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ADC values as a biomarker of fetal brain maturation

Lucija Kobal

Lucija Kobal

Faculty of Medicine, University of LjubljanaLjubljana, Slovenia
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Kobal, Lucija
, 
Katarina Surlan Popovic

Katarina Surlan Popovic

Clinical Institute of Radiology, University Medical Centre LjubljanaLjubljana, Slovenia
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Surlan Popovic, Katarina
, 
Jernej Avsenik

Jernej Avsenik

Clinical Institute of Radiology, University Medical Centre LjubljanaLjubljana, Slovenia
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Avsenik, Jernej
 and 
Tina Vipotnik Vesnaver

Tina Vipotnik Vesnaver

Clinical Institute of Radiology, University Medical Centre LjubljanaLjubljana, Slovenia
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Vipotnik Vesnaver, Tina
  
Jun 21, 2023
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Article Category: Research Article
Published Online: Jun 21, 2023
Page range: 178 - 183
Received: Feb 03, 2023
Accepted: Apr 17, 2023
DOI: https://doi.org/10.2478/raon-2023-0022
Keywords
© 2023 Lucija Kobal et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

FIGURE 1.

Position of the ROI in the brain of a fetus with a gestational age of 29 weeks. Region of interests (ROIs) were placed in each brain region bilaterally. Markings are visible only on one side. (A) Frontal white matter, (B) parietal white matter, (C) temporal white matter, (D) occipital white matter, (E) thalamus, (F) pons, (G) hemisphere of the cerebellum.
Position of the ROI in the brain of a fetus with a gestational age of 29 weeks. Region of interests (ROIs) were placed in each brain region bilaterally. Markings are visible only on one side. (A) Frontal white matter, (B) parietal white matter, (C) temporal white matter, (D) occipital white matter, (E) thalamus, (F) pons, (G) hemisphere of the cerebellum.

FIGURE 2.

Average apparent diffusion coefficient (ADC) values for different regions of interest (ROIs).
Average apparent diffusion coefficient (ADC) values for different regions of interest (ROIs).

FIGURE 3.

Association between apparent diffusion coefficient (ADC) values in different brain regions and fetal gestational age in days. (A) Frontal white matter, (B) parietal white matter, (C) temporal white matter, (D) occipital white matter, (E) thalamus, (F) pons, (G) cerebellum.
Association between apparent diffusion coefficient (ADC) values in different brain regions and fetal gestational age in days. (A) Frontal white matter, (B) parietal white matter, (C) temporal white matter, (D) occipital white matter, (E) thalamus, (F) pons, (G) cerebellum.

Intraclass correlation coefficient (ICC) for different regions of interest (ROIs)

ROI ICC
FWM 0.91
PWM 0.90
TWM 0.75
OWM 0.78
Thalami 0.85
Pons 0.81
Cerebellum 0.92
Language:
English
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Journal Subjects:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
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