) | |
| 249 (68) | 115 (70) | 134 (67) | |
| 13 (4) | 5 (3) | 8 (4) | |
| 91 (25) | 39 (24) | 52 (26) | |
| 25 (7) | 10 (6) | 15 (7) | |
| 106 (29) | 45 (27) | 61 (30) | |
| 127 (35) | 54 (33) | 73 (37) | |
| 107 (29) | 55 (34) | 52 (26) | |
| 5 (0.2–16.7) | 5 (0.4–16.7) | 5 (0.2–11.2) |
Advanced Cox proportional hazards model for OS in the PIK3CA mutated patient cohort
| 1.05 | 1.02–1.08 | 0.014 | |
| 1.38 | 0.90–2.10 | 0.84 | |
| |
Ref | ||
| |
1.41 | 0.59–3.38 | 1.0 |
| |
5.52 | 1.67–18.18 | 0.04 |
| 0.94 | 0.72–1.22 | 1.0 | |
| 1 | 0.99–1.01 | 1.0 | |
| |
Ref | ||
| |
1.32 | 0.79–2.21 | 1.0 |
| 1.58 | 1.32–1.88 | < 0.001 | |
| 0.68 | 0.55–0.86 | 0.01 | |
| 0.73 | 0.60–0.88 | 0.01 | |
Characteristics of the included patients and their tumors
| 62.8 (33–90) | 63.1 | 62.4 | |
| 21 | 19 | 21 | |
| |
209 (57) | 100 (61) | 109 (54) |
| |
84 (23) | 37 (22) | 47 (23) |
| |
26 (7) | 1 (7) | 15 (8) |
| |
46 (13) | 16 (10) | 30 (15) |
| |
52 (14) | 20 (12) | 32 (16) |
| |
270 (74) | 134 (82) | 136 (68) |
| |
43 (12) | 10 (6) | 33 (16) |
| |
299 (82) | 136 (46) | 159 (54) |
| |
39 (11) | 14 (36) | 25 (64) |
| |
20 (6) | 9 (45) | 11 (55) |
| |
7 (2) | 2 (29) | 5 (71) |
| 3 (1–50) | 2.5 (1–50) | 3 (1 |
|
| |
284 (78) | 138 (84) | 146 (73) |
| |
55 (15) | 19 (12) | 36 (18) |
| |
26 (7) | 7 (4) | 19 (9) |
| 24 (7) | 4 (2) | 20 (10) | |
| 3 (1 |
3 | 3 | |
| 10.8 (0.1 |
10.8 | 10.7 | |
Advanced Cox proportional hazards model for DMFS in the PIK3CA mutated patient cohort
| 1.01 | 0.97–1.05 | 1.0 | |
| 0.99 | 0.57–1.71 | 1.0 | |
| |
Ref | ||
| |
0.91 | 0.26–3.22 | 1.0 |
| |
1.03 | 0.16–6.83 | 1.0 |
| 1.35 | 0.93–1.95 | 1.0 | |
| 1 | 0.99–1.02 | 1.0 | |
| |
Ref | ||
| |
2.19 | 1.01–4.80 | 0.582 |
| 1.64 | 1.30–2.06 | < 0.001 | |
| 1.02 | 0.81–1.29 | 1.0 | |
| 1.06 | 0.87–1.28 | 1.0 | |
Simple Cox proportional hazards model for OS in the PIK3CA mutated patient cohort
| 1.05 | 1.02–1.07 | < 0.001 | |
| 0.73 | 0.61–0.88 | 0.002 | |
| 0.79 | 0.67–0.93 | 0.005 |